Graphene quantum dots as singlet oxygen producer or radical quencher - The matter of functionalization with urea/thiourea
Samo za registrovane korisnike
2020
Autori
Jovanović, Svetlana P.Syrgiannis, Zois
Budimir, Milica
Milivojević, Dušan
Jovanović, Dragana J.
Pavlović, Vladimir B.
Papan, Jelena
Bartenwerfer, Malte
Mojsin, Marija
Stevanović, Milena J.
Todorović-Marković, Biljana
Članak u časopisu (Objavljena verzija)
,
© 2019
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Due to their low cost and possible green synthesis, high stability and resistance to photobleaching, graphene quantum dots (GQDs) can be considered as one of the class of carbon nanomaterials which may have great potential as an agent for photosensitized oxygen activation. In such a way, GQDs can be used as a theranostic agent in photodynamic therapy. In this work pristine GQDs, GQDs irradiated with gamma rays and GQDs doped with N and N, S atoms are produced using a simple, green approach. By using different techniques (AFM, HR-TEM, SEM-EDS, FTIR, XRD, PL and UV–Vis) we investigated structural and optical properties of the new types of GQDs. We showed that GQDs functionalized with thiourea (GQDs-TU) completely lost the ability to produce singlet oxygen (1O2) upon photoexcitation while functionalization with urea (GQDs-U) improves the capability of GQDs to produce 1O2 upon the same conditions. Thus, presented GQDs modification with urea seems like a promising approach for the productio...n of the efficient photosensitizer. On the opposite, GQDs-TU are efficient [rad]OH quencher. Due to high singlet oxygen production and low cytotoxicity below 100 μg/mL against HeLa cells, GQDs-U is a good candidate as an agent in photodynamic therapy at this concentration. © 2019
Ključne reči:
Graphene quantum dots / Photodynamic therapy / Singlet oxygen / Cytotoxicity / AntioxidantIzvor:
Materials Science and Engineering: C, 2020, 109, 110539-Finansiranje / projekti:
- Tanki slojevi jednoslojnih ugljeničnih nanotuba i grafena za primenu u elektronici (RS-172003)
- Proučavanje signalnih puteva i epigenetičkih mehanizama uključenih u kontrolu ekspresije humanih SOX gena: dalje rasvetljavanje njihove uloge u određivanju sudbine i diferencijaciji ćelija (RS-173051)
- Bilateral collaboration between the Republic of Serbia and Germany [451-03-01732/2017-09/7]
DOI: 10.1016/j.msec.2019.110539
ISSN: 0928-4931
PubMed: 32229000
WoS: 000527394600048
Scopus: 2-s2.0-85076495597
Institucija/grupa
VinčaTY - JOUR AU - Jovanović, Svetlana P. AU - Syrgiannis, Zois AU - Budimir, Milica AU - Milivojević, Dušan AU - Jovanović, Dragana J. AU - Pavlović, Vladimir B. AU - Papan, Jelena AU - Bartenwerfer, Malte AU - Mojsin, Marija AU - Stevanović, Milena J. AU - Todorović-Marković, Biljana PY - 2020 UR - https://vinar.vin.bg.ac.rs/handle/123456789/8672 AB - Due to their low cost and possible green synthesis, high stability and resistance to photobleaching, graphene quantum dots (GQDs) can be considered as one of the class of carbon nanomaterials which may have great potential as an agent for photosensitized oxygen activation. In such a way, GQDs can be used as a theranostic agent in photodynamic therapy. In this work pristine GQDs, GQDs irradiated with gamma rays and GQDs doped with N and N, S atoms are produced using a simple, green approach. By using different techniques (AFM, HR-TEM, SEM-EDS, FTIR, XRD, PL and UV–Vis) we investigated structural and optical properties of the new types of GQDs. We showed that GQDs functionalized with thiourea (GQDs-TU) completely lost the ability to produce singlet oxygen (1O2) upon photoexcitation while functionalization with urea (GQDs-U) improves the capability of GQDs to produce 1O2 upon the same conditions. Thus, presented GQDs modification with urea seems like a promising approach for the production of the efficient photosensitizer. On the opposite, GQDs-TU are efficient [rad]OH quencher. Due to high singlet oxygen production and low cytotoxicity below 100 μg/mL against HeLa cells, GQDs-U is a good candidate as an agent in photodynamic therapy at this concentration. © 2019 T2 - Materials Science and Engineering: C T1 - Graphene quantum dots as singlet oxygen producer or radical quencher - The matter of functionalization with urea/thiourea VL - 109 SP - 110539 DO - 10.1016/j.msec.2019.110539 ER -
@article{ author = "Jovanović, Svetlana P. and Syrgiannis, Zois and Budimir, Milica and Milivojević, Dušan and Jovanović, Dragana J. and Pavlović, Vladimir B. and Papan, Jelena and Bartenwerfer, Malte and Mojsin, Marija and Stevanović, Milena J. and Todorović-Marković, Biljana", year = "2020", abstract = "Due to their low cost and possible green synthesis, high stability and resistance to photobleaching, graphene quantum dots (GQDs) can be considered as one of the class of carbon nanomaterials which may have great potential as an agent for photosensitized oxygen activation. In such a way, GQDs can be used as a theranostic agent in photodynamic therapy. In this work pristine GQDs, GQDs irradiated with gamma rays and GQDs doped with N and N, S atoms are produced using a simple, green approach. By using different techniques (AFM, HR-TEM, SEM-EDS, FTIR, XRD, PL and UV–Vis) we investigated structural and optical properties of the new types of GQDs. We showed that GQDs functionalized with thiourea (GQDs-TU) completely lost the ability to produce singlet oxygen (1O2) upon photoexcitation while functionalization with urea (GQDs-U) improves the capability of GQDs to produce 1O2 upon the same conditions. Thus, presented GQDs modification with urea seems like a promising approach for the production of the efficient photosensitizer. On the opposite, GQDs-TU are efficient [rad]OH quencher. Due to high singlet oxygen production and low cytotoxicity below 100 μg/mL against HeLa cells, GQDs-U is a good candidate as an agent in photodynamic therapy at this concentration. © 2019", journal = "Materials Science and Engineering: C", title = "Graphene quantum dots as singlet oxygen producer or radical quencher - The matter of functionalization with urea/thiourea", volume = "109", pages = "110539", doi = "10.1016/j.msec.2019.110539" }
Jovanović, S. P., Syrgiannis, Z., Budimir, M., Milivojević, D., Jovanović, D. J., Pavlović, V. B., Papan, J., Bartenwerfer, M., Mojsin, M., Stevanović, M. J.,& Todorović-Marković, B.. (2020). Graphene quantum dots as singlet oxygen producer or radical quencher - The matter of functionalization with urea/thiourea. in Materials Science and Engineering: C, 109, 110539. https://doi.org/10.1016/j.msec.2019.110539
Jovanović SP, Syrgiannis Z, Budimir M, Milivojević D, Jovanović DJ, Pavlović VB, Papan J, Bartenwerfer M, Mojsin M, Stevanović MJ, Todorović-Marković B. Graphene quantum dots as singlet oxygen producer or radical quencher - The matter of functionalization with urea/thiourea. in Materials Science and Engineering: C. 2020;109:110539. doi:10.1016/j.msec.2019.110539 .
Jovanović, Svetlana P., Syrgiannis, Zois, Budimir, Milica, Milivojević, Dušan, Jovanović, Dragana J., Pavlović, Vladimir B., Papan, Jelena, Bartenwerfer, Malte, Mojsin, Marija, Stevanović, Milena J., Todorović-Marković, Biljana, "Graphene quantum dots as singlet oxygen producer or radical quencher - The matter of functionalization with urea/thiourea" in Materials Science and Engineering: C, 109 (2020):110539, https://doi.org/10.1016/j.msec.2019.110539 . .