The effect of subchronic supplementation with folic acid and L-arginine on homocysteine-induced seizures
Нема приказа
Аутори
Rašić-Marković, AleksandraHrnčić, Dragan
Krstić, Danijela Z.
Čolović, Mirjana B.
Djuric, E.
Rankov-Petrovic, B.
Šušić, Veselinka
Stanojlović, Olivera
Đurić, Dragan M.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The aim of the present study was to examine the effect of subchronic co-administration of folic acid (F) and L-arginine (A) on behavioural and electroencephalographic (EEG) characteristics of DL homocysteine thiolactone (H) induced seizures in adult rats. The activity of membrane ATPases in different brain regions were also investigated. Rats were treated with F, A, or vehicle for 15 days (regimen: F 5 mg/kg + A 500 mg/kg (F5A500); F 10 mg/kg + A 300 mg/kg (F10A300)). Seizures were elicited by convulsive dose of H (H, F5A500H, F10A300H) Subchronic supplementation with F and A did not affect seizure incidence, number of seizure episodes, and severity in F5A500H and F10A300H groups vs. H group. However, a tendency to increase latency and decrease the number of seizure episodes was noticed in the F10A300H group. EEG mean spectral power densities during ictal periods were significantly lower in F10A300H vs. H group. The activity of Na+/K+-ATPase and Mg2+-ATPase was significantly increased ...in almost all examined structures in rats treated with F and A. We can conclude that subchronic supplementation with folic acid and L-arginine has an antiepileptic effect in DL homocysteine thiolactone induced epilepsy.
Кључне речи:
folic acid / L-arginine / DL homocysteine thiolactone / seizures / EEG / Na+/K+-ATPase / Mg2+-ATPase / ratsИзвор:
Canadian Journal of Physiology and Pharmacology, 2016, 94, 10, 1083-1089Напомена:
- 2nd European-Section Meeting of the International-Academy-of-Cardiovascular-Sciences (IACS), Oct 08-10, 2015, Belgrade, Serbia
DOI: 10.1139/cjpp-2016-0076
ISSN: 0008-4212; 1205-7541
WoS: 000385444900008
Scopus: 2-s2.0-84989898682
Колекције
Институција/група
VinčaTY - JOUR AU - Rašić-Marković, Aleksandra AU - Hrnčić, Dragan AU - Krstić, Danijela Z. AU - Čolović, Mirjana B. AU - Djuric, E. AU - Rankov-Petrovic, B. AU - Šušić, Veselinka AU - Stanojlović, Olivera AU - Đurić, Dragan M. PY - 2016 UR - https://vinar.vin.bg.ac.rs/handle/123456789/7114 AB - The aim of the present study was to examine the effect of subchronic co-administration of folic acid (F) and L-arginine (A) on behavioural and electroencephalographic (EEG) characteristics of DL homocysteine thiolactone (H) induced seizures in adult rats. The activity of membrane ATPases in different brain regions were also investigated. Rats were treated with F, A, or vehicle for 15 days (regimen: F 5 mg/kg + A 500 mg/kg (F5A500); F 10 mg/kg + A 300 mg/kg (F10A300)). Seizures were elicited by convulsive dose of H (H, F5A500H, F10A300H) Subchronic supplementation with F and A did not affect seizure incidence, number of seizure episodes, and severity in F5A500H and F10A300H groups vs. H group. However, a tendency to increase latency and decrease the number of seizure episodes was noticed in the F10A300H group. EEG mean spectral power densities during ictal periods were significantly lower in F10A300H vs. H group. The activity of Na+/K+-ATPase and Mg2+-ATPase was significantly increased in almost all examined structures in rats treated with F and A. We can conclude that subchronic supplementation with folic acid and L-arginine has an antiepileptic effect in DL homocysteine thiolactone induced epilepsy. T2 - Canadian Journal of Physiology and Pharmacology T1 - The effect of subchronic supplementation with folic acid and L-arginine on homocysteine-induced seizures VL - 94 IS - 10 SP - 1083 EP - 1089 DO - 10.1139/cjpp-2016-0076 ER -
@article{ author = "Rašić-Marković, Aleksandra and Hrnčić, Dragan and Krstić, Danijela Z. and Čolović, Mirjana B. and Djuric, E. and Rankov-Petrovic, B. and Šušić, Veselinka and Stanojlović, Olivera and Đurić, Dragan M.", year = "2016", abstract = "The aim of the present study was to examine the effect of subchronic co-administration of folic acid (F) and L-arginine (A) on behavioural and electroencephalographic (EEG) characteristics of DL homocysteine thiolactone (H) induced seizures in adult rats. The activity of membrane ATPases in different brain regions were also investigated. Rats were treated with F, A, or vehicle for 15 days (regimen: F 5 mg/kg + A 500 mg/kg (F5A500); F 10 mg/kg + A 300 mg/kg (F10A300)). Seizures were elicited by convulsive dose of H (H, F5A500H, F10A300H) Subchronic supplementation with F and A did not affect seizure incidence, number of seizure episodes, and severity in F5A500H and F10A300H groups vs. H group. However, a tendency to increase latency and decrease the number of seizure episodes was noticed in the F10A300H group. EEG mean spectral power densities during ictal periods were significantly lower in F10A300H vs. H group. The activity of Na+/K+-ATPase and Mg2+-ATPase was significantly increased in almost all examined structures in rats treated with F and A. We can conclude that subchronic supplementation with folic acid and L-arginine has an antiepileptic effect in DL homocysteine thiolactone induced epilepsy.", journal = "Canadian Journal of Physiology and Pharmacology", title = "The effect of subchronic supplementation with folic acid and L-arginine on homocysteine-induced seizures", volume = "94", number = "10", pages = "1083-1089", doi = "10.1139/cjpp-2016-0076" }
Rašić-Marković, A., Hrnčić, D., Krstić, D. Z., Čolović, M. B., Djuric, E., Rankov-Petrovic, B., Šušić, V., Stanojlović, O.,& Đurić, D. M.. (2016). The effect of subchronic supplementation with folic acid and L-arginine on homocysteine-induced seizures. in Canadian Journal of Physiology and Pharmacology, 94(10), 1083-1089. https://doi.org/10.1139/cjpp-2016-0076
Rašić-Marković A, Hrnčić D, Krstić DZ, Čolović MB, Djuric E, Rankov-Petrovic B, Šušić V, Stanojlović O, Đurić DM. The effect of subchronic supplementation with folic acid and L-arginine on homocysteine-induced seizures. in Canadian Journal of Physiology and Pharmacology. 2016;94(10):1083-1089. doi:10.1139/cjpp-2016-0076 .
Rašić-Marković, Aleksandra, Hrnčić, Dragan, Krstić, Danijela Z., Čolović, Mirjana B., Djuric, E., Rankov-Petrovic, B., Šušić, Veselinka, Stanojlović, Olivera, Đurić, Dragan M., "The effect of subchronic supplementation with folic acid and L-arginine on homocysteine-induced seizures" in Canadian Journal of Physiology and Pharmacology, 94, no. 10 (2016):1083-1089, https://doi.org/10.1139/cjpp-2016-0076 . .