Differences in antioxidative response of rat hippocampus and cortex after exposure to clinical dose of gamma-rays
Abstract
Ionizing radiation increases intracellular production of reactive oxygen species, which can damage cell structure and function. The brain is particularly vulnerable to oxidative injury, and in an area-dependent manner. In order to elucidate differences in enzymatic antioxidative response of rat hippocampus and cortex, we measured activities of CuZnSOD, MnSOD, and CAT in those two brain regions, isolated 1h and 24 h after exposure to 2 Gy of gamma-rays. Our results indicate that lower MnSOD activities and inducibility, found in the hippocampus, are probably some of the main reasons for the particularly great oxidative vulnerability of this brain region.
Keywords:
hippocampus / cortex / radiation / rat / superoxide dismutase / catalaseSource:
Annals of the New York Academy of Sciences, 2005, 1048, 369-372Note:
- 22nd International Biophysics Symposium, Oct 09-14, 2004, Belgrade, Serbia
DOI: 10.1196/annals.1342.041
ISSN: 0077-8923
PubMed: 16154955
WoS: 000233712300039
Scopus: 2-s2.0-25144433307
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VinčaTY - JOUR AU - Todorović, Ana AU - Kasapović, Jelena AU - Pejić, Snežana AU - Stojiljković, Vesna AU - Pajović, Snežana B. PY - 2005 UR - https://vinar.vin.bg.ac.rs/handle/123456789/6553 AB - Ionizing radiation increases intracellular production of reactive oxygen species, which can damage cell structure and function. The brain is particularly vulnerable to oxidative injury, and in an area-dependent manner. In order to elucidate differences in enzymatic antioxidative response of rat hippocampus and cortex, we measured activities of CuZnSOD, MnSOD, and CAT in those two brain regions, isolated 1h and 24 h after exposure to 2 Gy of gamma-rays. Our results indicate that lower MnSOD activities and inducibility, found in the hippocampus, are probably some of the main reasons for the particularly great oxidative vulnerability of this brain region. T2 - Annals of the New York Academy of Sciences T1 - Differences in antioxidative response of rat hippocampus and cortex after exposure to clinical dose of gamma-rays VL - 1048 SP - 369 EP - 372 DO - 10.1196/annals.1342.041 ER -
@article{ author = "Todorović, Ana and Kasapović, Jelena and Pejić, Snežana and Stojiljković, Vesna and Pajović, Snežana B.", year = "2005", abstract = "Ionizing radiation increases intracellular production of reactive oxygen species, which can damage cell structure and function. The brain is particularly vulnerable to oxidative injury, and in an area-dependent manner. In order to elucidate differences in enzymatic antioxidative response of rat hippocampus and cortex, we measured activities of CuZnSOD, MnSOD, and CAT in those two brain regions, isolated 1h and 24 h after exposure to 2 Gy of gamma-rays. Our results indicate that lower MnSOD activities and inducibility, found in the hippocampus, are probably some of the main reasons for the particularly great oxidative vulnerability of this brain region.", journal = "Annals of the New York Academy of Sciences", title = "Differences in antioxidative response of rat hippocampus and cortex after exposure to clinical dose of gamma-rays", volume = "1048", pages = "369-372", doi = "10.1196/annals.1342.041" }
Todorović, A., Kasapović, J., Pejić, S., Stojiljković, V.,& Pajović, S. B.. (2005). Differences in antioxidative response of rat hippocampus and cortex after exposure to clinical dose of gamma-rays. in Annals of the New York Academy of Sciences, 1048, 369-372. https://doi.org/10.1196/annals.1342.041
Todorović A, Kasapović J, Pejić S, Stojiljković V, Pajović SB. Differences in antioxidative response of rat hippocampus and cortex after exposure to clinical dose of gamma-rays. in Annals of the New York Academy of Sciences. 2005;1048:369-372. doi:10.1196/annals.1342.041 .
Todorović, Ana, Kasapović, Jelena, Pejić, Snežana, Stojiljković, Vesna, Pajović, Snežana B., "Differences in antioxidative response of rat hippocampus and cortex after exposure to clinical dose of gamma-rays" in Annals of the New York Academy of Sciences, 1048 (2005):369-372, https://doi.org/10.1196/annals.1342.041 . .