Antioxidant Enzymes in Women with Hyperplasia Complex: Relation with Sex Hormones
Autori
Pejić, SnežanaTodorović, Ana
Stojiljković, Vesna
Gavrilović, Ljubica
Popović, Nataša M.
Pavlović, Ivan
Pajović, Snežana B.
Konferencijski prilog (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Endometrial hyperplasia complex is gynecological disorder characterized by morphological irregularities of glands shape and size. Antioxidant enzymes (AOE), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR), have an essential role in preventing oxidative damage in cell caused by reactive oxygen species (ROS). In this study, we examined the AO status in hyperplastic tissue of patients in menstrual cycle (follicular and luteal phase) and in postmenopause, as well as the relationship between sex hormones and AO parameters. The phase-related activity of GPx and GR in examined patients was significantly different than in healthy women. A significant negative correlation between FSH/LH level and GPx activiy was observed. Endometrial hyperplasias are considered as precancerous lesions and are treated either conservatively or surgicaly, and also by radiation therapy. Since the effects of these therapies are associated with AO and hormonal c...hanges, our results may contribute to the prediction of potential therapeutic efficacy and to selection of the most effective treatment for hyperplasia complex.
Ključne reči:
endometrial hyperplasia / antioxidant enzymes / steroid hormonesIzvor:
RAD Conference Proceedings, 2015, 467-470Finansiranje / projekti:
- Ćelijske i molekulske osnove malignih i kardiovaskularnih oboljenja-kliničke implikacije (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41027)
- Akutni koronarni sindrom: istraživanje vulnerabilnosti (plaka, krvi i miokarda), optimalno lečenje i određivanje prognostičkih faktora (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41022)
- Molekularno fiziološki biomonitoring aerobnih organizama zasnovan na određivanju biohemijskih biomarkera oksidacionog stresa (RS-MESTD-Basic Research (BR or ON)-173041)
Napomena:
- 3rd International Conference on Radiation and Applications in Various Fields of Research (RAD), Jun 08-12, 2015, Budva, Montenegro
Kolekcije
Institucija/grupa
VinčaTY - CONF AU - Pejić, Snežana AU - Todorović, Ana AU - Stojiljković, Vesna AU - Gavrilović, Ljubica AU - Popović, Nataša M. AU - Pavlović, Ivan AU - Pajović, Snežana B. PY - 2015 UR - https://vinar.vin.bg.ac.rs/handle/123456789/7131 AB - Endometrial hyperplasia complex is gynecological disorder characterized by morphological irregularities of glands shape and size. Antioxidant enzymes (AOE), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR), have an essential role in preventing oxidative damage in cell caused by reactive oxygen species (ROS). In this study, we examined the AO status in hyperplastic tissue of patients in menstrual cycle (follicular and luteal phase) and in postmenopause, as well as the relationship between sex hormones and AO parameters. The phase-related activity of GPx and GR in examined patients was significantly different than in healthy women. A significant negative correlation between FSH/LH level and GPx activiy was observed. Endometrial hyperplasias are considered as precancerous lesions and are treated either conservatively or surgicaly, and also by radiation therapy. Since the effects of these therapies are associated with AO and hormonal changes, our results may contribute to the prediction of potential therapeutic efficacy and to selection of the most effective treatment for hyperplasia complex. C3 - RAD Conference Proceedings T1 - Antioxidant Enzymes in Women with Hyperplasia Complex: Relation with Sex Hormones SP - 467 EP - 470 UR - https://hdl.handle.net/21.15107/rcub_vinar_7131 ER -
@conference{ author = "Pejić, Snežana and Todorović, Ana and Stojiljković, Vesna and Gavrilović, Ljubica and Popović, Nataša M. and Pavlović, Ivan and Pajović, Snežana B.", year = "2015", abstract = "Endometrial hyperplasia complex is gynecological disorder characterized by morphological irregularities of glands shape and size. Antioxidant enzymes (AOE), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR), have an essential role in preventing oxidative damage in cell caused by reactive oxygen species (ROS). In this study, we examined the AO status in hyperplastic tissue of patients in menstrual cycle (follicular and luteal phase) and in postmenopause, as well as the relationship between sex hormones and AO parameters. The phase-related activity of GPx and GR in examined patients was significantly different than in healthy women. A significant negative correlation between FSH/LH level and GPx activiy was observed. Endometrial hyperplasias are considered as precancerous lesions and are treated either conservatively or surgicaly, and also by radiation therapy. Since the effects of these therapies are associated with AO and hormonal changes, our results may contribute to the prediction of potential therapeutic efficacy and to selection of the most effective treatment for hyperplasia complex.", journal = "RAD Conference Proceedings", title = "Antioxidant Enzymes in Women with Hyperplasia Complex: Relation with Sex Hormones", pages = "467-470", url = "https://hdl.handle.net/21.15107/rcub_vinar_7131" }
Pejić, S., Todorović, A., Stojiljković, V., Gavrilović, L., Popović, N. M., Pavlović, I.,& Pajović, S. B.. (2015). Antioxidant Enzymes in Women with Hyperplasia Complex: Relation with Sex Hormones. in RAD Conference Proceedings, 467-470. https://hdl.handle.net/21.15107/rcub_vinar_7131
Pejić S, Todorović A, Stojiljković V, Gavrilović L, Popović NM, Pavlović I, Pajović SB. Antioxidant Enzymes in Women with Hyperplasia Complex: Relation with Sex Hormones. in RAD Conference Proceedings. 2015;:467-470. https://hdl.handle.net/21.15107/rcub_vinar_7131 .
Pejić, Snežana, Todorović, Ana, Stojiljković, Vesna, Gavrilović, Ljubica, Popović, Nataša M., Pavlović, Ivan, Pajović, Snežana B., "Antioxidant Enzymes in Women with Hyperplasia Complex: Relation with Sex Hormones" in RAD Conference Proceedings (2015):467-470, https://hdl.handle.net/21.15107/rcub_vinar_7131 .