The stabilizer influence on morphological characteristics of poly-(DL-lactide-co-glycolide) nanospheres
Abstract
Copolymer poly(D,L-lactide-co-glycolide) is used for obtaining the systems for controlled delivery of medicaments. Its specific characteristics make it suitable for various researches where its synthesis is performed in different ways. Using the system for controlled delivery of medicaments, an equal concentration of the medicament is achieved in the body throughout an extended period of time and it has advantages over the conventional methods. In this paper we present a new solvent/non-solvent chemical method for obtaining DLPLG nanospheres. In the experiment various stabilizers were used in order to examine their influence on morphological characteristics of DLPLG particles. The samples were characterized by Infrared Spectroscopy (IR), Differential Scanning Calorimetry (DSC), Scanning Electron Microscopy (SEM) and Stereological analysis.
Keywords:
drug delivery / nanospheres / poly-(DL-lactide-co-glycolide) / polyvinyl alcohol / polyvinyl pyrrolidone / stabilizers / stereological analysisSource:
Materials Science Forum, 2007, 555, 447-+Note:
- Research Trends in Contemporary Materials Science, 8th Conference of the Yugoslav-Materials-Research-Society (Yu-MRS), Sep 04-08, 2006, Herceg Novi, Montenegro
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VinčaTY - CONF AU - Stevanović, M. AU - Jordovic, B. AU - Nedić, Zoran AU - Miličević, Dejan S. PY - 2007 UR - https://vinar.vin.bg.ac.rs/handle/123456789/6696 AB - Copolymer poly(D,L-lactide-co-glycolide) is used for obtaining the systems for controlled delivery of medicaments. Its specific characteristics make it suitable for various researches where its synthesis is performed in different ways. Using the system for controlled delivery of medicaments, an equal concentration of the medicament is achieved in the body throughout an extended period of time and it has advantages over the conventional methods. In this paper we present a new solvent/non-solvent chemical method for obtaining DLPLG nanospheres. In the experiment various stabilizers were used in order to examine their influence on morphological characteristics of DLPLG particles. The samples were characterized by Infrared Spectroscopy (IR), Differential Scanning Calorimetry (DSC), Scanning Electron Microscopy (SEM) and Stereological analysis. C3 - Materials Science Forum T1 - The stabilizer influence on morphological characteristics of poly-(DL-lactide-co-glycolide) nanospheres VL - 555 SP - 447 EP - + DO - 10.4028/www.scientific.net/MSF.555.447 ER -
@conference{ author = "Stevanović, M. and Jordovic, B. and Nedić, Zoran and Miličević, Dejan S.", year = "2007", abstract = "Copolymer poly(D,L-lactide-co-glycolide) is used for obtaining the systems for controlled delivery of medicaments. Its specific characteristics make it suitable for various researches where its synthesis is performed in different ways. Using the system for controlled delivery of medicaments, an equal concentration of the medicament is achieved in the body throughout an extended period of time and it has advantages over the conventional methods. In this paper we present a new solvent/non-solvent chemical method for obtaining DLPLG nanospheres. In the experiment various stabilizers were used in order to examine their influence on morphological characteristics of DLPLG particles. The samples were characterized by Infrared Spectroscopy (IR), Differential Scanning Calorimetry (DSC), Scanning Electron Microscopy (SEM) and Stereological analysis.", journal = "Materials Science Forum", title = "The stabilizer influence on morphological characteristics of poly-(DL-lactide-co-glycolide) nanospheres", volume = "555", pages = "447-+", doi = "10.4028/www.scientific.net/MSF.555.447" }
Stevanović, M., Jordovic, B., Nedić, Z.,& Miličević, D. S.. (2007). The stabilizer influence on morphological characteristics of poly-(DL-lactide-co-glycolide) nanospheres. in Materials Science Forum, 555, 447-+. https://doi.org/10.4028/www.scientific.net/MSF.555.447
Stevanović M, Jordovic B, Nedić Z, Miličević DS. The stabilizer influence on morphological characteristics of poly-(DL-lactide-co-glycolide) nanospheres. in Materials Science Forum. 2007;555:447-+. doi:10.4028/www.scientific.net/MSF.555.447 .
Stevanović, M., Jordovic, B., Nedić, Zoran, Miličević, Dejan S., "The stabilizer influence on morphological characteristics of poly-(DL-lactide-co-glycolide) nanospheres" in Materials Science Forum, 555 (2007):447-+, https://doi.org/10.4028/www.scientific.net/MSF.555.447 . .