Time-dependent inhibition of Na+/K+-ATPase induced by single and simultaneous exposure to lead and cadmium
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Vasić, Vesna M.Kojić, Dušan
Krinulović, Katarina
Čolović, Mirjana B.
Vujačić, Ana V.
Stojić, Dragica Lj.
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Time-dependent interactions of Na+/K+-ATPase, isolated from rat brain synaptic plasma membranes (SPMs), with Cd2+ and Pb2+ ions in a single exposure and in a mixture were investigated in vitro. The interference of the enzyme with these metal ions was studied as a function of different protein concentrations and exposure time. The aim of the work was to investigate the possibility of selective recognition of Cd2+ and Pb2+ ions in a mixture, on the basis of the different rates of their protein-ligand interactions. Decreasing protein concentration increased the sensitivity of Na+/K+-ATPase toward both metals. The selectivity in protein-ligand interactions was obtained by variation of preincubation time (incubation before starting the enzymatic reaction).
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Russian Journal of Physical Chemistry A, 2007, 81, 9, 1402-1406Note:
- 8th International Conference on Fundamental and Applied Aspects of Physical Chemistry, Sep 26-29, 2006, Belgrade, Serbia
DOI: 10.1134/S0036024407090105
ISSN: 0036-0244; 1531-863X
WoS: 000253706400010
Scopus: 2-s2.0-34548497579
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VinčaTY - JOUR AU - Vasić, Vesna M. AU - Kojić, Dušan AU - Krinulović, Katarina AU - Čolović, Mirjana B. AU - Vujačić, Ana V. AU - Stojić, Dragica Lj. PY - 2007 UR - https://vinar.vin.bg.ac.rs/handle/123456789/6719 AB - Time-dependent interactions of Na+/K+-ATPase, isolated from rat brain synaptic plasma membranes (SPMs), with Cd2+ and Pb2+ ions in a single exposure and in a mixture were investigated in vitro. The interference of the enzyme with these metal ions was studied as a function of different protein concentrations and exposure time. The aim of the work was to investigate the possibility of selective recognition of Cd2+ and Pb2+ ions in a mixture, on the basis of the different rates of their protein-ligand interactions. Decreasing protein concentration increased the sensitivity of Na+/K+-ATPase toward both metals. The selectivity in protein-ligand interactions was obtained by variation of preincubation time (incubation before starting the enzymatic reaction). T2 - Russian Journal of Physical Chemistry A T1 - Time-dependent inhibition of Na+/K+-ATPase induced by single and simultaneous exposure to lead and cadmium VL - 81 IS - 9 SP - 1402 EP - 1406 DO - 10.1134/S0036024407090105 ER -
@article{ author = "Vasić, Vesna M. and Kojić, Dušan and Krinulović, Katarina and Čolović, Mirjana B. and Vujačić, Ana V. and Stojić, Dragica Lj.", year = "2007", abstract = "Time-dependent interactions of Na+/K+-ATPase, isolated from rat brain synaptic plasma membranes (SPMs), with Cd2+ and Pb2+ ions in a single exposure and in a mixture were investigated in vitro. The interference of the enzyme with these metal ions was studied as a function of different protein concentrations and exposure time. The aim of the work was to investigate the possibility of selective recognition of Cd2+ and Pb2+ ions in a mixture, on the basis of the different rates of their protein-ligand interactions. Decreasing protein concentration increased the sensitivity of Na+/K+-ATPase toward both metals. The selectivity in protein-ligand interactions was obtained by variation of preincubation time (incubation before starting the enzymatic reaction).", journal = "Russian Journal of Physical Chemistry A", title = "Time-dependent inhibition of Na+/K+-ATPase induced by single and simultaneous exposure to lead and cadmium", volume = "81", number = "9", pages = "1402-1406", doi = "10.1134/S0036024407090105" }
Vasić, V. M., Kojić, D., Krinulović, K., Čolović, M. B., Vujačić, A. V.,& Stojić, D. Lj.. (2007). Time-dependent inhibition of Na+/K+-ATPase induced by single and simultaneous exposure to lead and cadmium. in Russian Journal of Physical Chemistry A, 81(9), 1402-1406. https://doi.org/10.1134/S0036024407090105
Vasić VM, Kojić D, Krinulović K, Čolović MB, Vujačić AV, Stojić DL. Time-dependent inhibition of Na+/K+-ATPase induced by single and simultaneous exposure to lead and cadmium. in Russian Journal of Physical Chemistry A. 2007;81(9):1402-1406. doi:10.1134/S0036024407090105 .
Vasić, Vesna M., Kojić, Dušan, Krinulović, Katarina, Čolović, Mirjana B., Vujačić, Ana V., Stojić, Dragica Lj., "Time-dependent inhibition of Na+/K+-ATPase induced by single and simultaneous exposure to lead and cadmium" in Russian Journal of Physical Chemistry A, 81, no. 9 (2007):1402-1406, https://doi.org/10.1134/S0036024407090105 . .