The role of eNOS and iNOS in pathophysiological conditions
Nema prikaza
Autori
Obradović, Milan M.Zarić, Božidarka
Sudar-Milovanović, Emina
Perović, Milan
Resanović, Ivana
Gluvić, Zoran
Isenović, Esma R.
Poglavlje u monografiji (Objavljena verzija)
,
© Nova Science Publishers
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Nitric oxide (NO) is a free radical which, in reactions with various molecules causes multiple biological effects. NO is exceptionally regulated and extends to almost every cell type and function within circulation. Generation and actions of NO are regulated by various hormones under physiological and pathophysiological conditions. Nitric oxide synthases (NOS) are the enzymes responsible for NO generation. In mammals, neuronal NOS (nNOS) and endothelial NOS (eNOS) are constitutively expressed, while inducible NOS (iNOS) mediate in immune defense. Altered NO level is associated with obesity, insulin resistance (IR), diabetes and cardiovascular diseases (CVD). Disturbances in eNOS and iNOS regulation accompany multiple changes in endothelial function and contribute to development of CVD. Furthermore, key step in initiation and progression of atherosclerosis is reduction in bioactivity of endothelial cell-derived NO. Here we shall focus on recent literature data related to the role of eNO...S and iNOS in physiological and pathophysiological conditions. © 2018 Nova Science Publishers, Inc. All rights reserved.
Ključne reči:
CVD / eNOS / iNOS / NOIzvor:
Horizons in World Cardiovascular Research, 2018, 15, 65-102Izdavač:
- Nova Science Publishers
Kolekcije
Institucija/grupa
VinčaTY - CHAP AU - Obradović, Milan M. AU - Zarić, Božidarka AU - Sudar-Milovanović, Emina AU - Perović, Milan AU - Resanović, Ivana AU - Gluvić, Zoran AU - Isenović, Esma R. PY - 2018 UR - https://vinar.vin.bg.ac.rs/handle/123456789/8014 AB - Nitric oxide (NO) is a free radical which, in reactions with various molecules causes multiple biological effects. NO is exceptionally regulated and extends to almost every cell type and function within circulation. Generation and actions of NO are regulated by various hormones under physiological and pathophysiological conditions. Nitric oxide synthases (NOS) are the enzymes responsible for NO generation. In mammals, neuronal NOS (nNOS) and endothelial NOS (eNOS) are constitutively expressed, while inducible NOS (iNOS) mediate in immune defense. Altered NO level is associated with obesity, insulin resistance (IR), diabetes and cardiovascular diseases (CVD). Disturbances in eNOS and iNOS regulation accompany multiple changes in endothelial function and contribute to development of CVD. Furthermore, key step in initiation and progression of atherosclerosis is reduction in bioactivity of endothelial cell-derived NO. Here we shall focus on recent literature data related to the role of eNOS and iNOS in physiological and pathophysiological conditions. © 2018 Nova Science Publishers, Inc. All rights reserved. PB - Nova Science Publishers T2 - Horizons in World Cardiovascular Research T1 - The role of eNOS and iNOS in pathophysiological conditions VL - 15 SP - 65 EP - 102 UR - https://hdl.handle.net/21.15107/rcub_vinar_8014 ER -
@inbook{ author = "Obradović, Milan M. and Zarić, Božidarka and Sudar-Milovanović, Emina and Perović, Milan and Resanović, Ivana and Gluvić, Zoran and Isenović, Esma R.", year = "2018", abstract = "Nitric oxide (NO) is a free radical which, in reactions with various molecules causes multiple biological effects. NO is exceptionally regulated and extends to almost every cell type and function within circulation. Generation and actions of NO are regulated by various hormones under physiological and pathophysiological conditions. Nitric oxide synthases (NOS) are the enzymes responsible for NO generation. In mammals, neuronal NOS (nNOS) and endothelial NOS (eNOS) are constitutively expressed, while inducible NOS (iNOS) mediate in immune defense. Altered NO level is associated with obesity, insulin resistance (IR), diabetes and cardiovascular diseases (CVD). Disturbances in eNOS and iNOS regulation accompany multiple changes in endothelial function and contribute to development of CVD. Furthermore, key step in initiation and progression of atherosclerosis is reduction in bioactivity of endothelial cell-derived NO. Here we shall focus on recent literature data related to the role of eNOS and iNOS in physiological and pathophysiological conditions. © 2018 Nova Science Publishers, Inc. All rights reserved.", publisher = "Nova Science Publishers", journal = "Horizons in World Cardiovascular Research", booktitle = "The role of eNOS and iNOS in pathophysiological conditions", volume = "15", pages = "65-102", url = "https://hdl.handle.net/21.15107/rcub_vinar_8014" }
Obradović, M. M., Zarić, B., Sudar-Milovanović, E., Perović, M., Resanović, I., Gluvić, Z.,& Isenović, E. R.. (2018). The role of eNOS and iNOS in pathophysiological conditions. in Horizons in World Cardiovascular Research Nova Science Publishers., 15, 65-102. https://hdl.handle.net/21.15107/rcub_vinar_8014
Obradović MM, Zarić B, Sudar-Milovanović E, Perović M, Resanović I, Gluvić Z, Isenović ER. The role of eNOS and iNOS in pathophysiological conditions. in Horizons in World Cardiovascular Research. 2018;15:65-102. https://hdl.handle.net/21.15107/rcub_vinar_8014 .
Obradović, Milan M., Zarić, Božidarka, Sudar-Milovanović, Emina, Perović, Milan, Resanović, Ivana, Gluvić, Zoran, Isenović, Esma R., "The role of eNOS and iNOS in pathophysiological conditions" in Horizons in World Cardiovascular Research, 15 (2018):65-102, https://hdl.handle.net/21.15107/rcub_vinar_8014 .