Relationship between mid-trimester ultrasound fetal liver length measurements and gestational diabetes mellitus
Authors
Perović, MilanGojnic, Miroslava
Arsić, Biljana
Pantic, Igor
Stefanovic, Tomislav
Kovacevic, Gordana
Kovacevic, Milica
Garalejic, Eliana
Dugalic, Stefan
Radakovic, Jovana
Babic, Uros
Isenović, Esma R.
Article (Published version)
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BackgroundThe aim of the present study was to investigate the relationship between mid-trimester ultrasound fetal liver length (FLL) and gestational diabetes mellitus (GDM) in a high-risk population. MethodsA prospective study was performed in 331 women with singleton pregnancies who were at high risk of GDM and were undergoing a mid-trimester ultrasound examination. The ultrasound scan at 23 weeks gestation was followed by a 100-g oral glucose tolerance test (OGTT) at 24 weeks gestation. Correlations between FLL and OGTT results at different time points were tested. Receiver operating characteristic (ROC) analysis of FLL as a potential prognostic factor for GDM was also performed. ResultsIn GDM patients, there was a significant positive correlation (P LT 0.01) between FLL and OGTT glycemia immediately before and 60, 120, and 180min after glucose intake. Mean FLL in GDM was significantly higher than in healthy subjects (41.04 vs 31.09mm, respectively; P LT 0.001). When tested as a pote...ntial prognostic factor for GDM, fetal liver measurements showed excellent diagnostic performance. The ROC analysis established a cut-off value of FLL of 39mm for the prediction GDM, with sensitivity of 71.76%, specificity 97.56%, positive predictive value 91.0%, and negative predictive value 90.9%. The usefulness of FLL measurements was supported by a high area under the ROC curve (90.5%). ConclusionIn conclusion, there is a strong correlation between FLL and OGTT results, with FLL possibly serving as a valid marker for the prediction of GDM in high-risk populations.
Keywords:
correlation / predictive value / sensitivity / specificity / ultrasonographySource:
Journal of Diabetes, 2015, 7, 4, 497-505Funding / projects:
- Insulin resistance: comparison of the role in onset and progression of type 2 diabetes, atherosclerotic vascular disease and neurodegenerative disorders (RS-MESTD-Basic Research (BR or ON)-175097)
- Light microscopy, electron microscopy, immunomorphologic, molecular biology and genetic investigations of malignant and nonmalignant renal diseases. (RS-MESTD-Basic Research (BR or ON)-175059)
- Hormonal regulation of expression and activity of the nitric oxide synthase and sodium-potassium pump in experimental models of insulin resistance, diabetes and cardiovascular disorders (RS-MESTD-Basic Research (BR or ON)-173033)
- Mediterranean Society for Metabolic Syndrome, Diabetes and Hypertension in Pregnancy [62013]
DOI: 10.1111/1753-0407.12207
ISSN: 1753-0393; 1753-0407
PubMed: 25124095
WoS: 000355862700010
Scopus: 2-s2.0-84930347001
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VinčaTY - JOUR AU - Perović, Milan AU - Gojnic, Miroslava AU - Arsić, Biljana AU - Pantic, Igor AU - Stefanovic, Tomislav AU - Kovacevic, Gordana AU - Kovacevic, Milica AU - Garalejic, Eliana AU - Dugalic, Stefan AU - Radakovic, Jovana AU - Babic, Uros AU - Isenović, Esma R. PY - 2015 UR - https://vinar.vin.bg.ac.rs/handle/123456789/603 AB - BackgroundThe aim of the present study was to investigate the relationship between mid-trimester ultrasound fetal liver length (FLL) and gestational diabetes mellitus (GDM) in a high-risk population. MethodsA prospective study was performed in 331 women with singleton pregnancies who were at high risk of GDM and were undergoing a mid-trimester ultrasound examination. The ultrasound scan at 23 weeks gestation was followed by a 100-g oral glucose tolerance test (OGTT) at 24 weeks gestation. Correlations between FLL and OGTT results at different time points were tested. Receiver operating characteristic (ROC) analysis of FLL as a potential prognostic factor for GDM was also performed. ResultsIn GDM patients, there was a significant positive correlation (P LT 0.01) between FLL and OGTT glycemia immediately before and 60, 120, and 180min after glucose intake. Mean FLL in GDM was significantly higher than in healthy subjects (41.04 vs 31.09mm, respectively; P LT 0.001). When tested as a potential prognostic factor for GDM, fetal liver measurements showed excellent diagnostic performance. The ROC analysis established a cut-off value of FLL of 39mm for the prediction GDM, with sensitivity of 71.76%, specificity 97.56%, positive predictive value 91.0%, and negative predictive value 90.9%. The usefulness of FLL measurements was supported by a high area under the ROC curve (90.5%). ConclusionIn conclusion, there is a strong correlation between FLL and OGTT results, with FLL possibly serving as a valid marker for the prediction of GDM in high-risk populations. T2 - Journal of Diabetes T1 - Relationship between mid-trimester ultrasound fetal liver length measurements and gestational diabetes mellitus VL - 7 IS - 4 SP - 497 EP - 505 DO - 10.1111/1753-0407.12207 ER -
@article{ author = "Perović, Milan and Gojnic, Miroslava and Arsić, Biljana and Pantic, Igor and Stefanovic, Tomislav and Kovacevic, Gordana and Kovacevic, Milica and Garalejic, Eliana and Dugalic, Stefan and Radakovic, Jovana and Babic, Uros and Isenović, Esma R.", year = "2015", abstract = "BackgroundThe aim of the present study was to investigate the relationship between mid-trimester ultrasound fetal liver length (FLL) and gestational diabetes mellitus (GDM) in a high-risk population. MethodsA prospective study was performed in 331 women with singleton pregnancies who were at high risk of GDM and were undergoing a mid-trimester ultrasound examination. The ultrasound scan at 23 weeks gestation was followed by a 100-g oral glucose tolerance test (OGTT) at 24 weeks gestation. Correlations between FLL and OGTT results at different time points were tested. Receiver operating characteristic (ROC) analysis of FLL as a potential prognostic factor for GDM was also performed. ResultsIn GDM patients, there was a significant positive correlation (P LT 0.01) between FLL and OGTT glycemia immediately before and 60, 120, and 180min after glucose intake. Mean FLL in GDM was significantly higher than in healthy subjects (41.04 vs 31.09mm, respectively; P LT 0.001). When tested as a potential prognostic factor for GDM, fetal liver measurements showed excellent diagnostic performance. The ROC analysis established a cut-off value of FLL of 39mm for the prediction GDM, with sensitivity of 71.76%, specificity 97.56%, positive predictive value 91.0%, and negative predictive value 90.9%. The usefulness of FLL measurements was supported by a high area under the ROC curve (90.5%). ConclusionIn conclusion, there is a strong correlation between FLL and OGTT results, with FLL possibly serving as a valid marker for the prediction of GDM in high-risk populations.", journal = "Journal of Diabetes", title = "Relationship between mid-trimester ultrasound fetal liver length measurements and gestational diabetes mellitus", volume = "7", number = "4", pages = "497-505", doi = "10.1111/1753-0407.12207" }
Perović, M., Gojnic, M., Arsić, B., Pantic, I., Stefanovic, T., Kovacevic, G., Kovacevic, M., Garalejic, E., Dugalic, S., Radakovic, J., Babic, U.,& Isenović, E. R.. (2015). Relationship between mid-trimester ultrasound fetal liver length measurements and gestational diabetes mellitus. in Journal of Diabetes, 7(4), 497-505. https://doi.org/10.1111/1753-0407.12207
Perović M, Gojnic M, Arsić B, Pantic I, Stefanovic T, Kovacevic G, Kovacevic M, Garalejic E, Dugalic S, Radakovic J, Babic U, Isenović ER. Relationship between mid-trimester ultrasound fetal liver length measurements and gestational diabetes mellitus. in Journal of Diabetes. 2015;7(4):497-505. doi:10.1111/1753-0407.12207 .
Perović, Milan, Gojnic, Miroslava, Arsić, Biljana, Pantic, Igor, Stefanovic, Tomislav, Kovacevic, Gordana, Kovacevic, Milica, Garalejic, Eliana, Dugalic, Stefan, Radakovic, Jovana, Babic, Uros, Isenović, Esma R., "Relationship between mid-trimester ultrasound fetal liver length measurements and gestational diabetes mellitus" in Journal of Diabetes, 7, no. 4 (2015):497-505, https://doi.org/10.1111/1753-0407.12207 . .