Relationship between behaviors and catecholamine content in prefrontal cortex and hippocampus of chronically stressed rats
Autori
Popović, Nataša M.Pajović, Snežana B.
Stojiljković, Vesna
Todorović, Ana
Pejić, Snežana
Pavlović, Ivan
Gavrilović, Ljubica
Konferencijski prilog (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Chronic stress induces over-activation and dysfunction of stress-activated systems, resulting in further brain damage and depressive-like behavior. Depression is a potentially life-threatening disorder that affects people and, therefore, it is one of the most important public health problems. This study examined the effects of chronic restraint stress (CRS: 2 hours × 14 days) on the anxiety-like and depression-like behaviors in rats, as well as on the possible changes in the concentrations of dopamine (DA) and noradrenaline (NA) in the prefrontal cortex and hippocampus. We observed a decrease in the number of entries into open arms and time spent in open arms during the elevated plus-maze test (anxiety-like behavior), as well as the increased immobility during the forced swimming test (depression-like behavior). In addition, we found that CRS increases concentration of NA and decreases concentration of DA in the prefrontal cortex and hippocampus. Also, we recorded a significant correla...tion between the animal behavior and levels of neurotransmitters in the prefrontal cortex and hippocampus in stress conditions provoked by CRS. The results presented here suggest that there is a relationship between the animal behavior and levels of neurotransmitters in the prefrontal cortex and hippocampus in stress conditions provoked by CRS, which may be important in the research of numerous psychiatric diseases caused by chronic stress. © RAD Conference Proceedings. All rights reserved.
Ključne reči:
chronic restraint stress / anxiety-like behavior / depression-like behavior / dopamine / noradrenalineIzvor:
RAD Conference Proceedings, 2017, 2, 255-259Izdavač:
- RAD Association
Finansiranje / projekti:
URI
http://www.rad-proceedings.org/paper.php?id=155https://vinar.vin.bg.ac.rs/handle/123456789/7996
Kolekcije
Institucija/grupa
VinčaTY - CONF AU - Popović, Nataša M. AU - Pajović, Snežana B. AU - Stojiljković, Vesna AU - Todorović, Ana AU - Pejić, Snežana AU - Pavlović, Ivan AU - Gavrilović, Ljubica PY - 2017 UR - http://www.rad-proceedings.org/paper.php?id=155 UR - https://vinar.vin.bg.ac.rs/handle/123456789/7996 AB - Chronic stress induces over-activation and dysfunction of stress-activated systems, resulting in further brain damage and depressive-like behavior. Depression is a potentially life-threatening disorder that affects people and, therefore, it is one of the most important public health problems. This study examined the effects of chronic restraint stress (CRS: 2 hours × 14 days) on the anxiety-like and depression-like behaviors in rats, as well as on the possible changes in the concentrations of dopamine (DA) and noradrenaline (NA) in the prefrontal cortex and hippocampus. We observed a decrease in the number of entries into open arms and time spent in open arms during the elevated plus-maze test (anxiety-like behavior), as well as the increased immobility during the forced swimming test (depression-like behavior). In addition, we found that CRS increases concentration of NA and decreases concentration of DA in the prefrontal cortex and hippocampus. Also, we recorded a significant correlation between the animal behavior and levels of neurotransmitters in the prefrontal cortex and hippocampus in stress conditions provoked by CRS. The results presented here suggest that there is a relationship between the animal behavior and levels of neurotransmitters in the prefrontal cortex and hippocampus in stress conditions provoked by CRS, which may be important in the research of numerous psychiatric diseases caused by chronic stress. © RAD Conference Proceedings. All rights reserved. PB - RAD Association C3 - RAD Conference Proceedings T1 - Relationship between behaviors and catecholamine content in prefrontal cortex and hippocampus of chronically stressed rats VL - 2 SP - 255 EP - 259 DO - 10.21175/RadProc.2017.52 ER -
@conference{ author = "Popović, Nataša M. and Pajović, Snežana B. and Stojiljković, Vesna and Todorović, Ana and Pejić, Snežana and Pavlović, Ivan and Gavrilović, Ljubica", year = "2017", abstract = "Chronic stress induces over-activation and dysfunction of stress-activated systems, resulting in further brain damage and depressive-like behavior. Depression is a potentially life-threatening disorder that affects people and, therefore, it is one of the most important public health problems. This study examined the effects of chronic restraint stress (CRS: 2 hours × 14 days) on the anxiety-like and depression-like behaviors in rats, as well as on the possible changes in the concentrations of dopamine (DA) and noradrenaline (NA) in the prefrontal cortex and hippocampus. We observed a decrease in the number of entries into open arms and time spent in open arms during the elevated plus-maze test (anxiety-like behavior), as well as the increased immobility during the forced swimming test (depression-like behavior). In addition, we found that CRS increases concentration of NA and decreases concentration of DA in the prefrontal cortex and hippocampus. Also, we recorded a significant correlation between the animal behavior and levels of neurotransmitters in the prefrontal cortex and hippocampus in stress conditions provoked by CRS. The results presented here suggest that there is a relationship between the animal behavior and levels of neurotransmitters in the prefrontal cortex and hippocampus in stress conditions provoked by CRS, which may be important in the research of numerous psychiatric diseases caused by chronic stress. © RAD Conference Proceedings. All rights reserved.", publisher = "RAD Association", journal = "RAD Conference Proceedings", title = "Relationship between behaviors and catecholamine content in prefrontal cortex and hippocampus of chronically stressed rats", volume = "2", pages = "255-259", doi = "10.21175/RadProc.2017.52" }
Popović, N. M., Pajović, S. B., Stojiljković, V., Todorović, A., Pejić, S., Pavlović, I.,& Gavrilović, L.. (2017). Relationship between behaviors and catecholamine content in prefrontal cortex and hippocampus of chronically stressed rats. in RAD Conference Proceedings RAD Association., 2, 255-259. https://doi.org/10.21175/RadProc.2017.52
Popović NM, Pajović SB, Stojiljković V, Todorović A, Pejić S, Pavlović I, Gavrilović L. Relationship between behaviors and catecholamine content in prefrontal cortex and hippocampus of chronically stressed rats. in RAD Conference Proceedings. 2017;2:255-259. doi:10.21175/RadProc.2017.52 .
Popović, Nataša M., Pajović, Snežana B., Stojiljković, Vesna, Todorović, Ana, Pejić, Snežana, Pavlović, Ivan, Gavrilović, Ljubica, "Relationship between behaviors and catecholamine content in prefrontal cortex and hippocampus of chronically stressed rats" in RAD Conference Proceedings, 2 (2017):255-259, https://doi.org/10.21175/RadProc.2017.52 . .