Response Factors to Pegylated Interferon-Alfa/Ribavirin Treatment in Chronic Hepatitis C Patients Genotype 1b
2014
Authors
Jovanović-Ćupić, Snežana P.Glišić, Sanja
Stanojevic, M.
Vasiljević, N.
Bojić, Tijana
Božović, Ana M.
Dimitrijević, Bogomir B.
Article
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Hepatitis C virus infection is the most common chronic blood-borne infection and one of the most important causes of chronic liver disease. Knowing the predictors associated with pegylated interferon/ribavirin (PEG-IFN/RBV) combination therapy response is important for evidence-based treatment recommendations. The goal of this study was to identify host and viral factors of response to PEG-IFN/RBV treatment in chronic hepatitis C genotype 1b patients. We have examined the relationship between gender, age, level of alanine aminotransferase (ALT), viral load and liver fibrosis progression on therapy response. ALT level and viral load were evaluated before starting treatment with combination therapy. The elevated levels of ALT and route of HCV transmission were found to be significantly associated with the response to therapy in HCV-infected patients. Our findings may be useful for estimating a patients likelihood Of achieving sustained viral response.
Keywords:
Hepatitis C virus (HCV) / genotype 1b / (pegylated) interferon-alfa/ribavirin and response to therapySource:
Archives of Biological Sciences, 2014, 66, 1, 193-201Funding / projects:
- Molecular determinants for tumor marker design (RS-MESTD-Basic Research (BR or ON)-173049)
- Research and verification of the multidisciplinary forensic methods in (RS-MESTD-Technological Development (TD or TR)-37021)
DOI: 10.2298/ABS1401193J
ISSN: 0354-4664; 1821-4339
WoS: 000330552400027
Scopus: 2-s2.0-84892428705
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VinčaTY - JOUR AU - Jovanović-Ćupić, Snežana P. AU - Glišić, Sanja AU - Stanojevic, M. AU - Vasiljević, N. AU - Bojić, Tijana AU - Božović, Ana M. AU - Dimitrijević, Bogomir B. PY - 2014 UR - https://vinar.vin.bg.ac.rs/handle/123456789/5858 AB - Hepatitis C virus infection is the most common chronic blood-borne infection and one of the most important causes of chronic liver disease. Knowing the predictors associated with pegylated interferon/ribavirin (PEG-IFN/RBV) combination therapy response is important for evidence-based treatment recommendations. The goal of this study was to identify host and viral factors of response to PEG-IFN/RBV treatment in chronic hepatitis C genotype 1b patients. We have examined the relationship between gender, age, level of alanine aminotransferase (ALT), viral load and liver fibrosis progression on therapy response. ALT level and viral load were evaluated before starting treatment with combination therapy. The elevated levels of ALT and route of HCV transmission were found to be significantly associated with the response to therapy in HCV-infected patients. Our findings may be useful for estimating a patients likelihood Of achieving sustained viral response. T2 - Archives of Biological Sciences T1 - Response Factors to Pegylated Interferon-Alfa/Ribavirin Treatment in Chronic Hepatitis C Patients Genotype 1b VL - 66 IS - 1 SP - 193 EP - 201 DO - 10.2298/ABS1401193J ER -
@article{ author = "Jovanović-Ćupić, Snežana P. and Glišić, Sanja and Stanojevic, M. and Vasiljević, N. and Bojić, Tijana and Božović, Ana M. and Dimitrijević, Bogomir B.", year = "2014", abstract = "Hepatitis C virus infection is the most common chronic blood-borne infection and one of the most important causes of chronic liver disease. Knowing the predictors associated with pegylated interferon/ribavirin (PEG-IFN/RBV) combination therapy response is important for evidence-based treatment recommendations. The goal of this study was to identify host and viral factors of response to PEG-IFN/RBV treatment in chronic hepatitis C genotype 1b patients. We have examined the relationship between gender, age, level of alanine aminotransferase (ALT), viral load and liver fibrosis progression on therapy response. ALT level and viral load were evaluated before starting treatment with combination therapy. The elevated levels of ALT and route of HCV transmission were found to be significantly associated with the response to therapy in HCV-infected patients. Our findings may be useful for estimating a patients likelihood Of achieving sustained viral response.", journal = "Archives of Biological Sciences", title = "Response Factors to Pegylated Interferon-Alfa/Ribavirin Treatment in Chronic Hepatitis C Patients Genotype 1b", volume = "66", number = "1", pages = "193-201", doi = "10.2298/ABS1401193J" }
Jovanović-Ćupić, S. P., Glišić, S., Stanojevic, M., Vasiljević, N., Bojić, T., Božović, A. M.,& Dimitrijević, B. B.. (2014). Response Factors to Pegylated Interferon-Alfa/Ribavirin Treatment in Chronic Hepatitis C Patients Genotype 1b. in Archives of Biological Sciences, 66(1), 193-201. https://doi.org/10.2298/ABS1401193J
Jovanović-Ćupić SP, Glišić S, Stanojevic M, Vasiljević N, Bojić T, Božović AM, Dimitrijević BB. Response Factors to Pegylated Interferon-Alfa/Ribavirin Treatment in Chronic Hepatitis C Patients Genotype 1b. in Archives of Biological Sciences. 2014;66(1):193-201. doi:10.2298/ABS1401193J .
Jovanović-Ćupić, Snežana P., Glišić, Sanja, Stanojevic, M., Vasiljević, N., Bojić, Tijana, Božović, Ana M., Dimitrijević, Bogomir B., "Response Factors to Pegylated Interferon-Alfa/Ribavirin Treatment in Chronic Hepatitis C Patients Genotype 1b" in Archives of Biological Sciences, 66, no. 1 (2014):193-201, https://doi.org/10.2298/ABS1401193J . .