Photochemical degradation of solid-state nisoldipine monitored by HPLC
Nema prikaza
Autori
Marinković, Valentina D.Agbaba, Danica
Karjikovic-Rajic, K
Vladimirov, Sote
Nedeljković, Jovan
Članak u časopisu
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The photochemical degradation of solid-state nisoldipine, 1,4-dihydropyridine calcium antagonist, was investigated under daylight and UV light conditions. Degradation products were identified by using the retention times of corresponding standards and quantified by high-performance liquid chromatographic method. The daylight illumination induced appearance of nitrosophenylpyridine, while formation of second degradation product, nitrophenylpyridine, was observed only upon UV light illumination. The photodegradation kinetics of solid-state nisoldipine under daylight and UV light illumination belongs to class of zero-order reactions. The rate constants of disappearance of nisoldipine upon illumination were determined for raw material as well as pharmaceuticals (tablets, film-tablets and capsules). (C) 2003 Elsevier Science B.V. All rights reserved.
Ključne reči:
nisoldipine / photochemical degradation / illuminationIzvor:
Journal of Pharmaceutical and Biomedical Analysis, 2003, 32, 4-5, 929-935Napomena:
- Joint Meeting of the 7th International Symposium on Drug Analysis/13th International Symposium on Pharmaceutical and Biomedial Analysis, Apr 21-25, 2002, Brugge, Belgium
DOI: 10.1016/S0731-7085(03)00194-8
ISSN: 0731-7085
PubMed: 12899979
WoS: 000184881600034
Scopus: 2-s2.0-0041623025
Kolekcije
Institucija/grupa
VinčaTY - JOUR AU - Marinković, Valentina D. AU - Agbaba, Danica AU - Karjikovic-Rajic, K AU - Vladimirov, Sote AU - Nedeljković, Jovan PY - 2003 UR - https://vinar.vin.bg.ac.rs/handle/123456789/6377 AB - The photochemical degradation of solid-state nisoldipine, 1,4-dihydropyridine calcium antagonist, was investigated under daylight and UV light conditions. Degradation products were identified by using the retention times of corresponding standards and quantified by high-performance liquid chromatographic method. The daylight illumination induced appearance of nitrosophenylpyridine, while formation of second degradation product, nitrophenylpyridine, was observed only upon UV light illumination. The photodegradation kinetics of solid-state nisoldipine under daylight and UV light illumination belongs to class of zero-order reactions. The rate constants of disappearance of nisoldipine upon illumination were determined for raw material as well as pharmaceuticals (tablets, film-tablets and capsules). (C) 2003 Elsevier Science B.V. All rights reserved. T2 - Journal of Pharmaceutical and Biomedical Analysis T1 - Photochemical degradation of solid-state nisoldipine monitored by HPLC VL - 32 IS - 4-5 SP - 929 EP - 935 DO - 10.1016/S0731-7085(03)00194-8 ER -
@article{ author = "Marinković, Valentina D. and Agbaba, Danica and Karjikovic-Rajic, K and Vladimirov, Sote and Nedeljković, Jovan", year = "2003", abstract = "The photochemical degradation of solid-state nisoldipine, 1,4-dihydropyridine calcium antagonist, was investigated under daylight and UV light conditions. Degradation products were identified by using the retention times of corresponding standards and quantified by high-performance liquid chromatographic method. The daylight illumination induced appearance of nitrosophenylpyridine, while formation of second degradation product, nitrophenylpyridine, was observed only upon UV light illumination. The photodegradation kinetics of solid-state nisoldipine under daylight and UV light illumination belongs to class of zero-order reactions. The rate constants of disappearance of nisoldipine upon illumination were determined for raw material as well as pharmaceuticals (tablets, film-tablets and capsules). (C) 2003 Elsevier Science B.V. All rights reserved.", journal = "Journal of Pharmaceutical and Biomedical Analysis", title = "Photochemical degradation of solid-state nisoldipine monitored by HPLC", volume = "32", number = "4-5", pages = "929-935", doi = "10.1016/S0731-7085(03)00194-8" }
Marinković, V. D., Agbaba, D., Karjikovic-Rajic, K., Vladimirov, S.,& Nedeljković, J.. (2003). Photochemical degradation of solid-state nisoldipine monitored by HPLC. in Journal of Pharmaceutical and Biomedical Analysis, 32(4-5), 929-935. https://doi.org/10.1016/S0731-7085(03)00194-8
Marinković VD, Agbaba D, Karjikovic-Rajic K, Vladimirov S, Nedeljković J. Photochemical degradation of solid-state nisoldipine monitored by HPLC. in Journal of Pharmaceutical and Biomedical Analysis. 2003;32(4-5):929-935. doi:10.1016/S0731-7085(03)00194-8 .
Marinković, Valentina D., Agbaba, Danica, Karjikovic-Rajic, K, Vladimirov, Sote, Nedeljković, Jovan, "Photochemical degradation of solid-state nisoldipine monitored by HPLC" in Journal of Pharmaceutical and Biomedical Analysis, 32, no. 4-5 (2003):929-935, https://doi.org/10.1016/S0731-7085(03)00194-8 . .