Differential expression of tyrosine hydroxylase and transporters in the right and left stellate ganglion of socially isolated rats
Апстракт
Chronic isolation stress of adult rat males acted increasing gene expression of tyrosine hydroxylase (TH) and neuronal norepinephrine transporter (NET) in the right stellate ganglia, while vesicular monoamine transporter 2 (VMAT2) level remained unchanged. The stress decreased protein level of TH, as well as mRNA levels for NET and VMAT2 in the left stellate ganglia, but expressed no effect on protein levels of these two transporters. These results demonstrate asymmetry in noradrenegic genes in the right and left stellate ganglia during stress and provide molecular evidence to help explain the difference in response to the stress. (C) 2014 Elsevier B.V. All rights reserved.
Кључне речи:
Tyrosine hydroxylase / Norepinephrine transporter / Vesicular monoamine transporter 2 / Stellate ganglia / Chronic stressИзвор:
Autonomic Neuroscience: Basic and Clinical, 2014, 181, 85-89Финансирање / пројекти:
- Молекуларни механизми патофизиолошких промена у ћелијама централног нервног система и периферног ткива код сисара (RS-MESTD-Basic Research (BR or ON)-173044)
DOI: 10.1016/j.autneu.2014.01.002
ISSN: 1566-0702; 1872-7484
PubMed: 24480406
WoS: 000333785500012
Scopus: 2-s2.0-84893924313
Колекције
Институција/група
VinčaTY - JOUR AU - Jovanović, Predrag AU - Spasojević, Nataša AU - Stefanović, Bojana AU - Dronjak, Slađana PY - 2014 UR - https://vinar.vin.bg.ac.rs/handle/123456789/5941 AB - Chronic isolation stress of adult rat males acted increasing gene expression of tyrosine hydroxylase (TH) and neuronal norepinephrine transporter (NET) in the right stellate ganglia, while vesicular monoamine transporter 2 (VMAT2) level remained unchanged. The stress decreased protein level of TH, as well as mRNA levels for NET and VMAT2 in the left stellate ganglia, but expressed no effect on protein levels of these two transporters. These results demonstrate asymmetry in noradrenegic genes in the right and left stellate ganglia during stress and provide molecular evidence to help explain the difference in response to the stress. (C) 2014 Elsevier B.V. All rights reserved. T2 - Autonomic Neuroscience: Basic and Clinical T1 - Differential expression of tyrosine hydroxylase and transporters in the right and left stellate ganglion of socially isolated rats VL - 181 SP - 85 EP - 89 DO - 10.1016/j.autneu.2014.01.002 ER -
@article{ author = "Jovanović, Predrag and Spasojević, Nataša and Stefanović, Bojana and Dronjak, Slađana", year = "2014", abstract = "Chronic isolation stress of adult rat males acted increasing gene expression of tyrosine hydroxylase (TH) and neuronal norepinephrine transporter (NET) in the right stellate ganglia, while vesicular monoamine transporter 2 (VMAT2) level remained unchanged. The stress decreased protein level of TH, as well as mRNA levels for NET and VMAT2 in the left stellate ganglia, but expressed no effect on protein levels of these two transporters. These results demonstrate asymmetry in noradrenegic genes in the right and left stellate ganglia during stress and provide molecular evidence to help explain the difference in response to the stress. (C) 2014 Elsevier B.V. All rights reserved.", journal = "Autonomic Neuroscience: Basic and Clinical", title = "Differential expression of tyrosine hydroxylase and transporters in the right and left stellate ganglion of socially isolated rats", volume = "181", pages = "85-89", doi = "10.1016/j.autneu.2014.01.002" }
Jovanović, P., Spasojević, N., Stefanović, B.,& Dronjak, S.. (2014). Differential expression of tyrosine hydroxylase and transporters in the right and left stellate ganglion of socially isolated rats. in Autonomic Neuroscience: Basic and Clinical, 181, 85-89. https://doi.org/10.1016/j.autneu.2014.01.002
Jovanović P, Spasojević N, Stefanović B, Dronjak S. Differential expression of tyrosine hydroxylase and transporters in the right and left stellate ganglion of socially isolated rats. in Autonomic Neuroscience: Basic and Clinical. 2014;181:85-89. doi:10.1016/j.autneu.2014.01.002 .
Jovanović, Predrag, Spasojević, Nataša, Stefanović, Bojana, Dronjak, Slađana, "Differential expression of tyrosine hydroxylase and transporters in the right and left stellate ganglion of socially isolated rats" in Autonomic Neuroscience: Basic and Clinical, 181 (2014):85-89, https://doi.org/10.1016/j.autneu.2014.01.002 . .