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Time-dependent inhibition of Na+/K+-ATPase induced by single and simultaneous exposure to lead and cadmium
dc.creator | Vasić, Vesna M. | |
dc.creator | Kojić, Dušan | |
dc.creator | Krinulović, Katarina | |
dc.creator | Čolović, Mirjana B. | |
dc.creator | Vujačić, Ana V. | |
dc.creator | Stojić, Dragica Lj. | |
dc.date.accessioned | 2018-03-03T14:28:23Z | |
dc.date.available | 2018-03-03T14:28:23Z | |
dc.date.issued | 2007 | |
dc.identifier.issn | 0036-0244 | |
dc.identifier.issn | 1531-863X | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/6719 | |
dc.description.abstract | Time-dependent interactions of Na+/K+-ATPase, isolated from rat brain synaptic plasma membranes (SPMs), with Cd2+ and Pb2+ ions in a single exposure and in a mixture were investigated in vitro. The interference of the enzyme with these metal ions was studied as a function of different protein concentrations and exposure time. The aim of the work was to investigate the possibility of selective recognition of Cd2+ and Pb2+ ions in a mixture, on the basis of the different rates of their protein-ligand interactions. Decreasing protein concentration increased the sensitivity of Na+/K+-ATPase toward both metals. The selectivity in protein-ligand interactions was obtained by variation of preincubation time (incubation before starting the enzymatic reaction). | en |
dc.rights | restrictedAccess | en |
dc.source | Russian Journal of Physical Chemistry A | en |
dc.title | Time-dependent inhibition of Na+/K+-ATPase induced by single and simultaneous exposure to lead and cadmium | en |
dc.type | article | en |
dcterms.abstract | Васић Весна М; Стојиц, Д.; Кринуловиц, К.; Којиц, Д.; Вујачић-Никезић Aна; Чоловић Мирјана; | |
dc.citation.volume | 81 | |
dc.citation.issue | 9 | |
dc.citation.spage | 1402 | |
dc.citation.epage | 1406 | |
dc.identifier.wos | 000253706400010 | |
dc.identifier.doi | 10.1134/S0036024407090105 | |
dc.citation.rank | M23 | |
dc.description.other | 8th International Conference on Fundamental and Applied Aspects of Physical Chemistry, Sep 26-29, 2006, Belgrade, Serbia | en |
dc.identifier.scopus | 2-s2.0-34548497579 |
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