RS10757278 from 9P21 is associated with st-elevated myocardial infarction in females in population of Serbia
Samo za registrovane korisnike
2017
Autori
Životić, IvanŽivković, Maja
Đurić, Tamara
Stanković, Aleksandra
Đorđević, Ana
Dekleva, Milica
Marković-Nikolić, Nevena
Alavantić, Dragan
Konferencijski prilog (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Aim: Myocardial infarction (MI) is the clinical complication predominately
caused by coronary plaque buildup and rupture during the process of
atherosclerosis. In the 9p21 locus two important risk haplotype blocks
have been identified. The one that carries the risk for MI with the lead
variant rs10757278 and another characterized to influence progression of
the MI, with the lead variant rs518394. We have investigated association of
the two genetic variants with the ST-elevated MI in the gender specific
manner. We have also tested variants effect on p15 mRNA level as one of
the possible mechanisms of the variants effect.Methods: The study group included 147 patients (72 females) with angiographically assessed MI, and 240 healthy controls (90 females). DNA
and RNA (n¼28) where isolated from peripheral blood mono nuclear
leukocytes. Genotypes for rs10757278 A/G and rs518394 C/G, and relative
mRNA level for p15 were determined using commercial TaqMan® assays
on 7500 ABI Real-Ti...me PCR.
Results: We have found significant association of rs10757278 GG with STelevated MI occurrence, with OR of 2.2 (CI¼1.07-4.5, p¼0.03) in females.
P15 mRNA was significantly down-regulated in G allele carriers (AG+GG vs
AA) by a mean factor of 0.449 (S.E. range is 0.188-1.059), p¼0.019 in the
whole group. The genetic variant rs518394 was not significantly associated
either with MI or p15 mRNA level.
Conclusions: Genotype GG of rs10757278 is significantly associated with
MI occurrence in females in Serbian population. On
Izvor:
Atherosclerosis, 2017, 263, e188-e188Napomena:
- 85th Congress of the European-Atherosclerosis-Society (EAS), Apr 23-26, 2017, Prague, Czech Republic
DOI: 10.1016/j.atherosclerosis.2017.06.603
ISSN: 0021-9150; 1879-1484
PubMed: 29365726
WoS: 000407634000566
[ Google Scholar ]Kolekcije
Institucija/grupa
VinčaTY - CONF AU - Životić, Ivan AU - Živković, Maja AU - Đurić, Tamara AU - Stanković, Aleksandra AU - Đorđević, Ana AU - Dekleva, Milica AU - Marković-Nikolić, Nevena AU - Alavantić, Dragan PY - 2017 UR - https://vinar.vin.bg.ac.rs/handle/123456789/7178 AB - Aim: Myocardial infarction (MI) is the clinical complication predominately caused by coronary plaque buildup and rupture during the process of atherosclerosis. In the 9p21 locus two important risk haplotype blocks have been identified. The one that carries the risk for MI with the lead variant rs10757278 and another characterized to influence progression of the MI, with the lead variant rs518394. We have investigated association of the two genetic variants with the ST-elevated MI in the gender specific manner. We have also tested variants effect on p15 mRNA level as one of the possible mechanisms of the variants effect.Methods: The study group included 147 patients (72 females) with angiographically assessed MI, and 240 healthy controls (90 females). DNA and RNA (n¼28) where isolated from peripheral blood mono nuclear leukocytes. Genotypes for rs10757278 A/G and rs518394 C/G, and relative mRNA level for p15 were determined using commercial TaqMan® assays on 7500 ABI Real-Time PCR. Results: We have found significant association of rs10757278 GG with STelevated MI occurrence, with OR of 2.2 (CI¼1.07-4.5, p¼0.03) in females. P15 mRNA was significantly down-regulated in G allele carriers (AG+GG vs AA) by a mean factor of 0.449 (S.E. range is 0.188-1.059), p¼0.019 in the whole group. The genetic variant rs518394 was not significantly associated either with MI or p15 mRNA level. Conclusions: Genotype GG of rs10757278 is significantly associated with MI occurrence in females in Serbian population. On C3 - Atherosclerosis T1 - RS10757278 from 9P21 is associated with st-elevated myocardial infarction in females in population of Serbia VL - 263 SP - e188 EP - e188 DO - 10.1016/j.atherosclerosis.2017.06.603 ER -
@conference{ author = "Životić, Ivan and Živković, Maja and Đurić, Tamara and Stanković, Aleksandra and Đorđević, Ana and Dekleva, Milica and Marković-Nikolić, Nevena and Alavantić, Dragan", year = "2017", abstract = "Aim: Myocardial infarction (MI) is the clinical complication predominately caused by coronary plaque buildup and rupture during the process of atherosclerosis. In the 9p21 locus two important risk haplotype blocks have been identified. The one that carries the risk for MI with the lead variant rs10757278 and another characterized to influence progression of the MI, with the lead variant rs518394. We have investigated association of the two genetic variants with the ST-elevated MI in the gender specific manner. We have also tested variants effect on p15 mRNA level as one of the possible mechanisms of the variants effect.Methods: The study group included 147 patients (72 females) with angiographically assessed MI, and 240 healthy controls (90 females). DNA and RNA (n¼28) where isolated from peripheral blood mono nuclear leukocytes. Genotypes for rs10757278 A/G and rs518394 C/G, and relative mRNA level for p15 were determined using commercial TaqMan® assays on 7500 ABI Real-Time PCR. Results: We have found significant association of rs10757278 GG with STelevated MI occurrence, with OR of 2.2 (CI¼1.07-4.5, p¼0.03) in females. P15 mRNA was significantly down-regulated in G allele carriers (AG+GG vs AA) by a mean factor of 0.449 (S.E. range is 0.188-1.059), p¼0.019 in the whole group. The genetic variant rs518394 was not significantly associated either with MI or p15 mRNA level. Conclusions: Genotype GG of rs10757278 is significantly associated with MI occurrence in females in Serbian population. On", journal = "Atherosclerosis", title = "RS10757278 from 9P21 is associated with st-elevated myocardial infarction in females in population of Serbia", volume = "263", pages = "e188-e188", doi = "10.1016/j.atherosclerosis.2017.06.603" }
Životić, I., Živković, M., Đurić, T., Stanković, A., Đorđević, A., Dekleva, M., Marković-Nikolić, N.,& Alavantić, D.. (2017). RS10757278 from 9P21 is associated with st-elevated myocardial infarction in females in population of Serbia. in Atherosclerosis, 263, e188-e188. https://doi.org/10.1016/j.atherosclerosis.2017.06.603
Životić I, Živković M, Đurić T, Stanković A, Đorđević A, Dekleva M, Marković-Nikolić N, Alavantić D. RS10757278 from 9P21 is associated with st-elevated myocardial infarction in females in population of Serbia. in Atherosclerosis. 2017;263:e188-e188. doi:10.1016/j.atherosclerosis.2017.06.603 .
Životić, Ivan, Živković, Maja, Đurić, Tamara, Stanković, Aleksandra, Đorđević, Ana, Dekleva, Milica, Marković-Nikolić, Nevena, Alavantić, Dragan, "RS10757278 from 9P21 is associated with st-elevated myocardial infarction in females in population of Serbia" in Atherosclerosis, 263 (2017):e188-e188, https://doi.org/10.1016/j.atherosclerosis.2017.06.603 . .