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Increased survival after irradiation followed by regeneration of bone marrow stromal cells with a novel thiol-based radioprotector
dc.creator | Okić-Đorđević, Ivana | |
dc.creator | Trivanović, Drenka | |
dc.creator | Jovanović, Miloš | |
dc.creator | Ignjatović, Marija | |
dc.creator | Šećerov, Bojana Lj. | |
dc.creator | Mojovic, Milos | |
dc.creator | Bugarski, Diana | |
dc.creator | Bačić, Goran | |
dc.creator | Anđus, Pavle R. | |
dc.date.accessioned | 2018-03-02T00:03:38Z | |
dc.date.available | 2018-03-02T00:03:38Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 0353-9504 | |
dc.identifier.issn | 1332-8166 | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/5935 | |
dc.description.abstract | Aim To investigate the survival of laboratory rats after irradiation and to study the cellularity of their bone marrow and the multipotential mesenchymal stem cells (BM-MSCs) in groups treated with or without a new thiol-based radioprotector (GM2011) Methods Animals were irradiated by a Cobalt gamma source at 6.7 Gy. Treated animals were given i.p. GM2011 30 minutes before and 3 and 7 hours after irradiation. Controls consisted of sham irradiated animals without treatment and animals treated without irradiation. After 30 days post-irradiation, animals were sacrificed and bone marrow cells were prepared from isolated femurs. A colony forming unit-fibroblast (CFU-F) assay was performed to obtain the number of BM-MSCs. Results In the treated group, 87% of animals survived, compared to only 30% in the non-treated irradiated group. Irradiation induced significant changes in the bone marrow of the treated rats (total bone marrow cellularity was reduced by similar to 60% - from 63 to 28 cells x10(6)/femur and the frequency of the CFU-F per femur by similar to 70% - from 357 to 97), however GL2011 almost completely prevented the suppressive effect observed on day 30 post-irradiation (71 cells x 10(6)/femur and 230 CFU-F/femur). Conclusion Although the irradiation dosage was relatively high, GL2011 acted as a very effective new radioprotector. The recovery of the BN-MSCs and their counts support the effectiveness of the studied radioprotector. | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41005/RS// | |
dc.rights | openAccess | en |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Croatian Medical Journal | en |
dc.title | Increased survival after irradiation followed by regeneration of bone marrow stromal cells with a novel thiol-based radioprotector | en |
dc.type | article | en |
dc.rights.license | BY-NC-ND | |
dcterms.abstract | Aндјус, Павле Р.; Бациц, Горан; Бугарски, Диана; Игњатовиц, Марија; Јовановиц, Милос; Мојовиц, Милос; Шећеров Бојана Љ; Тривановиц, Дренка; Окиц-Дјордјевиц, Ивана; | |
dc.citation.volume | 55 | |
dc.citation.issue | 1 | |
dc.citation.spage | 45 | |
dc.citation.epage | 49 | |
dc.identifier.wos | 000333666400008 | |
dc.identifier.doi | 10.3325/cmj.2014.55.45 | |
dc.citation.rank | M22 | |
dc.identifier.pmid | 24577826 | |
dc.type.version | publishedVersion | |
dc.identifier.scopus | 2-s2.0-84895791458 | |
dc.identifier.fulltext | https://vinar.vin.bg.ac.rs//bitstream/id/6308/CroatMedJ_55_0045.pdf |