Proton inactivation of melanoma cells enhanced by fotemustine
Samo za registrovane korisnike
2011
Autori
Ristić-Fira, AleksandraKorićanac, Lela
Žakula, Jelena
Keta, Otilija D.
Iannolo, Gioacchin
Cuttone, Giacomo
Petrović, Ivan M.
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Response of human HTB140 melanoma cells to proton irradiation in combination with fotemustine (FM) was investigated. Effects of these agents were analysed on cell proliferation and induction of apoptosis. Cells pretreated with 100- or 250-mu M of FM were irradiated in the middle of the therapeutic 62-MeV proton spread-out Bragg peak, with a dose of 16 Gy. All treatments reduced proliferation and survival of melanoma cells. The most pronounced effects of the combined treatment were obtained for cell survivals. The level of apoptosis increased after all applied treatments. Particularly good pro-apoptotic effect was achieved when proton irradiation was combined with 250 mu M of FM. This was followed by the increased expression of p53 gene. The obtained results have shown that combined application of FM and protons significantly reduced growth of this resistant melanoma cell line.
Izvor:
Radiation Protection Dosimetry, 2011, 143, 2-4, 503-507Finansiranje / projekti:
- Eksperimentalna fizika visokih energija na detektoru CMS u CERN-u (RS-MESTD-MPN2006-2010-141038)
- Signalni putevi delovanja steroidnih hormona i uticaj endogenih i egzogenih faktora na modulaciju procesa u ćelijama sisara (RS-MESTD-MPN2006-2010-143044)
Napomena:
- 15th International Symposium on Microdosimetry, Oct 25-30, 2009, Verona, Italy
DOI: 10.1093/rpd/ncq527
ISSN: 0144-8420
PubMed: 21183545
WoS: 000288022300073
Scopus: 2-s2.0-79952331780
Institucija/grupa
VinčaTY - JOUR AU - Ristić-Fira, Aleksandra AU - Korićanac, Lela AU - Žakula, Jelena AU - Keta, Otilija D. AU - Iannolo, Gioacchin AU - Cuttone, Giacomo AU - Petrović, Ivan M. PY - 2011 UR - https://vinar.vin.bg.ac.rs/handle/123456789/6905 AB - Response of human HTB140 melanoma cells to proton irradiation in combination with fotemustine (FM) was investigated. Effects of these agents were analysed on cell proliferation and induction of apoptosis. Cells pretreated with 100- or 250-mu M of FM were irradiated in the middle of the therapeutic 62-MeV proton spread-out Bragg peak, with a dose of 16 Gy. All treatments reduced proliferation and survival of melanoma cells. The most pronounced effects of the combined treatment were obtained for cell survivals. The level of apoptosis increased after all applied treatments. Particularly good pro-apoptotic effect was achieved when proton irradiation was combined with 250 mu M of FM. This was followed by the increased expression of p53 gene. The obtained results have shown that combined application of FM and protons significantly reduced growth of this resistant melanoma cell line. T2 - Radiation Protection Dosimetry T1 - Proton inactivation of melanoma cells enhanced by fotemustine VL - 143 IS - 2-4 SP - 503 EP - 507 DO - 10.1093/rpd/ncq527 ER -
@article{ author = "Ristić-Fira, Aleksandra and Korićanac, Lela and Žakula, Jelena and Keta, Otilija D. and Iannolo, Gioacchin and Cuttone, Giacomo and Petrović, Ivan M.", year = "2011", abstract = "Response of human HTB140 melanoma cells to proton irradiation in combination with fotemustine (FM) was investigated. Effects of these agents were analysed on cell proliferation and induction of apoptosis. Cells pretreated with 100- or 250-mu M of FM were irradiated in the middle of the therapeutic 62-MeV proton spread-out Bragg peak, with a dose of 16 Gy. All treatments reduced proliferation and survival of melanoma cells. The most pronounced effects of the combined treatment were obtained for cell survivals. The level of apoptosis increased after all applied treatments. Particularly good pro-apoptotic effect was achieved when proton irradiation was combined with 250 mu M of FM. This was followed by the increased expression of p53 gene. The obtained results have shown that combined application of FM and protons significantly reduced growth of this resistant melanoma cell line.", journal = "Radiation Protection Dosimetry", title = "Proton inactivation of melanoma cells enhanced by fotemustine", volume = "143", number = "2-4", pages = "503-507", doi = "10.1093/rpd/ncq527" }
Ristić-Fira, A., Korićanac, L., Žakula, J., Keta, O. D., Iannolo, G., Cuttone, G.,& Petrović, I. M.. (2011). Proton inactivation of melanoma cells enhanced by fotemustine. in Radiation Protection Dosimetry, 143(2-4), 503-507. https://doi.org/10.1093/rpd/ncq527
Ristić-Fira A, Korićanac L, Žakula J, Keta OD, Iannolo G, Cuttone G, Petrović IM. Proton inactivation of melanoma cells enhanced by fotemustine. in Radiation Protection Dosimetry. 2011;143(2-4):503-507. doi:10.1093/rpd/ncq527 .
Ristić-Fira, Aleksandra, Korićanac, Lela, Žakula, Jelena, Keta, Otilija D., Iannolo, Gioacchin, Cuttone, Giacomo, Petrović, Ivan M., "Proton inactivation of melanoma cells enhanced by fotemustine" in Radiation Protection Dosimetry, 143, no. 2-4 (2011):503-507, https://doi.org/10.1093/rpd/ncq527 . .