Factors effecting the induction of rat forestomach hyperplasia induced by Swedish oral smokeless tobacco (snus)
Autori
Joksić, GordanaRutqvist, Lars Erik
Mićić, Mileva
Filipović Tričković, Jelena G.
Nilsson, Robert
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Long term exposure to oral smokeless tobacco may induce lesions in the oral cavity characterized by a hyperplastic epithelium. The possible role of nicotine and the physical properties of oral tobacco for developing these lesions, as well as of dysplasia and neoplasia is unclear. Low nitrosamine Swedish snus as well as non-genotoxic butylated hydroxyanisole induces increased cellular proliferation in the rat forestomach epithelia. Using this model, we report here on the effects of nicotine, pH, and particle size. Snus with different properties had no impact on oxidative stress as determined by 8-oxo-7,8-dihydro-2′-deoxyguanosine, or on interleukin IL-1b. Whereas BHA boosted IL-6, probably due to the presence of nicotine. there was no significant enhancement of cell divisions with increasing particle size, although in individual samples the variations in proliferation rates increased greatly with increasing particle size. Conforming to human experience, the enhanced cell proliferation c...aused by snus was found to be completely reversible. A cacao bean extract had a protective action similar to that previously found for blueberries. The main cause of the observed tobacco induced cell proliferation could be mechanical irritation, possibly in combination with nicotine, whereas within the studied range, pH did not affect the rate of cell division. © 2019
Ključne reči:
Bromodeoxyuridine / Forestomach / Hyperplasia / Keratosis / Nicotine / Rat / Smokeless tobacco / SnusIzvor:
Regulatory Toxicology and Pharmacology, 2019, 104, 21-28
DOI: 10.1016/j.yrtph.2019.02.015
ISSN: 0273-2300
PubMed: 30844416
WoS: 000476683500004
Scopus: 2-s2.0-85062458272
URI
https://linkinghub.elsevier.com/retrieve/pii/S0273230019300601https://vinar.vin.bg.ac.rs/handle/123456789/8080
Kolekcije
Institucija/grupa
VinčaTY - JOUR AU - Joksić, Gordana AU - Rutqvist, Lars Erik AU - Mićić, Mileva AU - Filipović Tričković, Jelena G. AU - Nilsson, Robert PY - 2019 UR - https://linkinghub.elsevier.com/retrieve/pii/S0273230019300601 UR - https://vinar.vin.bg.ac.rs/handle/123456789/8080 AB - Long term exposure to oral smokeless tobacco may induce lesions in the oral cavity characterized by a hyperplastic epithelium. The possible role of nicotine and the physical properties of oral tobacco for developing these lesions, as well as of dysplasia and neoplasia is unclear. Low nitrosamine Swedish snus as well as non-genotoxic butylated hydroxyanisole induces increased cellular proliferation in the rat forestomach epithelia. Using this model, we report here on the effects of nicotine, pH, and particle size. Snus with different properties had no impact on oxidative stress as determined by 8-oxo-7,8-dihydro-2′-deoxyguanosine, or on interleukin IL-1b. Whereas BHA boosted IL-6, probably due to the presence of nicotine. there was no significant enhancement of cell divisions with increasing particle size, although in individual samples the variations in proliferation rates increased greatly with increasing particle size. Conforming to human experience, the enhanced cell proliferation caused by snus was found to be completely reversible. A cacao bean extract had a protective action similar to that previously found for blueberries. The main cause of the observed tobacco induced cell proliferation could be mechanical irritation, possibly in combination with nicotine, whereas within the studied range, pH did not affect the rate of cell division. © 2019 T2 - Regulatory Toxicology and Pharmacology T1 - Factors effecting the induction of rat forestomach hyperplasia induced by Swedish oral smokeless tobacco (snus) VL - 104 SP - 21 EP - 28 DO - 10.1016/j.yrtph.2019.02.015 ER -
@article{ author = "Joksić, Gordana and Rutqvist, Lars Erik and Mićić, Mileva and Filipović Tričković, Jelena G. and Nilsson, Robert", year = "2019", abstract = "Long term exposure to oral smokeless tobacco may induce lesions in the oral cavity characterized by a hyperplastic epithelium. The possible role of nicotine and the physical properties of oral tobacco for developing these lesions, as well as of dysplasia and neoplasia is unclear. Low nitrosamine Swedish snus as well as non-genotoxic butylated hydroxyanisole induces increased cellular proliferation in the rat forestomach epithelia. Using this model, we report here on the effects of nicotine, pH, and particle size. Snus with different properties had no impact on oxidative stress as determined by 8-oxo-7,8-dihydro-2′-deoxyguanosine, or on interleukin IL-1b. Whereas BHA boosted IL-6, probably due to the presence of nicotine. there was no significant enhancement of cell divisions with increasing particle size, although in individual samples the variations in proliferation rates increased greatly with increasing particle size. Conforming to human experience, the enhanced cell proliferation caused by snus was found to be completely reversible. A cacao bean extract had a protective action similar to that previously found for blueberries. The main cause of the observed tobacco induced cell proliferation could be mechanical irritation, possibly in combination with nicotine, whereas within the studied range, pH did not affect the rate of cell division. © 2019", journal = "Regulatory Toxicology and Pharmacology", title = "Factors effecting the induction of rat forestomach hyperplasia induced by Swedish oral smokeless tobacco (snus)", volume = "104", pages = "21-28", doi = "10.1016/j.yrtph.2019.02.015" }
Joksić, G., Rutqvist, L. E., Mićić, M., Filipović Tričković, J. G.,& Nilsson, R.. (2019). Factors effecting the induction of rat forestomach hyperplasia induced by Swedish oral smokeless tobacco (snus). in Regulatory Toxicology and Pharmacology, 104, 21-28. https://doi.org/10.1016/j.yrtph.2019.02.015
Joksić G, Rutqvist LE, Mićić M, Filipović Tričković JG, Nilsson R. Factors effecting the induction of rat forestomach hyperplasia induced by Swedish oral smokeless tobacco (snus). in Regulatory Toxicology and Pharmacology. 2019;104:21-28. doi:10.1016/j.yrtph.2019.02.015 .
Joksić, Gordana, Rutqvist, Lars Erik, Mićić, Mileva, Filipović Tričković, Jelena G., Nilsson, Robert, "Factors effecting the induction of rat forestomach hyperplasia induced by Swedish oral smokeless tobacco (snus)" in Regulatory Toxicology and Pharmacology, 104 (2019):21-28, https://doi.org/10.1016/j.yrtph.2019.02.015 . .