Role of nonlinear localized Ca2+ pulses along microtubules in tuning the mechano-sensitivity of hair cells
Abstract
This paper aims to provide an overview of the polyelectrolyte model and the current understanding of the creation and propagation of localized pulses of positive ions flowing along cellular microtubules. In that context, Ca2+ ions may move freely on the surface of microtubule along the protofilament axis, thus leading to signal transport. Special emphasis in this paper is placed on the possible role of this mechanism in the function of microtubule based kinocilium, a component of vestibular hair cells of the inner ear. We discuss how localized pulses of Ca2+ ions play a crucial role in tuning the activity of dynein motors, which are involved in mechano sensitivity of the kinocilium. A prevailing notion holds that the concentration of Ca2+ ions around the microtubules within the kinocilium represents the control parameter for Hopf bifurcation. Therefore, a key feature of this mechanism is that the velocities of these Ca2+ pulses be sufficiently high to exert control at acoustic frequenc...ies. (C) 2015 Elsevier Ltd. All rights reserved.
Keywords:
Microtubule / Polyelectrolyte / Calcium ions / Hair cells / Nonlinear ionic pulseSource:
Progress in Biophysics and Molecular Biology, 2015, 119, 2, 162-174Funding / projects:
- Development of the methods, sensors and systems for monitoring quality of water, air and soil (RS-43008)
- The influence of elementary excitations and conformations to physical properties of the new materials based on strongly correlated low-dimensional systems (RS-171009)
- Photonics of micro and nano structured materials (RS-45010)
- Serbian Academy of Sciences and Arts
DOI: 10.1016/j.pbiomolbio.2015.07.009
ISSN: 0079-6107
PubMed: 26208473
WoS: 000363352900005
Scopus: 2-s2.0-84943453631
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Institution/Community
VinčaTY - JOUR AU - Satarić, Miljko V. AU - Sekulić, Dalibor L. AU - Satarić, Bogdan M. AU - Zdravković, Slobodan PY - 2015 UR - https://vinar.vin.bg.ac.rs/handle/123456789/782 AB - This paper aims to provide an overview of the polyelectrolyte model and the current understanding of the creation and propagation of localized pulses of positive ions flowing along cellular microtubules. In that context, Ca2+ ions may move freely on the surface of microtubule along the protofilament axis, thus leading to signal transport. Special emphasis in this paper is placed on the possible role of this mechanism in the function of microtubule based kinocilium, a component of vestibular hair cells of the inner ear. We discuss how localized pulses of Ca2+ ions play a crucial role in tuning the activity of dynein motors, which are involved in mechano sensitivity of the kinocilium. A prevailing notion holds that the concentration of Ca2+ ions around the microtubules within the kinocilium represents the control parameter for Hopf bifurcation. Therefore, a key feature of this mechanism is that the velocities of these Ca2+ pulses be sufficiently high to exert control at acoustic frequencies. (C) 2015 Elsevier Ltd. All rights reserved. T2 - Progress in Biophysics and Molecular Biology T1 - Role of nonlinear localized Ca2+ pulses along microtubules in tuning the mechano-sensitivity of hair cells VL - 119 IS - 2 SP - 162 EP - 174 DO - 10.1016/j.pbiomolbio.2015.07.009 ER -
@article{ author = "Satarić, Miljko V. and Sekulić, Dalibor L. and Satarić, Bogdan M. and Zdravković, Slobodan", year = "2015", abstract = "This paper aims to provide an overview of the polyelectrolyte model and the current understanding of the creation and propagation of localized pulses of positive ions flowing along cellular microtubules. In that context, Ca2+ ions may move freely on the surface of microtubule along the protofilament axis, thus leading to signal transport. Special emphasis in this paper is placed on the possible role of this mechanism in the function of microtubule based kinocilium, a component of vestibular hair cells of the inner ear. We discuss how localized pulses of Ca2+ ions play a crucial role in tuning the activity of dynein motors, which are involved in mechano sensitivity of the kinocilium. A prevailing notion holds that the concentration of Ca2+ ions around the microtubules within the kinocilium represents the control parameter for Hopf bifurcation. Therefore, a key feature of this mechanism is that the velocities of these Ca2+ pulses be sufficiently high to exert control at acoustic frequencies. (C) 2015 Elsevier Ltd. All rights reserved.", journal = "Progress in Biophysics and Molecular Biology", title = "Role of nonlinear localized Ca2+ pulses along microtubules in tuning the mechano-sensitivity of hair cells", volume = "119", number = "2", pages = "162-174", doi = "10.1016/j.pbiomolbio.2015.07.009" }
Satarić, M. V., Sekulić, D. L., Satarić, B. M.,& Zdravković, S.. (2015). Role of nonlinear localized Ca2+ pulses along microtubules in tuning the mechano-sensitivity of hair cells. in Progress in Biophysics and Molecular Biology, 119(2), 162-174. https://doi.org/10.1016/j.pbiomolbio.2015.07.009
Satarić MV, Sekulić DL, Satarić BM, Zdravković S. Role of nonlinear localized Ca2+ pulses along microtubules in tuning the mechano-sensitivity of hair cells. in Progress in Biophysics and Molecular Biology. 2015;119(2):162-174. doi:10.1016/j.pbiomolbio.2015.07.009 .
Satarić, Miljko V., Sekulić, Dalibor L., Satarić, Bogdan M., Zdravković, Slobodan, "Role of nonlinear localized Ca2+ pulses along microtubules in tuning the mechano-sensitivity of hair cells" in Progress in Biophysics and Molecular Biology, 119, no. 2 (2015):162-174, https://doi.org/10.1016/j.pbiomolbio.2015.07.009 . .