Synthesis of fluorine substituted hydroxyapatite nanopowders and application of the central composite design for determination of its antimicrobial effects
Нема приказа
Аутори
Stanić, VojislavDimitrijević, Suzana I.
Antonović, Dušan
Jokić, Bojan M.
Zec, Slavica
Tanaskovic, Sladjana T.
Raičević, Slavica
Чланак у часопису
Метаподаци
Приказ свих података о документуАпстракт
Synthetic biomaterials based on fluorine substituted hydroxyapatite are potentially attractive for orthopedic and dental implant applications. The new synthesis of fluorine substituted hydroxyapatite samples were done by neutralization, which consists of adding the solution of HF and H3PO4 in suspension of Ca(OH)(2). Characterization studies from XRD, SEM and FTIR spectra showed that crystals are obtained with apatite structure and those particles of all samples are nano size, with an average length of 80 nm and about 15-25 nm in diameter. The central composite design was used in order to determine the optimal conditions for the antimicrobial activity of the synthesized samples. In order to evaluate the influence of operating parameters on the percent of viable cell reduction of Streptococcus mutans, three independent variables were chosen: exposure time, pH of saline and floride concentration in apatite samples. The experimental and predicted antimicrobial activities were in close agr...eement. Antimicrobial activity of the samples increases with the increase of fluoride concentration and the decreased pH of saline. The maximum antimicrobial activity was achieved at the initial pH of 4. (C) 2013 Elsevier B.V. All rights reserved.
Кључне речи:
Fluoroapatite / Biomaterials / Antimicrobial / Streptococcus mutans / CariessИзвор:
Applied Surface Science, 2014, 290, 346-352Финансирање / пројекти:
- Нове технологије за мониторинг и заштиту животног окружења од штетних хемијских супстанци и радијационог оптерећења (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-43009)
- Примена биотехнолошких метода у одрживом искоришћењу нус-производа агроиндустрије (RS-MESTD-Technological Development (TD or TR)-31035)
DOI: 10.1016/j.apsusc.2013.11.081
ISSN: 0169-4332; 1873-5584
WoS: 000329060100052
Scopus: 2-s2.0-84891028891
Колекције
Институција/група
VinčaTY - JOUR AU - Stanić, Vojislav AU - Dimitrijević, Suzana I. AU - Antonović, Dušan AU - Jokić, Bojan M. AU - Zec, Slavica AU - Tanaskovic, Sladjana T. AU - Raičević, Slavica PY - 2014 UR - https://vinar.vin.bg.ac.rs/handle/123456789/5820 AB - Synthetic biomaterials based on fluorine substituted hydroxyapatite are potentially attractive for orthopedic and dental implant applications. The new synthesis of fluorine substituted hydroxyapatite samples were done by neutralization, which consists of adding the solution of HF and H3PO4 in suspension of Ca(OH)(2). Characterization studies from XRD, SEM and FTIR spectra showed that crystals are obtained with apatite structure and those particles of all samples are nano size, with an average length of 80 nm and about 15-25 nm in diameter. The central composite design was used in order to determine the optimal conditions for the antimicrobial activity of the synthesized samples. In order to evaluate the influence of operating parameters on the percent of viable cell reduction of Streptococcus mutans, three independent variables were chosen: exposure time, pH of saline and floride concentration in apatite samples. The experimental and predicted antimicrobial activities were in close agreement. Antimicrobial activity of the samples increases with the increase of fluoride concentration and the decreased pH of saline. The maximum antimicrobial activity was achieved at the initial pH of 4. (C) 2013 Elsevier B.V. All rights reserved. T2 - Applied Surface Science T1 - Synthesis of fluorine substituted hydroxyapatite nanopowders and application of the central composite design for determination of its antimicrobial effects VL - 290 SP - 346 EP - 352 DO - 10.1016/j.apsusc.2013.11.081 ER -
@article{ author = "Stanić, Vojislav and Dimitrijević, Suzana I. and Antonović, Dušan and Jokić, Bojan M. and Zec, Slavica and Tanaskovic, Sladjana T. and Raičević, Slavica", year = "2014", abstract = "Synthetic biomaterials based on fluorine substituted hydroxyapatite are potentially attractive for orthopedic and dental implant applications. The new synthesis of fluorine substituted hydroxyapatite samples were done by neutralization, which consists of adding the solution of HF and H3PO4 in suspension of Ca(OH)(2). Characterization studies from XRD, SEM and FTIR spectra showed that crystals are obtained with apatite structure and those particles of all samples are nano size, with an average length of 80 nm and about 15-25 nm in diameter. The central composite design was used in order to determine the optimal conditions for the antimicrobial activity of the synthesized samples. In order to evaluate the influence of operating parameters on the percent of viable cell reduction of Streptococcus mutans, three independent variables were chosen: exposure time, pH of saline and floride concentration in apatite samples. The experimental and predicted antimicrobial activities were in close agreement. Antimicrobial activity of the samples increases with the increase of fluoride concentration and the decreased pH of saline. The maximum antimicrobial activity was achieved at the initial pH of 4. (C) 2013 Elsevier B.V. All rights reserved.", journal = "Applied Surface Science", title = "Synthesis of fluorine substituted hydroxyapatite nanopowders and application of the central composite design for determination of its antimicrobial effects", volume = "290", pages = "346-352", doi = "10.1016/j.apsusc.2013.11.081" }
Stanić, V., Dimitrijević, S. I., Antonović, D., Jokić, B. M., Zec, S., Tanaskovic, S. T.,& Raičević, S.. (2014). Synthesis of fluorine substituted hydroxyapatite nanopowders and application of the central composite design for determination of its antimicrobial effects. in Applied Surface Science, 290, 346-352. https://doi.org/10.1016/j.apsusc.2013.11.081
Stanić V, Dimitrijević SI, Antonović D, Jokić BM, Zec S, Tanaskovic ST, Raičević S. Synthesis of fluorine substituted hydroxyapatite nanopowders and application of the central composite design for determination of its antimicrobial effects. in Applied Surface Science. 2014;290:346-352. doi:10.1016/j.apsusc.2013.11.081 .
Stanić, Vojislav, Dimitrijević, Suzana I., Antonović, Dušan, Jokić, Bojan M., Zec, Slavica, Tanaskovic, Sladjana T., Raičević, Slavica, "Synthesis of fluorine substituted hydroxyapatite nanopowders and application of the central composite design for determination of its antimicrobial effects" in Applied Surface Science, 290 (2014):346-352, https://doi.org/10.1016/j.apsusc.2013.11.081 . .