Exercise Decreases Susceptibility to Homocysteine Seizures: the Role of Oxidative Stress
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Hrnčić, DraganRašić-Marković, Aleksandra
Lekovic, J.
Krstić, Danijela Z.
Čolović, Mirjana B.
Macut, D.
Šušić, Veselinka
Đurić, Dragan M.
Stanojlović, Olivera
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The aim of the study was to examine the effects of chronic exercise training on seizures induced by homocysteine thiolactone (HCT) in adult rats. Rats were assigned to: sedentary control; exercise control; sedentary +HCT; exercise + HCT group. Animals in the exercise groups ran 30 min daily on a treadmill for 30 consecutive days (belt speed 20 m/min), while sedentary rats spent the same time on the treadmill (speed 0 m/min). On the 31st day, the HCT groups received HCT (8.0 mmol/kg), while the control groups received vehicle. Afterwards, convulsive behavior and EEG activity were registered. Lipid peroxidation, superoxide dismutase (SOD) and catalase (CAT) activity were ascertained in the rat hippocampus. No signs of seizures were registered in sedentary and exercise control rats. Seizure latency was increased, while number of seizure episodes and spike-and-wave discharges (SWD) in EEG were decreased in the exercise + HCT compared to the sedentary +HCT group. Seizure incidence, the seve...rity thereof and duration of SWDs were not significantly different between these groups. Exercise partly prevented increase of lipid peroxidation and decrease of the SOD and CAT activity after HCT administration. These results indicate beneficial effects of exercise in model of HCT induced seizures in rats, what could be, at least in part, a consequence of improved antioxidant enzymes activity.
Keywords:
physical activity / seizure behavior / homocysteine thiolactone / EEG / ratsSource:
International Journal of Sports Medicine, 2014, 35, 7, 544-550Funding / projects:
- The development of animal models of epilepsy and testing convulsive and anticonvulsive substances (RS-MESTD-Basic Research (BR or ON)-175032)
DOI: 10.1055/s-0033-1357162
ISSN: 0172-4622; 1439-3964
PubMed: 24227119
WoS: 000337946600002
Scopus: 2-s2.0-84903267326
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VinčaTY - JOUR AU - Hrnčić, Dragan AU - Rašić-Marković, Aleksandra AU - Lekovic, J. AU - Krstić, Danijela Z. AU - Čolović, Mirjana B. AU - Macut, D. AU - Šušić, Veselinka AU - Đurić, Dragan M. AU - Stanojlović, Olivera PY - 2014 UR - https://vinar.vin.bg.ac.rs/handle/123456789/6049 AB - The aim of the study was to examine the effects of chronic exercise training on seizures induced by homocysteine thiolactone (HCT) in adult rats. Rats were assigned to: sedentary control; exercise control; sedentary +HCT; exercise + HCT group. Animals in the exercise groups ran 30 min daily on a treadmill for 30 consecutive days (belt speed 20 m/min), while sedentary rats spent the same time on the treadmill (speed 0 m/min). On the 31st day, the HCT groups received HCT (8.0 mmol/kg), while the control groups received vehicle. Afterwards, convulsive behavior and EEG activity were registered. Lipid peroxidation, superoxide dismutase (SOD) and catalase (CAT) activity were ascertained in the rat hippocampus. No signs of seizures were registered in sedentary and exercise control rats. Seizure latency was increased, while number of seizure episodes and spike-and-wave discharges (SWD) in EEG were decreased in the exercise + HCT compared to the sedentary +HCT group. Seizure incidence, the severity thereof and duration of SWDs were not significantly different between these groups. Exercise partly prevented increase of lipid peroxidation and decrease of the SOD and CAT activity after HCT administration. These results indicate beneficial effects of exercise in model of HCT induced seizures in rats, what could be, at least in part, a consequence of improved antioxidant enzymes activity. T2 - International Journal of Sports Medicine T1 - Exercise Decreases Susceptibility to Homocysteine Seizures: the Role of Oxidative Stress VL - 35 IS - 7 SP - 544 EP - 550 DO - 10.1055/s-0033-1357162 ER -
@article{ author = "Hrnčić, Dragan and Rašić-Marković, Aleksandra and Lekovic, J. and Krstić, Danijela Z. and Čolović, Mirjana B. and Macut, D. and Šušić, Veselinka and Đurić, Dragan M. and Stanojlović, Olivera", year = "2014", abstract = "The aim of the study was to examine the effects of chronic exercise training on seizures induced by homocysteine thiolactone (HCT) in adult rats. Rats were assigned to: sedentary control; exercise control; sedentary +HCT; exercise + HCT group. Animals in the exercise groups ran 30 min daily on a treadmill for 30 consecutive days (belt speed 20 m/min), while sedentary rats spent the same time on the treadmill (speed 0 m/min). On the 31st day, the HCT groups received HCT (8.0 mmol/kg), while the control groups received vehicle. Afterwards, convulsive behavior and EEG activity were registered. Lipid peroxidation, superoxide dismutase (SOD) and catalase (CAT) activity were ascertained in the rat hippocampus. No signs of seizures were registered in sedentary and exercise control rats. Seizure latency was increased, while number of seizure episodes and spike-and-wave discharges (SWD) in EEG were decreased in the exercise + HCT compared to the sedentary +HCT group. Seizure incidence, the severity thereof and duration of SWDs were not significantly different between these groups. Exercise partly prevented increase of lipid peroxidation and decrease of the SOD and CAT activity after HCT administration. These results indicate beneficial effects of exercise in model of HCT induced seizures in rats, what could be, at least in part, a consequence of improved antioxidant enzymes activity.", journal = "International Journal of Sports Medicine", title = "Exercise Decreases Susceptibility to Homocysteine Seizures: the Role of Oxidative Stress", volume = "35", number = "7", pages = "544-550", doi = "10.1055/s-0033-1357162" }
Hrnčić, D., Rašić-Marković, A., Lekovic, J., Krstić, D. Z., Čolović, M. B., Macut, D., Šušić, V., Đurić, D. M.,& Stanojlović, O.. (2014). Exercise Decreases Susceptibility to Homocysteine Seizures: the Role of Oxidative Stress. in International Journal of Sports Medicine, 35(7), 544-550. https://doi.org/10.1055/s-0033-1357162
Hrnčić D, Rašić-Marković A, Lekovic J, Krstić DZ, Čolović MB, Macut D, Šušić V, Đurić DM, Stanojlović O. Exercise Decreases Susceptibility to Homocysteine Seizures: the Role of Oxidative Stress. in International Journal of Sports Medicine. 2014;35(7):544-550. doi:10.1055/s-0033-1357162 .
Hrnčić, Dragan, Rašić-Marković, Aleksandra, Lekovic, J., Krstić, Danijela Z., Čolović, Mirjana B., Macut, D., Šušić, Veselinka, Đurić, Dragan M., Stanojlović, Olivera, "Exercise Decreases Susceptibility to Homocysteine Seizures: the Role of Oxidative Stress" in International Journal of Sports Medicine, 35, no. 7 (2014):544-550, https://doi.org/10.1055/s-0033-1357162 . .