Laser-assisted surface texturing of Ti/Zr multilayers for mesenchymal stem cell response
Аутори
Petrović, SuzanaPeruško, Davor
Skoulas, Evangelos
Kovač, Janez
Mitrić, Miodrag
Potočnik, Jelena
Rakočević, Zlatko Lj.
Stratakis, Emmanuel
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The formation of an ordered surface texture with micro and nanometer features on Ti/Zr multilayers is studied for better understanding and improvement of cell integration. Nanocomposite in form 30×(Ti/Zr)/Si thin films was deposited by ion sputtering on Si substrate for biocompatibility investigation. Surface texturing by femtosecond laser processing made it possible to form the laser-induced periodic surface structure (LIPSS) in each laser-written line. At fluence slightly above the ablation threshold, beside the formation of low spatial frequency-LIPSS (LSFL) oriented perpendicular to the direction of the laser polarization, the laser-induced surface oxidation was achieved on the irradiated area. Intermixing between the Ti and Zr layers with the formation of alloy in the sub-surface region was attained during the laser processing. The surface of the Ti/Zr multilayer system with changed composition and topography was used to observe the effect of topography on the survival, adhesion a...nd proliferation of the murine mesenchymal stem cells (MSCs). Confocal and SEM microscopy images showed that cell adhesion and their growth improve on these modified surfaces, with tendency of the cell orientation along of LIPSS in laser-written lines. © 2019 by the authors.
Кључне речи:
multilayer thin films / Ti-based alloy / ultrafast laser-modification / cell responseИзвор:
Coatings, 2019, 9, 12, 854-Финансирање / пројекти:
- NFFA-Europe - Nanoscience Foundries and Fine Analysis - Europe (EU-H2020-654360)
- Физички процеси у синтези нових наноструктурних материјала (RS-MESTD-Basic Research (BR or ON)-171023)
- Генерисање и карактеризација нанофотонских функционалних структура у биомедицини и информатици (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45016)
- Функционални, функционализовани и усавршени нано материјали (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45005)
DOI: 10.3390/coatings9120854
ISSN: 2079-6412
WoS: 000506682800082
Scopus: 2-s2.0-85078039734
Колекције
Институција/група
VinčaTY - JOUR AU - Petrović, Suzana AU - Peruško, Davor AU - Skoulas, Evangelos AU - Kovač, Janez AU - Mitrić, Miodrag AU - Potočnik, Jelena AU - Rakočević, Zlatko Lj. AU - Stratakis, Emmanuel PY - 2019 UR - https://vinar.vin.bg.ac.rs/handle/123456789/8816 AB - The formation of an ordered surface texture with micro and nanometer features on Ti/Zr multilayers is studied for better understanding and improvement of cell integration. Nanocomposite in form 30×(Ti/Zr)/Si thin films was deposited by ion sputtering on Si substrate for biocompatibility investigation. Surface texturing by femtosecond laser processing made it possible to form the laser-induced periodic surface structure (LIPSS) in each laser-written line. At fluence slightly above the ablation threshold, beside the formation of low spatial frequency-LIPSS (LSFL) oriented perpendicular to the direction of the laser polarization, the laser-induced surface oxidation was achieved on the irradiated area. Intermixing between the Ti and Zr layers with the formation of alloy in the sub-surface region was attained during the laser processing. The surface of the Ti/Zr multilayer system with changed composition and topography was used to observe the effect of topography on the survival, adhesion and proliferation of the murine mesenchymal stem cells (MSCs). Confocal and SEM microscopy images showed that cell adhesion and their growth improve on these modified surfaces, with tendency of the cell orientation along of LIPSS in laser-written lines. © 2019 by the authors. T2 - Coatings T1 - Laser-assisted surface texturing of Ti/Zr multilayers for mesenchymal stem cell response VL - 9 IS - 12 SP - 854 DO - 10.3390/coatings9120854 ER -
@article{ author = "Petrović, Suzana and Peruško, Davor and Skoulas, Evangelos and Kovač, Janez and Mitrić, Miodrag and Potočnik, Jelena and Rakočević, Zlatko Lj. and Stratakis, Emmanuel", year = "2019", abstract = "The formation of an ordered surface texture with micro and nanometer features on Ti/Zr multilayers is studied for better understanding and improvement of cell integration. Nanocomposite in form 30×(Ti/Zr)/Si thin films was deposited by ion sputtering on Si substrate for biocompatibility investigation. Surface texturing by femtosecond laser processing made it possible to form the laser-induced periodic surface structure (LIPSS) in each laser-written line. At fluence slightly above the ablation threshold, beside the formation of low spatial frequency-LIPSS (LSFL) oriented perpendicular to the direction of the laser polarization, the laser-induced surface oxidation was achieved on the irradiated area. Intermixing between the Ti and Zr layers with the formation of alloy in the sub-surface region was attained during the laser processing. The surface of the Ti/Zr multilayer system with changed composition and topography was used to observe the effect of topography on the survival, adhesion and proliferation of the murine mesenchymal stem cells (MSCs). Confocal and SEM microscopy images showed that cell adhesion and their growth improve on these modified surfaces, with tendency of the cell orientation along of LIPSS in laser-written lines. © 2019 by the authors.", journal = "Coatings", title = "Laser-assisted surface texturing of Ti/Zr multilayers for mesenchymal stem cell response", volume = "9", number = "12", pages = "854", doi = "10.3390/coatings9120854" }
Petrović, S., Peruško, D., Skoulas, E., Kovač, J., Mitrić, M., Potočnik, J., Rakočević, Z. Lj.,& Stratakis, E.. (2019). Laser-assisted surface texturing of Ti/Zr multilayers for mesenchymal stem cell response. in Coatings, 9(12), 854. https://doi.org/10.3390/coatings9120854
Petrović S, Peruško D, Skoulas E, Kovač J, Mitrić M, Potočnik J, Rakočević ZL, Stratakis E. Laser-assisted surface texturing of Ti/Zr multilayers for mesenchymal stem cell response. in Coatings. 2019;9(12):854. doi:10.3390/coatings9120854 .
Petrović, Suzana, Peruško, Davor, Skoulas, Evangelos, Kovač, Janez, Mitrić, Miodrag, Potočnik, Jelena, Rakočević, Zlatko Lj., Stratakis, Emmanuel, "Laser-assisted surface texturing of Ti/Zr multilayers for mesenchymal stem cell response" in Coatings, 9, no. 12 (2019):854, https://doi.org/10.3390/coatings9120854 . .