Antioxidant enzymes expression in lymphocytes of patients undergoing carotid endarterectomy
Autori
Obradović, Milan M.Zafirović, Sonja
Essack, Magbubah
Dimitrov, Jelena
Živković, Lada
Spremo-Potparević, Biljana
Radak, Đorđe J.
Bajić, Vladimir B.
Isenović, Esma R.
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
To remedy carotid artery stenosis and prevent stroke surgical intervention is commonly used, and the gold standard being carotid endarterectomy (CEA). During CEA cerebrovascular hemoglobin oxygen saturation decreases and when this decrease reaches critical levels it leads to cerebral hypoxia that causes neuronal damage. One of the proposed mechanism that affects changes during CEA and contribute to acute brain ischemia (ABI) is oxidative stress. The increased production of reactive oxygen species and reactive nitrogen species during ABI may cause an unregulated inflammatory response and further lead to structural and functional injury of neurons. Antioxidant activity are involved in the protection against neuronal damage after cerebral ischemia. We hypothesized that neuronal injury and poor outcomes in patients undergoing CEA may be results of oxidative stress that disturbed function of antioxidant enzymes and contributed to the DNA damage in lymphocytes. © 2019 The Authors
Ključne reči:
Superoxide dismutase / Catalase / DNA damage / Acute brain ischemia / Cerebrovascular hemoglobin oxygen saturationIzvor:
Medical Hypotheses, 2020, 134, 109419-Izdavač:
- Churchill Livingstone
Finansiranje / projekti:
- Hormonska regulacija ekspresije i aktivnosti azot oksid sintaze i natrijum-kalijumove pumpe u eksperimentalnim modelima insulinske rezistencije, dijabetesa i kardiovaskularnih poremećaja (RS-MESTD-Basic Research (BR or ON)-173033)
- Karotidna bolest u Srbiji - patološka dinamika, prevencija, dijagnostika i inovativni terapijski postupci (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41002)
- Aberacije ćelijskog ciklusa i uticaj oksidativnog stresa na neurodegenerativne procese i malignu transformaciju ćelije (RS-MESTD-Basic Research (BR or ON)-173034)
- COST Action [CA15132, ‘hCOMET’]
- KAUST grant [OSR#4129]
- KAUST Base Research Fund [BAS/1/1606-01-01]
- KAUST Office of Sponsored Research (OSR) [FCC/1/1976-17-01]
DOI: 10.1016/j.mehy.2019.109419
ISSN: 0306-9877
PubMed: 31622925
WoS: 000510971500004
Scopus: 2-s2.0-85073096930
Kolekcije
Institucija/grupa
VinčaTY - JOUR AU - Obradović, Milan M. AU - Zafirović, Sonja AU - Essack, Magbubah AU - Dimitrov, Jelena AU - Živković, Lada AU - Spremo-Potparević, Biljana AU - Radak, Đorđe J. AU - Bajić, Vladimir B. AU - Isenović, Esma R. PY - 2020 UR - https://vinar.vin.bg.ac.rs/handle/123456789/8487 AB - To remedy carotid artery stenosis and prevent stroke surgical intervention is commonly used, and the gold standard being carotid endarterectomy (CEA). During CEA cerebrovascular hemoglobin oxygen saturation decreases and when this decrease reaches critical levels it leads to cerebral hypoxia that causes neuronal damage. One of the proposed mechanism that affects changes during CEA and contribute to acute brain ischemia (ABI) is oxidative stress. The increased production of reactive oxygen species and reactive nitrogen species during ABI may cause an unregulated inflammatory response and further lead to structural and functional injury of neurons. Antioxidant activity are involved in the protection against neuronal damage after cerebral ischemia. We hypothesized that neuronal injury and poor outcomes in patients undergoing CEA may be results of oxidative stress that disturbed function of antioxidant enzymes and contributed to the DNA damage in lymphocytes. © 2019 The Authors PB - Churchill Livingstone T2 - Medical Hypotheses T1 - Antioxidant enzymes expression in lymphocytes of patients undergoing carotid endarterectomy VL - 134 SP - 109419 DO - 10.1016/j.mehy.2019.109419 ER -
@article{ author = "Obradović, Milan M. and Zafirović, Sonja and Essack, Magbubah and Dimitrov, Jelena and Živković, Lada and Spremo-Potparević, Biljana and Radak, Đorđe J. and Bajić, Vladimir B. and Isenović, Esma R.", year = "2020", abstract = "To remedy carotid artery stenosis and prevent stroke surgical intervention is commonly used, and the gold standard being carotid endarterectomy (CEA). During CEA cerebrovascular hemoglobin oxygen saturation decreases and when this decrease reaches critical levels it leads to cerebral hypoxia that causes neuronal damage. One of the proposed mechanism that affects changes during CEA and contribute to acute brain ischemia (ABI) is oxidative stress. The increased production of reactive oxygen species and reactive nitrogen species during ABI may cause an unregulated inflammatory response and further lead to structural and functional injury of neurons. Antioxidant activity are involved in the protection against neuronal damage after cerebral ischemia. We hypothesized that neuronal injury and poor outcomes in patients undergoing CEA may be results of oxidative stress that disturbed function of antioxidant enzymes and contributed to the DNA damage in lymphocytes. © 2019 The Authors", publisher = "Churchill Livingstone", journal = "Medical Hypotheses", title = "Antioxidant enzymes expression in lymphocytes of patients undergoing carotid endarterectomy", volume = "134", pages = "109419", doi = "10.1016/j.mehy.2019.109419" }
Obradović, M. M., Zafirović, S., Essack, M., Dimitrov, J., Živković, L., Spremo-Potparević, B., Radak, Đ. J., Bajić, V. B.,& Isenović, E. R.. (2020). Antioxidant enzymes expression in lymphocytes of patients undergoing carotid endarterectomy. in Medical Hypotheses Churchill Livingstone., 134, 109419. https://doi.org/10.1016/j.mehy.2019.109419
Obradović MM, Zafirović S, Essack M, Dimitrov J, Živković L, Spremo-Potparević B, Radak ĐJ, Bajić VB, Isenović ER. Antioxidant enzymes expression in lymphocytes of patients undergoing carotid endarterectomy. in Medical Hypotheses. 2020;134:109419. doi:10.1016/j.mehy.2019.109419 .
Obradović, Milan M., Zafirović, Sonja, Essack, Magbubah, Dimitrov, Jelena, Živković, Lada, Spremo-Potparević, Biljana, Radak, Đorđe J., Bajić, Vladimir B., Isenović, Esma R., "Antioxidant enzymes expression in lymphocytes of patients undergoing carotid endarterectomy" in Medical Hypotheses, 134 (2020):109419, https://doi.org/10.1016/j.mehy.2019.109419 . .