The Antiradical, Anti-Inflammatory and Anti-Genotoxic Potential of Herbal Preparation Chlamyfin
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Autori
Leskovac, AndrejaJoksić, Gordana
Pašti, Igor A.
Lazarević-Pašti, Tamara
Nastasijević, Branislav J.
Petrović, Sandra
Članak u časopisu
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Herbal preparation Chlamyfin was investigated for its total polyphenol content, 2,2-diphenyl-1picrylhydrazyl (DPPH) scavenging activity, and anti-inflammatory and genotoxic properties. A high total polyphenol content provided evidence of high DPPH radical scavenging activity (IC50 = 4.96 +/- 0.23 mu g/ml). Analysis of the electrochemical behavior of Chlamyfin indicated high reducing ability, i.e., high antioxidant capacity, in agreement with the DPPH test. Analysis of myeloperoxidase (MPO) inhibition by Chlamyfin suggested anti-inflammatory action (IC50 values of 5.40 mu g/ml and 4.45 i_tg/m1 for an incubation time of 10 and 30 min, respectively). For genotoxic assessment, oxidative stress was induced by irradiation of peripheral whole blood with gamma-radiation in vitro. In the presence of Chlamyfin, reduced incidence of micronuclei without disturbance to the proliferative potential of cells was evidenced in both irradiated and unirradiated samples, indicating its genoprotective prope...rties. It was shown that Chlamyfm, in addition to its bactericidal effect, also possesses strong antioxidant, anti-inflammatory and anti-genotoxic properties.
Ključne reči:
Chlamyfin / polyphenol / antiradical effects / anti-inflammatory potential / anti-genotoxic potentialIzvor:
Macedonian Journal of Chemistry and Chemical Engineering, 2013, 32, 2, 227-237Finansiranje / projekti:
- Radiosenzitivnost humanog genoma (RS-MESTD-Basic Research (BR or ON)-173046)
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Institucija/grupa
VinčaTY - JOUR AU - Leskovac, Andreja AU - Joksić, Gordana AU - Pašti, Igor A. AU - Lazarević-Pašti, Tamara AU - Nastasijević, Branislav J. AU - Petrović, Sandra PY - 2013 UR - https://vinar.vin.bg.ac.rs/handle/123456789/5830 AB - Herbal preparation Chlamyfin was investigated for its total polyphenol content, 2,2-diphenyl-1picrylhydrazyl (DPPH) scavenging activity, and anti-inflammatory and genotoxic properties. A high total polyphenol content provided evidence of high DPPH radical scavenging activity (IC50 = 4.96 +/- 0.23 mu g/ml). Analysis of the electrochemical behavior of Chlamyfin indicated high reducing ability, i.e., high antioxidant capacity, in agreement with the DPPH test. Analysis of myeloperoxidase (MPO) inhibition by Chlamyfin suggested anti-inflammatory action (IC50 values of 5.40 mu g/ml and 4.45 i_tg/m1 for an incubation time of 10 and 30 min, respectively). For genotoxic assessment, oxidative stress was induced by irradiation of peripheral whole blood with gamma-radiation in vitro. In the presence of Chlamyfin, reduced incidence of micronuclei without disturbance to the proliferative potential of cells was evidenced in both irradiated and unirradiated samples, indicating its genoprotective properties. It was shown that Chlamyfm, in addition to its bactericidal effect, also possesses strong antioxidant, anti-inflammatory and anti-genotoxic properties. T2 - Macedonian Journal of Chemistry and Chemical Engineering T1 - The Antiradical, Anti-Inflammatory and Anti-Genotoxic Potential of Herbal Preparation Chlamyfin VL - 32 IS - 2 SP - 227 EP - 237 UR - https://hdl.handle.net/21.15107/rcub_vinar_5830 ER -
@article{ author = "Leskovac, Andreja and Joksić, Gordana and Pašti, Igor A. and Lazarević-Pašti, Tamara and Nastasijević, Branislav J. and Petrović, Sandra", year = "2013", abstract = "Herbal preparation Chlamyfin was investigated for its total polyphenol content, 2,2-diphenyl-1picrylhydrazyl (DPPH) scavenging activity, and anti-inflammatory and genotoxic properties. A high total polyphenol content provided evidence of high DPPH radical scavenging activity (IC50 = 4.96 +/- 0.23 mu g/ml). Analysis of the electrochemical behavior of Chlamyfin indicated high reducing ability, i.e., high antioxidant capacity, in agreement with the DPPH test. Analysis of myeloperoxidase (MPO) inhibition by Chlamyfin suggested anti-inflammatory action (IC50 values of 5.40 mu g/ml and 4.45 i_tg/m1 for an incubation time of 10 and 30 min, respectively). For genotoxic assessment, oxidative stress was induced by irradiation of peripheral whole blood with gamma-radiation in vitro. In the presence of Chlamyfin, reduced incidence of micronuclei without disturbance to the proliferative potential of cells was evidenced in both irradiated and unirradiated samples, indicating its genoprotective properties. It was shown that Chlamyfm, in addition to its bactericidal effect, also possesses strong antioxidant, anti-inflammatory and anti-genotoxic properties.", journal = "Macedonian Journal of Chemistry and Chemical Engineering", title = "The Antiradical, Anti-Inflammatory and Anti-Genotoxic Potential of Herbal Preparation Chlamyfin", volume = "32", number = "2", pages = "227-237", url = "https://hdl.handle.net/21.15107/rcub_vinar_5830" }
Leskovac, A., Joksić, G., Pašti, I. A., Lazarević-Pašti, T., Nastasijević, B. J.,& Petrović, S.. (2013). The Antiradical, Anti-Inflammatory and Anti-Genotoxic Potential of Herbal Preparation Chlamyfin. in Macedonian Journal of Chemistry and Chemical Engineering, 32(2), 227-237. https://hdl.handle.net/21.15107/rcub_vinar_5830
Leskovac A, Joksić G, Pašti IA, Lazarević-Pašti T, Nastasijević BJ, Petrović S. The Antiradical, Anti-Inflammatory and Anti-Genotoxic Potential of Herbal Preparation Chlamyfin. in Macedonian Journal of Chemistry and Chemical Engineering. 2013;32(2):227-237. https://hdl.handle.net/21.15107/rcub_vinar_5830 .
Leskovac, Andreja, Joksić, Gordana, Pašti, Igor A., Lazarević-Pašti, Tamara, Nastasijević, Branislav J., Petrović, Sandra, "The Antiradical, Anti-Inflammatory and Anti-Genotoxic Potential of Herbal Preparation Chlamyfin" in Macedonian Journal of Chemistry and Chemical Engineering, 32, no. 2 (2013):227-237, https://hdl.handle.net/21.15107/rcub_vinar_5830 .