A theoretical study-of hypothalamo-pituitary adrenocortical axis dynamics
Апстракт
Does the hypothalamo-pituitary-adrenocortical (HPA) axis itself generate oscillations? The affirmative answer to this question is commonly assumed, because a regular daily rhythm of its hormones is observed. We offer another plausible explanation of the origin of this pattern: HPA just responds to an external pacemaker. A qualitative mathematical model is constructed wherein all the terms in the equations are physicochemically interpretable. Linear stability analysis shows that this system does not generate oscillations. Computer simulation yields oscillations that are the systems response to an external pulsing activator, implying that the observed pattern does not have to be an intrinsic property of this system.
Кључне речи:
hypothalamo-pituitary-adrenocortical (HPA) axis / circadian rhythm / nonlinear dynamics / stability analysisИзвор:
Annals of the New York Academy of Sciences, 2005, 1048, 430-432Напомена:
- 22nd International Biophysics Symposium, Oct 09-14, 2004, Belgrade, Serbia
DOI: 10.1196/annals.1342.055
ISSN: 0077-8923
PubMed: 16154968
WoS: 000233712300052
Scopus: 2-s2.0-25144448594
Колекције
Институција/група
VinčaTY - JOUR AU - Savić, Danka A. AU - Jelić, Smiljana PY - 2005 UR - https://vinar.vin.bg.ac.rs/handle/123456789/6555 AB - Does the hypothalamo-pituitary-adrenocortical (HPA) axis itself generate oscillations? The affirmative answer to this question is commonly assumed, because a regular daily rhythm of its hormones is observed. We offer another plausible explanation of the origin of this pattern: HPA just responds to an external pacemaker. A qualitative mathematical model is constructed wherein all the terms in the equations are physicochemically interpretable. Linear stability analysis shows that this system does not generate oscillations. Computer simulation yields oscillations that are the systems response to an external pulsing activator, implying that the observed pattern does not have to be an intrinsic property of this system. T2 - Annals of the New York Academy of Sciences T1 - A theoretical study-of hypothalamo-pituitary adrenocortical axis dynamics VL - 1048 SP - 430 EP - 432 DO - 10.1196/annals.1342.055 ER -
@article{ author = "Savić, Danka A. and Jelić, Smiljana", year = "2005", abstract = "Does the hypothalamo-pituitary-adrenocortical (HPA) axis itself generate oscillations? The affirmative answer to this question is commonly assumed, because a regular daily rhythm of its hormones is observed. We offer another plausible explanation of the origin of this pattern: HPA just responds to an external pacemaker. A qualitative mathematical model is constructed wherein all the terms in the equations are physicochemically interpretable. Linear stability analysis shows that this system does not generate oscillations. Computer simulation yields oscillations that are the systems response to an external pulsing activator, implying that the observed pattern does not have to be an intrinsic property of this system.", journal = "Annals of the New York Academy of Sciences", title = "A theoretical study-of hypothalamo-pituitary adrenocortical axis dynamics", volume = "1048", pages = "430-432", doi = "10.1196/annals.1342.055" }
Savić, D. A.,& Jelić, S.. (2005). A theoretical study-of hypothalamo-pituitary adrenocortical axis dynamics. in Annals of the New York Academy of Sciences, 1048, 430-432. https://doi.org/10.1196/annals.1342.055
Savić DA, Jelić S. A theoretical study-of hypothalamo-pituitary adrenocortical axis dynamics. in Annals of the New York Academy of Sciences. 2005;1048:430-432. doi:10.1196/annals.1342.055 .
Savić, Danka A., Jelić, Smiljana, "A theoretical study-of hypothalamo-pituitary adrenocortical axis dynamics" in Annals of the New York Academy of Sciences, 1048 (2005):430-432, https://doi.org/10.1196/annals.1342.055 . .