MicroRNA meta-signature of oral cancer: evidence from a meta-analysis
Authors
Željić, KatarinaJovanović, Ivan G.
Jovanović, Jasmina
Magić, Zvonko
Stanković, Aleksandra
Šupić, Gordana
Article (Published version)
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Aim: It was the aim of the study to identify commonly deregulated miRNAs in oral cancer patients by performing a meta-analysis of previously published miRNA expression profiles in cancer and matched normal non-cancerous tissue in such patients. Material and methods: Meta-analysis included seven independent studies analyzed by a vote-counting method followed by bioinformatic enrichment analysis. Results: Amongst seven independent studies included in the meta-analysis, 20 miRNAs were found to be deregulated in oral cancer when compared with non-cancerous tissue. Eleven miRNAs were consistently up-regulated in three or more studies (miR-21-5p, miR-31-5p, miR-135b-5p, miR-31-3p, miR-93-5p, miR-34b-5p, miR-424-5p, miR-18a-5p, miR-455-3p, miR-450a-5p, miR-21-3p), and nine were down-regulated (miR-139-5p, miR-30a-3p, miR-376c-3p, miR-885-5p, miR-375, miR-486-5p, miR-411-5p, miR-133a-3p, miR-30a-5p). The meta-signature of identified miRNAs was functionally characterized by KEGG enrichment anal...ysis. Twenty-four KEGG pathways were significantly enriched, and TGF-beta signaling was the most enriched signaling pathway. The highest number of meta-signature miRNAs was involved in the sphingolipid signaling pathway. Natural killer cell-mediated cytotoxicity was the pathway with most genes regulated by identified miRNAs. The rest of the enriched pathways in our miRNA list describe different malignancies and signaling. Conclusions: The identified miRNA meta-signature might be considered as a potential battery of biomarkers when distinguishing oral cancer tissue from normal, non-cancerous tissue. Further mechanistic studies are warranted in order to confirm and fully elucidate the role of deregulated miRNAs in oral cancer.
Keywords:
enrichment analysis / meta-analysis / meta-signature / miRNA / oral cancerSource:
Upsala Journal of Medical Sciences, 2018, 123, 1, 43-49Funding / projects:
- Genetic basis of human vascular and inflammatory diseases (RS-MESTD-Basic Research (BR or ON)-175085)
- Faculty of Medicine, Military Medical Academy, Belgrade, Serbia [MFVMA/11/16-18]
Note:
- Supplemental data at https://doi.org/10.6084/m9.figshare.5926675
DOI: 10.1080/03009734.2018.1439551
ISSN: 0300-9734; 2000-1967
PubMed: 29482431
WoS: 000428060300005
Scopus: 2-s2.0-85042931110
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https://www.tandfonline.com/doi/full/10.1080/03009734.2018.1439551https://vinar.vin.bg.ac.rs/handle/123456789/7630
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VinčaTY - JOUR AU - Željić, Katarina AU - Jovanović, Ivan G. AU - Jovanović, Jasmina AU - Magić, Zvonko AU - Stanković, Aleksandra AU - Šupić, Gordana PY - 2018 UR - https://www.tandfonline.com/doi/full/10.1080/03009734.2018.1439551 UR - https://vinar.vin.bg.ac.rs/handle/123456789/7630 AB - Aim: It was the aim of the study to identify commonly deregulated miRNAs in oral cancer patients by performing a meta-analysis of previously published miRNA expression profiles in cancer and matched normal non-cancerous tissue in such patients. Material and methods: Meta-analysis included seven independent studies analyzed by a vote-counting method followed by bioinformatic enrichment analysis. Results: Amongst seven independent studies included in the meta-analysis, 20 miRNAs were found to be deregulated in oral cancer when compared with non-cancerous tissue. Eleven miRNAs were consistently up-regulated in three or more studies (miR-21-5p, miR-31-5p, miR-135b-5p, miR-31-3p, miR-93-5p, miR-34b-5p, miR-424-5p, miR-18a-5p, miR-455-3p, miR-450a-5p, miR-21-3p), and nine were down-regulated (miR-139-5p, miR-30a-3p, miR-376c-3p, miR-885-5p, miR-375, miR-486-5p, miR-411-5p, miR-133a-3p, miR-30a-5p). The meta-signature of identified miRNAs was functionally characterized by KEGG enrichment analysis. Twenty-four KEGG pathways were significantly enriched, and TGF-beta signaling was the most enriched signaling pathway. The highest number of meta-signature miRNAs was involved in the sphingolipid signaling pathway. Natural killer cell-mediated cytotoxicity was the pathway with most genes regulated by identified miRNAs. The rest of the enriched pathways in our miRNA list describe different malignancies and signaling. Conclusions: The identified miRNA meta-signature might be considered as a potential battery of biomarkers when distinguishing oral cancer tissue from normal, non-cancerous tissue. Further mechanistic studies are warranted in order to confirm and fully elucidate the role of deregulated miRNAs in oral cancer. T2 - Upsala Journal of Medical Sciences T1 - MicroRNA meta-signature of oral cancer: evidence from a meta-analysis VL - 123 IS - 1 SP - 43 EP - 49 DO - 10.1080/03009734.2018.1439551 ER -
@article{ author = "Željić, Katarina and Jovanović, Ivan G. and Jovanović, Jasmina and Magić, Zvonko and Stanković, Aleksandra and Šupić, Gordana", year = "2018", abstract = "Aim: It was the aim of the study to identify commonly deregulated miRNAs in oral cancer patients by performing a meta-analysis of previously published miRNA expression profiles in cancer and matched normal non-cancerous tissue in such patients. Material and methods: Meta-analysis included seven independent studies analyzed by a vote-counting method followed by bioinformatic enrichment analysis. Results: Amongst seven independent studies included in the meta-analysis, 20 miRNAs were found to be deregulated in oral cancer when compared with non-cancerous tissue. Eleven miRNAs were consistently up-regulated in three or more studies (miR-21-5p, miR-31-5p, miR-135b-5p, miR-31-3p, miR-93-5p, miR-34b-5p, miR-424-5p, miR-18a-5p, miR-455-3p, miR-450a-5p, miR-21-3p), and nine were down-regulated (miR-139-5p, miR-30a-3p, miR-376c-3p, miR-885-5p, miR-375, miR-486-5p, miR-411-5p, miR-133a-3p, miR-30a-5p). The meta-signature of identified miRNAs was functionally characterized by KEGG enrichment analysis. Twenty-four KEGG pathways were significantly enriched, and TGF-beta signaling was the most enriched signaling pathway. The highest number of meta-signature miRNAs was involved in the sphingolipid signaling pathway. Natural killer cell-mediated cytotoxicity was the pathway with most genes regulated by identified miRNAs. The rest of the enriched pathways in our miRNA list describe different malignancies and signaling. Conclusions: The identified miRNA meta-signature might be considered as a potential battery of biomarkers when distinguishing oral cancer tissue from normal, non-cancerous tissue. Further mechanistic studies are warranted in order to confirm and fully elucidate the role of deregulated miRNAs in oral cancer.", journal = "Upsala Journal of Medical Sciences", title = "MicroRNA meta-signature of oral cancer: evidence from a meta-analysis", volume = "123", number = "1", pages = "43-49", doi = "10.1080/03009734.2018.1439551" }
Željić, K., Jovanović, I. G., Jovanović, J., Magić, Z., Stanković, A.,& Šupić, G.. (2018). MicroRNA meta-signature of oral cancer: evidence from a meta-analysis. in Upsala Journal of Medical Sciences, 123(1), 43-49. https://doi.org/10.1080/03009734.2018.1439551
Željić K, Jovanović IG, Jovanović J, Magić Z, Stanković A, Šupić G. MicroRNA meta-signature of oral cancer: evidence from a meta-analysis. in Upsala Journal of Medical Sciences. 2018;123(1):43-49. doi:10.1080/03009734.2018.1439551 .
Željić, Katarina, Jovanović, Ivan G., Jovanović, Jasmina, Magić, Zvonko, Stanković, Aleksandra, Šupić, Gordana, "MicroRNA meta-signature of oral cancer: evidence from a meta-analysis" in Upsala Journal of Medical Sciences, 123, no. 1 (2018):43-49, https://doi.org/10.1080/03009734.2018.1439551 . .