Ibuprofen as a template molecule for drug design against Ebola virus
Нема приказа
Аутори
Paessler, SlobodanHuang, Cheng
Senćanski, Milan V.
Veljković, Nevena V.
Perović, Vladimir R.
Glišić, Sanja
Veljković, Veljko
Чланак у часопису (Објављена верзија)
,
© 2018 Frontiers in Bioscience
Метаподаци
Приказ свих података о документуАпстракт
The Ebola virus outbreak in West Africa 2015 and Congo 2017, point out an urgent need for development of drugs against this important pathogen. Previously, by repurposing virtual screening of 6438 drugs from DrugBank, ibuprofen was selected as a possible inhibitor of the Ebola virus infection. The results of an additional docking analysis as well as experimental results showing measurable anti-Ebola effect of ibuprofen in cell culture suggest ibuprofen as a promising molecular template for the development of drugs for treatment of the infection by Ebola virus.
Кључне речи:
drug repositioning / Ebola virus / entry inhibitors / glycoprotein / ibuprofenИзвор:
Frontiers in Bioscience - Landmark, 2018, 23, 5, 947-953Финансирање / пројекти:
- Примена EIIP/ISM биоинформатичке платформе у откривању нових терапеутских таргета и потенцијалних терапеутских молекула (RS-MESTD-Basic Research (BR or ON)-173001)
Колекције
Институција/група
VinčaTY - JOUR AU - Paessler, Slobodan AU - Huang, Cheng AU - Senćanski, Milan V. AU - Veljković, Nevena V. AU - Perović, Vladimir R. AU - Glišić, Sanja AU - Veljković, Veljko PY - 2018 UR - https://vinar.vin.bg.ac.rs/handle/123456789/7695 AB - The Ebola virus outbreak in West Africa 2015 and Congo 2017, point out an urgent need for development of drugs against this important pathogen. Previously, by repurposing virtual screening of 6438 drugs from DrugBank, ibuprofen was selected as a possible inhibitor of the Ebola virus infection. The results of an additional docking analysis as well as experimental results showing measurable anti-Ebola effect of ibuprofen in cell culture suggest ibuprofen as a promising molecular template for the development of drugs for treatment of the infection by Ebola virus. T2 - Frontiers in Bioscience - Landmark T1 - Ibuprofen as a template molecule for drug design against Ebola virus VL - 23 IS - 5 SP - 947 EP - 953 UR - https://hdl.handle.net/21.15107/rcub_vinar_7695 ER -
@article{ author = "Paessler, Slobodan and Huang, Cheng and Senćanski, Milan V. and Veljković, Nevena V. and Perović, Vladimir R. and Glišić, Sanja and Veljković, Veljko", year = "2018", abstract = "The Ebola virus outbreak in West Africa 2015 and Congo 2017, point out an urgent need for development of drugs against this important pathogen. Previously, by repurposing virtual screening of 6438 drugs from DrugBank, ibuprofen was selected as a possible inhibitor of the Ebola virus infection. The results of an additional docking analysis as well as experimental results showing measurable anti-Ebola effect of ibuprofen in cell culture suggest ibuprofen as a promising molecular template for the development of drugs for treatment of the infection by Ebola virus.", journal = "Frontiers in Bioscience - Landmark", title = "Ibuprofen as a template molecule for drug design against Ebola virus", volume = "23", number = "5", pages = "947-953", url = "https://hdl.handle.net/21.15107/rcub_vinar_7695" }
Paessler, S., Huang, C., Senćanski, M. V., Veljković, N. V., Perović, V. R., Glišić, S.,& Veljković, V.. (2018). Ibuprofen as a template molecule for drug design against Ebola virus. in Frontiers in Bioscience - Landmark, 23(5), 947-953. https://hdl.handle.net/21.15107/rcub_vinar_7695
Paessler S, Huang C, Senćanski MV, Veljković NV, Perović VR, Glišić S, Veljković V. Ibuprofen as a template molecule for drug design against Ebola virus. in Frontiers in Bioscience - Landmark. 2018;23(5):947-953. https://hdl.handle.net/21.15107/rcub_vinar_7695 .
Paessler, Slobodan, Huang, Cheng, Senćanski, Milan V., Veljković, Nevena V., Perović, Vladimir R., Glišić, Sanja, Veljković, Veljko, "Ibuprofen as a template molecule for drug design against Ebola virus" in Frontiers in Bioscience - Landmark, 23, no. 5 (2018):947-953, https://hdl.handle.net/21.15107/rcub_vinar_7695 .