Performances of ionic liquid matrices with butyl ammonium counterion for matrix-assisted laser desorption/ionization mass spectrometric detection and analysis of sucralfate
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Petković, MarijanaLeopold, Jenny
Popović, Iva A.
Dimić, Dušan
Ilić, Jelica
Nenadović, Miloš
Rakočević, Zlatko Lj.
Schiller, Jürgen
Article (Published version)
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© 2019 Taylor & Francis Group, LLC.
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In this work, the performances of two ionic liquid matrices (ILMs) with the same ammonium counterpart for mass spectrometric analysis of the insoluble and soluble sucralfate were compared. Matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS) was performed assisted by the butylammonium salts of α-cyano-hydroxycinnamic acid (CHCAB) and 2,5-dihydroxybenzoic acid (DHBB). CHCAB has a higher IE than DHBB, but better optical properties. CHCAB is more suitable for the analysis of sucralfate, although molecular ions of both compounds were detectable only with low intensities. Thus, optical properties of ILMs are crucial to enhance the sensitivity of MALDI MS detection of polysulfated oligosaccharides. © 2019, © 2019 Taylor & Francis Group, LLC.
Keywords:
2,5-dihydroxybenzoic acid / Ionic liquid matrices / matrix-assisted laser desorption/ionization time-of-flight mass spectrometry / sucralfate / α-cyano-hydroxycinnamic acidSource:
Journal of Carbohydrate Chemistry, 2020, 39, 1, 1-23Funding / projects:
- Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) [59307082] [TRR67] [Projects A8 and Z3]
- Mechanistic studies of the reactions of transition metal ion complexes with biologically relevant molecules (RS-MESTD-Basic Research (BR or ON)-172011)
- Functional, Functionalized and Advanced Nanomaterials (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45005)
- The structure and dynamics of molecular systems in ground and excited electronic states (RS-MESTD-Basic Research (BR or ON)-172040)
- Grant CQM_2018_005_STMG_MS at CQM Madeira, Portugal [M1420-01-0145-FEDER-000005]
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VinčaTY - JOUR AU - Petković, Marijana AU - Leopold, Jenny AU - Popović, Iva A. AU - Dimić, Dušan AU - Ilić, Jelica AU - Nenadović, Miloš AU - Rakočević, Zlatko Lj. AU - Schiller, Jürgen PY - 2020 UR - https://vinar.vin.bg.ac.rs/handle/123456789/8623 AB - In this work, the performances of two ionic liquid matrices (ILMs) with the same ammonium counterpart for mass spectrometric analysis of the insoluble and soluble sucralfate were compared. Matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS) was performed assisted by the butylammonium salts of α-cyano-hydroxycinnamic acid (CHCAB) and 2,5-dihydroxybenzoic acid (DHBB). CHCAB has a higher IE than DHBB, but better optical properties. CHCAB is more suitable for the analysis of sucralfate, although molecular ions of both compounds were detectable only with low intensities. Thus, optical properties of ILMs are crucial to enhance the sensitivity of MALDI MS detection of polysulfated oligosaccharides. © 2019, © 2019 Taylor & Francis Group, LLC. T2 - Journal of Carbohydrate Chemistry T1 - Performances of ionic liquid matrices with butyl ammonium counterion for matrix-assisted laser desorption/ionization mass spectrometric detection and analysis of sucralfate VL - 39 IS - 1 SP - 1 EP - 23 DO - 10.1080/07328303.2019.1669633 ER -
@article{ author = "Petković, Marijana and Leopold, Jenny and Popović, Iva A. and Dimić, Dušan and Ilić, Jelica and Nenadović, Miloš and Rakočević, Zlatko Lj. and Schiller, Jürgen", year = "2020", abstract = "In this work, the performances of two ionic liquid matrices (ILMs) with the same ammonium counterpart for mass spectrometric analysis of the insoluble and soluble sucralfate were compared. Matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS) was performed assisted by the butylammonium salts of α-cyano-hydroxycinnamic acid (CHCAB) and 2,5-dihydroxybenzoic acid (DHBB). CHCAB has a higher IE than DHBB, but better optical properties. CHCAB is more suitable for the analysis of sucralfate, although molecular ions of both compounds were detectable only with low intensities. Thus, optical properties of ILMs are crucial to enhance the sensitivity of MALDI MS detection of polysulfated oligosaccharides. © 2019, © 2019 Taylor & Francis Group, LLC.", journal = "Journal of Carbohydrate Chemistry", title = "Performances of ionic liquid matrices with butyl ammonium counterion for matrix-assisted laser desorption/ionization mass spectrometric detection and analysis of sucralfate", volume = "39", number = "1", pages = "1-23", doi = "10.1080/07328303.2019.1669633" }
Petković, M., Leopold, J., Popović, I. A., Dimić, D., Ilić, J., Nenadović, M., Rakočević, Z. Lj.,& Schiller, J.. (2020). Performances of ionic liquid matrices with butyl ammonium counterion for matrix-assisted laser desorption/ionization mass spectrometric detection and analysis of sucralfate. in Journal of Carbohydrate Chemistry, 39(1), 1-23. https://doi.org/10.1080/07328303.2019.1669633
Petković M, Leopold J, Popović IA, Dimić D, Ilić J, Nenadović M, Rakočević ZL, Schiller J. Performances of ionic liquid matrices with butyl ammonium counterion for matrix-assisted laser desorption/ionization mass spectrometric detection and analysis of sucralfate. in Journal of Carbohydrate Chemistry. 2020;39(1):1-23. doi:10.1080/07328303.2019.1669633 .
Petković, Marijana, Leopold, Jenny, Popović, Iva A., Dimić, Dušan, Ilić, Jelica, Nenadović, Miloš, Rakočević, Zlatko Lj., Schiller, Jürgen, "Performances of ionic liquid matrices with butyl ammonium counterion for matrix-assisted laser desorption/ionization mass spectrometric detection and analysis of sucralfate" in Journal of Carbohydrate Chemistry, 39, no. 1 (2020):1-23, https://doi.org/10.1080/07328303.2019.1669633 . .