Improving attrition rates in Ebola virus drug discovery
Nema prikaza
Autori
Glišić, SanjaPaessler, Slobodan
Veljković, Nevena V.
Perović, Vladimir R.
Prljić, Jelena
Veljković, Veljko
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Introduction: The Ebola 2014/2015 outbreak has had devastating effects on the people living in West Africa. The spread of the disease in endemic countries and the potential introduction of sporadic cases in other continents points out the global health threat of Ebola virus disease (EVD). Despite the urgent need for treating EVD, there are no approved treatments. Given the lack of treatments available, alternative therapeutic strategies have had to be used. Areas covered: This article summarizes the unregistered therapeutics that were used to treat patients during the Ebola 2014/2015 outbreak, in addition to approaches used for the selection of candidate drugs. The article also proposes potential theoretical criterion for use in virtual screening of molecular libraries for candidate Ebola drugs. Expert opinion: In the absence of approved therapeutics for EVD, experimental drugs have had to be used. The repurposing of approved drugs for the treatment of EVD, as an alternative therapeuti...c strategy, has also been suggested. Screening in vitro- and in sllico-approved drugs revealed several promising candidates but further testing is required to test their efficacy. All these therapeutic approaches are, however, only short-term solutions and there is still an urgent need for the development of specific drugs for the current and future outbreaks.
Ključne reči:
drug discovery / Ebola virus / virtual screeningIzvor:
Expert Opinion on Drug Discovery, 2015, 10, 9, 1025-1032Finansiranje / projekti:
- Primena EIIP/ISM bioinformatičke platforme u otkrivanju novih terapeutskih targeta i potencijalnih terapeutskih molekula (RS-MESTD-Basic Research (BR or ON)-173001)
DOI: 10.1517/17460441.2015.1062872
ISSN: 1746-0441; 1746-045X
PubMed: 26125997
WoS: 000360185200007
Scopus: 2-s2.0-84938943006
Kolekcije
Institucija/grupa
VinčaTY - JOUR AU - Glišić, Sanja AU - Paessler, Slobodan AU - Veljković, Nevena V. AU - Perović, Vladimir R. AU - Prljić, Jelena AU - Veljković, Veljko PY - 2015 UR - https://vinar.vin.bg.ac.rs/handle/123456789/709 AB - Introduction: The Ebola 2014/2015 outbreak has had devastating effects on the people living in West Africa. The spread of the disease in endemic countries and the potential introduction of sporadic cases in other continents points out the global health threat of Ebola virus disease (EVD). Despite the urgent need for treating EVD, there are no approved treatments. Given the lack of treatments available, alternative therapeutic strategies have had to be used. Areas covered: This article summarizes the unregistered therapeutics that were used to treat patients during the Ebola 2014/2015 outbreak, in addition to approaches used for the selection of candidate drugs. The article also proposes potential theoretical criterion for use in virtual screening of molecular libraries for candidate Ebola drugs. Expert opinion: In the absence of approved therapeutics for EVD, experimental drugs have had to be used. The repurposing of approved drugs for the treatment of EVD, as an alternative therapeutic strategy, has also been suggested. Screening in vitro- and in sllico-approved drugs revealed several promising candidates but further testing is required to test their efficacy. All these therapeutic approaches are, however, only short-term solutions and there is still an urgent need for the development of specific drugs for the current and future outbreaks. T2 - Expert Opinion on Drug Discovery T1 - Improving attrition rates in Ebola virus drug discovery VL - 10 IS - 9 SP - 1025 EP - 1032 DO - 10.1517/17460441.2015.1062872 ER -
@article{ author = "Glišić, Sanja and Paessler, Slobodan and Veljković, Nevena V. and Perović, Vladimir R. and Prljić, Jelena and Veljković, Veljko", year = "2015", abstract = "Introduction: The Ebola 2014/2015 outbreak has had devastating effects on the people living in West Africa. The spread of the disease in endemic countries and the potential introduction of sporadic cases in other continents points out the global health threat of Ebola virus disease (EVD). Despite the urgent need for treating EVD, there are no approved treatments. Given the lack of treatments available, alternative therapeutic strategies have had to be used. Areas covered: This article summarizes the unregistered therapeutics that were used to treat patients during the Ebola 2014/2015 outbreak, in addition to approaches used for the selection of candidate drugs. The article also proposes potential theoretical criterion for use in virtual screening of molecular libraries for candidate Ebola drugs. Expert opinion: In the absence of approved therapeutics for EVD, experimental drugs have had to be used. The repurposing of approved drugs for the treatment of EVD, as an alternative therapeutic strategy, has also been suggested. Screening in vitro- and in sllico-approved drugs revealed several promising candidates but further testing is required to test their efficacy. All these therapeutic approaches are, however, only short-term solutions and there is still an urgent need for the development of specific drugs for the current and future outbreaks.", journal = "Expert Opinion on Drug Discovery", title = "Improving attrition rates in Ebola virus drug discovery", volume = "10", number = "9", pages = "1025-1032", doi = "10.1517/17460441.2015.1062872" }
Glišić, S., Paessler, S., Veljković, N. V., Perović, V. R., Prljić, J.,& Veljković, V.. (2015). Improving attrition rates in Ebola virus drug discovery. in Expert Opinion on Drug Discovery, 10(9), 1025-1032. https://doi.org/10.1517/17460441.2015.1062872
Glišić S, Paessler S, Veljković NV, Perović VR, Prljić J, Veljković V. Improving attrition rates in Ebola virus drug discovery. in Expert Opinion on Drug Discovery. 2015;10(9):1025-1032. doi:10.1517/17460441.2015.1062872 .
Glišić, Sanja, Paessler, Slobodan, Veljković, Nevena V., Perović, Vladimir R., Prljić, Jelena, Veljković, Veljko, "Improving attrition rates in Ebola virus drug discovery" in Expert Opinion on Drug Discovery, 10, no. 9 (2015):1025-1032, https://doi.org/10.1517/17460441.2015.1062872 . .