Antioxidant enzymes expression in lymphocytes of patients undergoing carotid endarterectomy
Authors
Obradović, Milan M.Zafirović, Sonja
Essack, Magbubah
Dimitrov, Jelena
Živković, Lada
Spremo-Potparević, Biljana
Radak, Đorđe J.
Bajić, Vladimir B.
Isenović, Esma R.
Article (Published version)
Metadata
Show full item recordAbstract
To remedy carotid artery stenosis and prevent stroke surgical intervention is commonly used, and the gold standard being carotid endarterectomy (CEA). During CEA cerebrovascular hemoglobin oxygen saturation decreases and when this decrease reaches critical levels it leads to cerebral hypoxia that causes neuronal damage. One of the proposed mechanism that affects changes during CEA and contribute to acute brain ischemia (ABI) is oxidative stress. The increased production of reactive oxygen species and reactive nitrogen species during ABI may cause an unregulated inflammatory response and further lead to structural and functional injury of neurons. Antioxidant activity are involved in the protection against neuronal damage after cerebral ischemia. We hypothesized that neuronal injury and poor outcomes in patients undergoing CEA may be results of oxidative stress that disturbed function of antioxidant enzymes and contributed to the DNA damage in lymphocytes. © 2019 The Authors
Keywords:
Superoxide dismutase / Catalase / DNA damage / Acute brain ischemia / Cerebrovascular hemoglobin oxygen saturationSource:
Medical Hypotheses, 2020, 134, 109419-Publisher:
- Churchill Livingstone
Funding / projects:
- Hormonal regulation of expression and activity of the nitric oxide synthase and sodium-potassium pump in experimental models of insulin resistance, diabetes and cardiovascular disorders (RS-MESTD-Basic Research (BR or ON)-173033)
- Carotid disease in Serbia - pathologic dynamics, prevention, diagnostics and inovative therapeutic methods (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41002)
- Cell Cycle Aberrations and the Impact of Oxidative Stress in Neurodegenerative Processes and Malignant Transformation of the Cell (RS-MESTD-Basic Research (BR or ON)-173034)
- COST Action [CA15132, ‘hCOMET’]
- KAUST grant [OSR#4129]
- KAUST Base Research Fund [BAS/1/1606-01-01]
- KAUST Office of Sponsored Research (OSR) [FCC/1/1976-17-01]
DOI: 10.1016/j.mehy.2019.109419
ISSN: 0306-9877
PubMed: 31622925
WoS: 000510971500004
Scopus: 2-s2.0-85073096930
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Institution/Community
VinčaTY - JOUR AU - Obradović, Milan M. AU - Zafirović, Sonja AU - Essack, Magbubah AU - Dimitrov, Jelena AU - Živković, Lada AU - Spremo-Potparević, Biljana AU - Radak, Đorđe J. AU - Bajić, Vladimir B. AU - Isenović, Esma R. PY - 2020 UR - https://vinar.vin.bg.ac.rs/handle/123456789/8487 AB - To remedy carotid artery stenosis and prevent stroke surgical intervention is commonly used, and the gold standard being carotid endarterectomy (CEA). During CEA cerebrovascular hemoglobin oxygen saturation decreases and when this decrease reaches critical levels it leads to cerebral hypoxia that causes neuronal damage. One of the proposed mechanism that affects changes during CEA and contribute to acute brain ischemia (ABI) is oxidative stress. The increased production of reactive oxygen species and reactive nitrogen species during ABI may cause an unregulated inflammatory response and further lead to structural and functional injury of neurons. Antioxidant activity are involved in the protection against neuronal damage after cerebral ischemia. We hypothesized that neuronal injury and poor outcomes in patients undergoing CEA may be results of oxidative stress that disturbed function of antioxidant enzymes and contributed to the DNA damage in lymphocytes. © 2019 The Authors PB - Churchill Livingstone T2 - Medical Hypotheses T1 - Antioxidant enzymes expression in lymphocytes of patients undergoing carotid endarterectomy VL - 134 SP - 109419 DO - 10.1016/j.mehy.2019.109419 ER -
@article{ author = "Obradović, Milan M. and Zafirović, Sonja and Essack, Magbubah and Dimitrov, Jelena and Živković, Lada and Spremo-Potparević, Biljana and Radak, Đorđe J. and Bajić, Vladimir B. and Isenović, Esma R.", year = "2020", abstract = "To remedy carotid artery stenosis and prevent stroke surgical intervention is commonly used, and the gold standard being carotid endarterectomy (CEA). During CEA cerebrovascular hemoglobin oxygen saturation decreases and when this decrease reaches critical levels it leads to cerebral hypoxia that causes neuronal damage. One of the proposed mechanism that affects changes during CEA and contribute to acute brain ischemia (ABI) is oxidative stress. The increased production of reactive oxygen species and reactive nitrogen species during ABI may cause an unregulated inflammatory response and further lead to structural and functional injury of neurons. Antioxidant activity are involved in the protection against neuronal damage after cerebral ischemia. We hypothesized that neuronal injury and poor outcomes in patients undergoing CEA may be results of oxidative stress that disturbed function of antioxidant enzymes and contributed to the DNA damage in lymphocytes. © 2019 The Authors", publisher = "Churchill Livingstone", journal = "Medical Hypotheses", title = "Antioxidant enzymes expression in lymphocytes of patients undergoing carotid endarterectomy", volume = "134", pages = "109419", doi = "10.1016/j.mehy.2019.109419" }
Obradović, M. M., Zafirović, S., Essack, M., Dimitrov, J., Živković, L., Spremo-Potparević, B., Radak, Đ. J., Bajić, V. B.,& Isenović, E. R.. (2020). Antioxidant enzymes expression in lymphocytes of patients undergoing carotid endarterectomy. in Medical Hypotheses Churchill Livingstone., 134, 109419. https://doi.org/10.1016/j.mehy.2019.109419
Obradović MM, Zafirović S, Essack M, Dimitrov J, Živković L, Spremo-Potparević B, Radak ĐJ, Bajić VB, Isenović ER. Antioxidant enzymes expression in lymphocytes of patients undergoing carotid endarterectomy. in Medical Hypotheses. 2020;134:109419. doi:10.1016/j.mehy.2019.109419 .
Obradović, Milan M., Zafirović, Sonja, Essack, Magbubah, Dimitrov, Jelena, Živković, Lada, Spremo-Potparević, Biljana, Radak, Đorđe J., Bajić, Vladimir B., Isenović, Esma R., "Antioxidant enzymes expression in lymphocytes of patients undergoing carotid endarterectomy" in Medical Hypotheses, 134 (2020):109419, https://doi.org/10.1016/j.mehy.2019.109419 . .