The glutathione S-transferase T1 deletion is associated with susceptibility to multiple sclerosis
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Živković, MajaŽivotić, Ivan
Dinčić, Evica
Stojković, Ljiljana S.
Vojinovic, Slobodan
Stanković, Aleksandra
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Background: Multiple sclerosis (MS) occurs as a result of interaction between genetic and environmental factors. Recent data support the view that oxidative damage is one of an early event in MS tissue injury. The safe elimination of reactive oxygen species and toxins via glutathione S-transferase (GST) pathways is required in order to protect cells against reactive oxygen-induced damage. The aim of our study was to analyze the possible association of GSTM1 and GSTT1 gene polymorphisms with the susceptibility and clinical parameters of MS, in 455 consecutive patients and 366 controls. Methods: A multiplex polymerase chain reaction (PCR) was used to detect the deletions in GSTM1 and GSTT1 genes. Results: Patients with MS had significantly higher frequency of GSTT1 null genotype compared to controls (37.36% vs. 21.86%, respectively, p LT 0.0001, adjusted OR 2.13 (1.56-2.90)), as well as double deletions (15.38% vs. 10.38%, respectively, p LT 0.05). The carriers of GSTM1 deletion had sign...ificantly earlier onset of MS compared to the wild-type carriers (28.31 +/- 8.45 vs. 30.64 +/- 9.30 years, respectively, p = 0.03). Conclusion: This study suggests the potential pathogenic role of GSTT1 deletion on MS susceptibility. There are no similar data published so far, yet this study should be replicated in other populations. (C) 2013 Elsevier B.V. All rights reserved.
Keywords:
Glutathione S-transferase T1 / Glutathione S-transferase M1 / Antioxidant defense / Gene polymorphism / Deletion / Multiple sclerosisSource:
Journal of the Neurological Sciences, 2013, 334, 1-2, 6-9Funding / projects:
- Genetic basis of human vascular and inflammatory diseases (RS-MESTD-Basic Research (BR or ON)-175085)
DOI: 10.1016/j.jns.2013.07.001
ISSN: 0022-510X; 1878-5883
PubMed: 23932298
WoS: 000327674800002
Scopus: 2-s2.0-84887493190
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VinčaTY - JOUR AU - Živković, Maja AU - Životić, Ivan AU - Dinčić, Evica AU - Stojković, Ljiljana S. AU - Vojinovic, Slobodan AU - Stanković, Aleksandra PY - 2013 UR - https://vinar.vin.bg.ac.rs/handle/123456789/5771 AB - Background: Multiple sclerosis (MS) occurs as a result of interaction between genetic and environmental factors. Recent data support the view that oxidative damage is one of an early event in MS tissue injury. The safe elimination of reactive oxygen species and toxins via glutathione S-transferase (GST) pathways is required in order to protect cells against reactive oxygen-induced damage. The aim of our study was to analyze the possible association of GSTM1 and GSTT1 gene polymorphisms with the susceptibility and clinical parameters of MS, in 455 consecutive patients and 366 controls. Methods: A multiplex polymerase chain reaction (PCR) was used to detect the deletions in GSTM1 and GSTT1 genes. Results: Patients with MS had significantly higher frequency of GSTT1 null genotype compared to controls (37.36% vs. 21.86%, respectively, p LT 0.0001, adjusted OR 2.13 (1.56-2.90)), as well as double deletions (15.38% vs. 10.38%, respectively, p LT 0.05). The carriers of GSTM1 deletion had significantly earlier onset of MS compared to the wild-type carriers (28.31 +/- 8.45 vs. 30.64 +/- 9.30 years, respectively, p = 0.03). Conclusion: This study suggests the potential pathogenic role of GSTT1 deletion on MS susceptibility. There are no similar data published so far, yet this study should be replicated in other populations. (C) 2013 Elsevier B.V. All rights reserved. T2 - Journal of the Neurological Sciences T1 - The glutathione S-transferase T1 deletion is associated with susceptibility to multiple sclerosis VL - 334 IS - 1-2 SP - 6 EP - 9 DO - 10.1016/j.jns.2013.07.001 ER -
@article{ author = "Živković, Maja and Životić, Ivan and Dinčić, Evica and Stojković, Ljiljana S. and Vojinovic, Slobodan and Stanković, Aleksandra", year = "2013", abstract = "Background: Multiple sclerosis (MS) occurs as a result of interaction between genetic and environmental factors. Recent data support the view that oxidative damage is one of an early event in MS tissue injury. The safe elimination of reactive oxygen species and toxins via glutathione S-transferase (GST) pathways is required in order to protect cells against reactive oxygen-induced damage. The aim of our study was to analyze the possible association of GSTM1 and GSTT1 gene polymorphisms with the susceptibility and clinical parameters of MS, in 455 consecutive patients and 366 controls. Methods: A multiplex polymerase chain reaction (PCR) was used to detect the deletions in GSTM1 and GSTT1 genes. Results: Patients with MS had significantly higher frequency of GSTT1 null genotype compared to controls (37.36% vs. 21.86%, respectively, p LT 0.0001, adjusted OR 2.13 (1.56-2.90)), as well as double deletions (15.38% vs. 10.38%, respectively, p LT 0.05). The carriers of GSTM1 deletion had significantly earlier onset of MS compared to the wild-type carriers (28.31 +/- 8.45 vs. 30.64 +/- 9.30 years, respectively, p = 0.03). Conclusion: This study suggests the potential pathogenic role of GSTT1 deletion on MS susceptibility. There are no similar data published so far, yet this study should be replicated in other populations. (C) 2013 Elsevier B.V. All rights reserved.", journal = "Journal of the Neurological Sciences", title = "The glutathione S-transferase T1 deletion is associated with susceptibility to multiple sclerosis", volume = "334", number = "1-2", pages = "6-9", doi = "10.1016/j.jns.2013.07.001" }
Živković, M., Životić, I., Dinčić, E., Stojković, L. S., Vojinovic, S.,& Stanković, A.. (2013). The glutathione S-transferase T1 deletion is associated with susceptibility to multiple sclerosis. in Journal of the Neurological Sciences, 334(1-2), 6-9. https://doi.org/10.1016/j.jns.2013.07.001
Živković M, Životić I, Dinčić E, Stojković LS, Vojinovic S, Stanković A. The glutathione S-transferase T1 deletion is associated with susceptibility to multiple sclerosis. in Journal of the Neurological Sciences. 2013;334(1-2):6-9. doi:10.1016/j.jns.2013.07.001 .
Živković, Maja, Životić, Ivan, Dinčić, Evica, Stojković, Ljiljana S., Vojinovic, Slobodan, Stanković, Aleksandra, "The glutathione S-transferase T1 deletion is associated with susceptibility to multiple sclerosis" in Journal of the Neurological Sciences, 334, no. 1-2 (2013):6-9, https://doi.org/10.1016/j.jns.2013.07.001 . .