MMP-1 and-3 haplotype is associated with congenital anomalies of the kidney and urinary tract
Nema prikaza
Autori
Đurić, TamaraŽivković, Maja
Milosevic, Biljana
Anđelevski, Magdalena
Cvetković, Mirjana
Kostić, Mirjana M.
Stanković, Aleksandra
Članak u časopisu
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Congenital anomalies of the kidney and urinary tract (CAKUT) are a common cause of progressive chronic kidney disease that may lead to end-stage renal disease and renal replacement therapy in childhood. Altered expression or activity of matrix metalloproteinases (MMPs) have been found in CAKUT. The MMP-1, -3, and -8 polymorphisms studied here are located in the gene promoters and alter expression. Our aim was to investigate associations of MMP polymorphisms, solely and in haplotypes, with CAKUT in children. A case-control study with 101 pediatric patients and 281 controls was performed. The MMP-1 (-1607 1G/2G), -3 (5A/6A), and -8 (-799 C/T) genotypes were determined by PCR-restriction fragment length polymorphism. We found statistically significant associations of MMP-3 5A/6A polymorphism (p LT 0.0001) and 1G(-1607)-6A haplotype, with no preferences for MMP-8 -799C or T alleles, with CAKUT (OR = 2.93, 95 % CI 1.43-5.98, adjusted for gender, p = 0.003) and with obstructive uropathies in... a subgroup of patients (OR = 4.57, 95 % CI 2.74-7.61, adjusted for gender, p LT 0.0001). MMP-3 genotypes and MMP-3 and -1 haplotypes encompassing either MMP-8 -799C or T alleles were associated with CAKUT and obstructive uropathies in pediatric patients. Still, functional and association studies are needed to elucidate evident roles of MMPs in CAKUT.
Ključne reči:
CAKUT / Obstructive uropathy / Matrix metalloproteinase / Gene / PolymorphismsIzvor:
Pediatric Nephrology, 2014, 29, 5, 879-884Finansiranje / projekti:
- Genetska osnova humanih vaskularnih i inflamatornih bolesti (RS-MESTD-Basic Research (BR or ON)-175085)
DOI: 10.1007/s00467-013-2699-x
ISSN: 0931-041X; 1432-198X
PubMed: 24414606
WoS: 000334175400012
Scopus: 2-s2.0-84898890346
Kolekcije
Institucija/grupa
VinčaTY - JOUR AU - Đurić, Tamara AU - Živković, Maja AU - Milosevic, Biljana AU - Anđelevski, Magdalena AU - Cvetković, Mirjana AU - Kostić, Mirjana M. AU - Stanković, Aleksandra PY - 2014 UR - https://vinar.vin.bg.ac.rs/handle/123456789/5950 AB - Congenital anomalies of the kidney and urinary tract (CAKUT) are a common cause of progressive chronic kidney disease that may lead to end-stage renal disease and renal replacement therapy in childhood. Altered expression or activity of matrix metalloproteinases (MMPs) have been found in CAKUT. The MMP-1, -3, and -8 polymorphisms studied here are located in the gene promoters and alter expression. Our aim was to investigate associations of MMP polymorphisms, solely and in haplotypes, with CAKUT in children. A case-control study with 101 pediatric patients and 281 controls was performed. The MMP-1 (-1607 1G/2G), -3 (5A/6A), and -8 (-799 C/T) genotypes were determined by PCR-restriction fragment length polymorphism. We found statistically significant associations of MMP-3 5A/6A polymorphism (p LT 0.0001) and 1G(-1607)-6A haplotype, with no preferences for MMP-8 -799C or T alleles, with CAKUT (OR = 2.93, 95 % CI 1.43-5.98, adjusted for gender, p = 0.003) and with obstructive uropathies in a subgroup of patients (OR = 4.57, 95 % CI 2.74-7.61, adjusted for gender, p LT 0.0001). MMP-3 genotypes and MMP-3 and -1 haplotypes encompassing either MMP-8 -799C or T alleles were associated with CAKUT and obstructive uropathies in pediatric patients. Still, functional and association studies are needed to elucidate evident roles of MMPs in CAKUT. T2 - Pediatric Nephrology T1 - MMP-1 and-3 haplotype is associated with congenital anomalies of the kidney and urinary tract VL - 29 IS - 5 SP - 879 EP - 884 DO - 10.1007/s00467-013-2699-x ER -
@article{ author = "Đurić, Tamara and Živković, Maja and Milosevic, Biljana and Anđelevski, Magdalena and Cvetković, Mirjana and Kostić, Mirjana M. and Stanković, Aleksandra", year = "2014", abstract = "Congenital anomalies of the kidney and urinary tract (CAKUT) are a common cause of progressive chronic kidney disease that may lead to end-stage renal disease and renal replacement therapy in childhood. Altered expression or activity of matrix metalloproteinases (MMPs) have been found in CAKUT. The MMP-1, -3, and -8 polymorphisms studied here are located in the gene promoters and alter expression. Our aim was to investigate associations of MMP polymorphisms, solely and in haplotypes, with CAKUT in children. A case-control study with 101 pediatric patients and 281 controls was performed. The MMP-1 (-1607 1G/2G), -3 (5A/6A), and -8 (-799 C/T) genotypes were determined by PCR-restriction fragment length polymorphism. We found statistically significant associations of MMP-3 5A/6A polymorphism (p LT 0.0001) and 1G(-1607)-6A haplotype, with no preferences for MMP-8 -799C or T alleles, with CAKUT (OR = 2.93, 95 % CI 1.43-5.98, adjusted for gender, p = 0.003) and with obstructive uropathies in a subgroup of patients (OR = 4.57, 95 % CI 2.74-7.61, adjusted for gender, p LT 0.0001). MMP-3 genotypes and MMP-3 and -1 haplotypes encompassing either MMP-8 -799C or T alleles were associated with CAKUT and obstructive uropathies in pediatric patients. Still, functional and association studies are needed to elucidate evident roles of MMPs in CAKUT.", journal = "Pediatric Nephrology", title = "MMP-1 and-3 haplotype is associated with congenital anomalies of the kidney and urinary tract", volume = "29", number = "5", pages = "879-884", doi = "10.1007/s00467-013-2699-x" }
Đurić, T., Živković, M., Milosevic, B., Anđelevski, M., Cvetković, M., Kostić, M. M.,& Stanković, A.. (2014). MMP-1 and-3 haplotype is associated with congenital anomalies of the kidney and urinary tract. in Pediatric Nephrology, 29(5), 879-884. https://doi.org/10.1007/s00467-013-2699-x
Đurić T, Živković M, Milosevic B, Anđelevski M, Cvetković M, Kostić MM, Stanković A. MMP-1 and-3 haplotype is associated with congenital anomalies of the kidney and urinary tract. in Pediatric Nephrology. 2014;29(5):879-884. doi:10.1007/s00467-013-2699-x .
Đurić, Tamara, Živković, Maja, Milosevic, Biljana, Anđelevski, Magdalena, Cvetković, Mirjana, Kostić, Mirjana M., Stanković, Aleksandra, "MMP-1 and-3 haplotype is associated with congenital anomalies of the kidney and urinary tract" in Pediatric Nephrology, 29, no. 5 (2014):879-884, https://doi.org/10.1007/s00467-013-2699-x . .