CXCL16 in Vascular Pathology Research: from Macro Effects to microRNAs
2015
Autori
Jovanović, Ivan G.Živković, Maja
Đurić, Tamara
Popović, Milan
Alavantić, Dragan
Stanković, Aleksandra
Prikaz (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Chemokines and their receptors have become significant factors in atherosclerosis research. CXCL16 is a multifunctional agent located on a separate locus to all other known chemokines and binds only to its unique receptor named CXCR6. As a scavenger receptor, adhesion molecule, and chemokine, it quickly became an interesting target in atherosclerosis research as all its functions have a role in vascular pathology. The investigation of the role of CXCL16 in atherosclerosis, although shown in in vitro studies, animal knockout models, and CXCL16 gene polymorphisms, haplotypes, and circulating levels, still shows puzzling results. Genetic and epigenetic studies have just scratched the surface of research necessary for a better assessment of the significance and perspective of this marker in plaque development and progression. In this review, we will summarize current knowledge about CXCL16 in atherosclerosis. Additionally, we will point out the importance of bioinformatics tools for the de...tection of potentially new CXCL16 regulatory networks through microRNA activity. This review aims to provide a better understanding of the underlying mechanisms, define more specific biomarkers, and discover new therapeutic targets.
Ključne reči:
CXCL16 chemokine / gene / Expression / microRNA / AtherosclerosisIzvor:
Journal of Atherosclerosis and Thrombosis, 2015, 22, 10, 1012-1024Finansiranje / projekti:
- Integralna studija identifikacije regionalnih genetskih faktora rizika i faktora rizika životne sredine za masovne nezarazne bolesti humane populacije u Srbiji - INGEMA_S (RS-41028)
- Genetska osnova humanih vaskularnih i inflamatornih bolesti (RS-175085)
DOI: 10.5551/jat.29942
ISSN: 1340-3478; 1880-3873
PubMed: 26289084
WoS: 000365182000002
Scopus: 2-s2.0-84943264040
Kolekcije
Institucija/grupa
VinčaTY - JOUR AU - Jovanović, Ivan G. AU - Živković, Maja AU - Đurić, Tamara AU - Popović, Milan AU - Alavantić, Dragan AU - Stanković, Aleksandra PY - 2015 UR - https://vinar.vin.bg.ac.rs/handle/123456789/818 AB - Chemokines and their receptors have become significant factors in atherosclerosis research. CXCL16 is a multifunctional agent located on a separate locus to all other known chemokines and binds only to its unique receptor named CXCR6. As a scavenger receptor, adhesion molecule, and chemokine, it quickly became an interesting target in atherosclerosis research as all its functions have a role in vascular pathology. The investigation of the role of CXCL16 in atherosclerosis, although shown in in vitro studies, animal knockout models, and CXCL16 gene polymorphisms, haplotypes, and circulating levels, still shows puzzling results. Genetic and epigenetic studies have just scratched the surface of research necessary for a better assessment of the significance and perspective of this marker in plaque development and progression. In this review, we will summarize current knowledge about CXCL16 in atherosclerosis. Additionally, we will point out the importance of bioinformatics tools for the detection of potentially new CXCL16 regulatory networks through microRNA activity. This review aims to provide a better understanding of the underlying mechanisms, define more specific biomarkers, and discover new therapeutic targets. T2 - Journal of Atherosclerosis and Thrombosis T1 - CXCL16 in Vascular Pathology Research: from Macro Effects to microRNAs VL - 22 IS - 10 SP - 1012 EP - 1024 DO - 10.5551/jat.29942 ER -
@article{ author = "Jovanović, Ivan G. and Živković, Maja and Đurić, Tamara and Popović, Milan and Alavantić, Dragan and Stanković, Aleksandra", year = "2015", abstract = "Chemokines and their receptors have become significant factors in atherosclerosis research. CXCL16 is a multifunctional agent located on a separate locus to all other known chemokines and binds only to its unique receptor named CXCR6. As a scavenger receptor, adhesion molecule, and chemokine, it quickly became an interesting target in atherosclerosis research as all its functions have a role in vascular pathology. The investigation of the role of CXCL16 in atherosclerosis, although shown in in vitro studies, animal knockout models, and CXCL16 gene polymorphisms, haplotypes, and circulating levels, still shows puzzling results. Genetic and epigenetic studies have just scratched the surface of research necessary for a better assessment of the significance and perspective of this marker in plaque development and progression. In this review, we will summarize current knowledge about CXCL16 in atherosclerosis. Additionally, we will point out the importance of bioinformatics tools for the detection of potentially new CXCL16 regulatory networks through microRNA activity. This review aims to provide a better understanding of the underlying mechanisms, define more specific biomarkers, and discover new therapeutic targets.", journal = "Journal of Atherosclerosis and Thrombosis", title = "CXCL16 in Vascular Pathology Research: from Macro Effects to microRNAs", volume = "22", number = "10", pages = "1012-1024", doi = "10.5551/jat.29942" }
Jovanović, I. G., Živković, M., Đurić, T., Popović, M., Alavantić, D.,& Stanković, A.. (2015). CXCL16 in Vascular Pathology Research: from Macro Effects to microRNAs. in Journal of Atherosclerosis and Thrombosis, 22(10), 1012-1024. https://doi.org/10.5551/jat.29942
Jovanović IG, Živković M, Đurić T, Popović M, Alavantić D, Stanković A. CXCL16 in Vascular Pathology Research: from Macro Effects to microRNAs. in Journal of Atherosclerosis and Thrombosis. 2015;22(10):1012-1024. doi:10.5551/jat.29942 .
Jovanović, Ivan G., Živković, Maja, Đurić, Tamara, Popović, Milan, Alavantić, Dragan, Stanković, Aleksandra, "CXCL16 in Vascular Pathology Research: from Macro Effects to microRNAs" in Journal of Atherosclerosis and Thrombosis, 22, no. 10 (2015):1012-1024, https://doi.org/10.5551/jat.29942 . .