Antioxidant Capacity of the Kidney Tissue in Patients with Renal Cell Carcinoma
Autori
Pavlović, IvanTodorović, Ana
Stojiljković, Vesna
Gavrilović, Ljubica
Popović, Nataša M.
Pajović, Snežana B.
Pejić, Snežana
Konferencijski prilog (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Renal cell carcinoma is the most common and the most lethal type of kidney cancer with the highest incidence in developed countries. At the moment of diagnosis, many patients already have developed metastases. Tobacco smoking, obesity, hypertension and occupational exposure are established risk factors. Superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) are antioxidant enzymes (AOE) that have a key role in protecting from reactive oxygen species (ROS) produced in pathological processes. We examined the antioxidant capacity of tumour tissue in patients with clear cell type of renal cell carcinoma. The results showed a significant decrease of AOE activities in the tumour tissue compared to the normal kidney tissue, indicating that the tumour tissue is under permanent oxidative stress. Renal cell carcinoma is highly resistant to radiation therapy, which is also associated with free radical production. Since the tumour tissue has impaired AO capacity, the findings ...of this study may contribute to the improvement of the potential therapeutic treatments.
Ključne reči:
Oxidative stress / antioxidant enzymes / kidney cancerIzvor:
RAD Conference Proceedings, 2016, 153-155Finansiranje / projekti:
- Ćelijske i molekulske osnove malignih i kardiovaskularnih oboljenja-kliničke implikacije (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41027)
Napomena:
- 4th International Conference on Radiation and Applications in Various Fields of Research (RAD), Proceedings, May 23-27, 2016, Nis, Serbia
DOI: 10.21175/RadProc.2016.36
ISSN: 2466-4626
WoS: 000403671400036
Scopus: 2-s2.0-85058053544
Kolekcije
Institucija/grupa
VinčaTY - CONF AU - Pavlović, Ivan AU - Todorović, Ana AU - Stojiljković, Vesna AU - Gavrilović, Ljubica AU - Popović, Nataša M. AU - Pajović, Snežana B. AU - Pejić, Snežana PY - 2016 UR - https://vinar.vin.bg.ac.rs/handle/123456789/7171 AB - Renal cell carcinoma is the most common and the most lethal type of kidney cancer with the highest incidence in developed countries. At the moment of diagnosis, many patients already have developed metastases. Tobacco smoking, obesity, hypertension and occupational exposure are established risk factors. Superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) are antioxidant enzymes (AOE) that have a key role in protecting from reactive oxygen species (ROS) produced in pathological processes. We examined the antioxidant capacity of tumour tissue in patients with clear cell type of renal cell carcinoma. The results showed a significant decrease of AOE activities in the tumour tissue compared to the normal kidney tissue, indicating that the tumour tissue is under permanent oxidative stress. Renal cell carcinoma is highly resistant to radiation therapy, which is also associated with free radical production. Since the tumour tissue has impaired AO capacity, the findings of this study may contribute to the improvement of the potential therapeutic treatments. C3 - RAD Conference Proceedings T1 - Antioxidant Capacity of the Kidney Tissue in Patients with Renal Cell Carcinoma SP - 153 EP - 155 DO - 10.21175/RadProc.2016.36 ER -
@conference{ author = "Pavlović, Ivan and Todorović, Ana and Stojiljković, Vesna and Gavrilović, Ljubica and Popović, Nataša M. and Pajović, Snežana B. and Pejić, Snežana", year = "2016", abstract = "Renal cell carcinoma is the most common and the most lethal type of kidney cancer with the highest incidence in developed countries. At the moment of diagnosis, many patients already have developed metastases. Tobacco smoking, obesity, hypertension and occupational exposure are established risk factors. Superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) are antioxidant enzymes (AOE) that have a key role in protecting from reactive oxygen species (ROS) produced in pathological processes. We examined the antioxidant capacity of tumour tissue in patients with clear cell type of renal cell carcinoma. The results showed a significant decrease of AOE activities in the tumour tissue compared to the normal kidney tissue, indicating that the tumour tissue is under permanent oxidative stress. Renal cell carcinoma is highly resistant to radiation therapy, which is also associated with free radical production. Since the tumour tissue has impaired AO capacity, the findings of this study may contribute to the improvement of the potential therapeutic treatments.", journal = "RAD Conference Proceedings", title = "Antioxidant Capacity of the Kidney Tissue in Patients with Renal Cell Carcinoma", pages = "153-155", doi = "10.21175/RadProc.2016.36" }
Pavlović, I., Todorović, A., Stojiljković, V., Gavrilović, L., Popović, N. M., Pajović, S. B.,& Pejić, S.. (2016). Antioxidant Capacity of the Kidney Tissue in Patients with Renal Cell Carcinoma. in RAD Conference Proceedings, 153-155. https://doi.org/10.21175/RadProc.2016.36
Pavlović I, Todorović A, Stojiljković V, Gavrilović L, Popović NM, Pajović SB, Pejić S. Antioxidant Capacity of the Kidney Tissue in Patients with Renal Cell Carcinoma. in RAD Conference Proceedings. 2016;:153-155. doi:10.21175/RadProc.2016.36 .
Pavlović, Ivan, Todorović, Ana, Stojiljković, Vesna, Gavrilović, Ljubica, Popović, Nataša M., Pajović, Snežana B., Pejić, Snežana, "Antioxidant Capacity of the Kidney Tissue in Patients with Renal Cell Carcinoma" in RAD Conference Proceedings (2016):153-155, https://doi.org/10.21175/RadProc.2016.36 . .