Significance of p53-binding protein 1 (53BP1) expression in thyroid papillary microcarcinoma: association with BRAF(V600E) mutation status
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Аутори
Mussazhanova, ZhannaMatsuda, Katsuya
Naruke, Yuki
Mitsutake, Norisato
Stanojević, Boban
Rougounovitch, Tatiana
Saenko, Vladimir
Suzuki, Keiji
Nishihara, Eijyun
Hirokawa, Mitsuyoshi
Ito, Masahiro
Nakashima, Masahiro
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Метаподаци
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AimsIn a previous report, we proposed that analysis of 53BP1 expression by immunofluorescence could be a useful tool in estimating the level of genomic instability (GIN), as well as the malignant potential, of thyroid tumours. In an attempt to clarify the value of 53BP1 expression as a new molecular marker for the aggressiveness of thyroid papillary microcarcinoma (PMC), we assessed the association between the type of 53BP1 expression and clinicopathological features such as tumour size, extrathyroidal invasion, lymph node metastasis and BRAF(V600E) mutation of PMC. Methods and resultsA total of 36 surgically resected thyroid tumours, including 13 PMC and 23 conventional papillary thyroid carcinomas (PTC), were available for this study. Analysis using immunofluorescence revealed that the incidence of an abnormal or high DNA damage response (DDR) type of 53BP1 expression was significantly higher in PTC than PMC. BRAF(V600E) mutation was not associated significantly with tumour aggressiv...eness in either PMC or PTC cases. Abnormal/high DDR type of 53BP1 expression was associated closely with both BRAF(V600E) mutation and papillary and/or trabecular architecture of PMC. ConclusionsAbnormal/high DDR type of 53BP1 expression might be associated with GIN and papillary/trabecular morphology at an early stage of PTC carcinogenesis through BRAF(V600E) mutation.
Кључне речи:
53BP1 / BRAF / genomic instability / immunofluorescence / thyroid papillary microcarcinomaИзвор:
Histopathology, 2013, 63, 5, 726-734Финансирање / пројекти:
- Nagasaki University Global Center of Excellence (COE), Japanese Ministry of Education, Science, Sports and Culture [24590414]
DOI: 10.1111/his.12233
ISSN: 0309-0167; 1365-2559
PubMed: 24004175
WoS: 000325545600013
Scopus: 2-s2.0-84885432843
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Институција/група
VinčaTY - JOUR AU - Mussazhanova, Zhanna AU - Matsuda, Katsuya AU - Naruke, Yuki AU - Mitsutake, Norisato AU - Stanojević, Boban AU - Rougounovitch, Tatiana AU - Saenko, Vladimir AU - Suzuki, Keiji AU - Nishihara, Eijyun AU - Hirokawa, Mitsuyoshi AU - Ito, Masahiro AU - Nakashima, Masahiro PY - 2013 UR - https://vinar.vin.bg.ac.rs/handle/123456789/5717 AB - AimsIn a previous report, we proposed that analysis of 53BP1 expression by immunofluorescence could be a useful tool in estimating the level of genomic instability (GIN), as well as the malignant potential, of thyroid tumours. In an attempt to clarify the value of 53BP1 expression as a new molecular marker for the aggressiveness of thyroid papillary microcarcinoma (PMC), we assessed the association between the type of 53BP1 expression and clinicopathological features such as tumour size, extrathyroidal invasion, lymph node metastasis and BRAF(V600E) mutation of PMC. Methods and resultsA total of 36 surgically resected thyroid tumours, including 13 PMC and 23 conventional papillary thyroid carcinomas (PTC), were available for this study. Analysis using immunofluorescence revealed that the incidence of an abnormal or high DNA damage response (DDR) type of 53BP1 expression was significantly higher in PTC than PMC. BRAF(V600E) mutation was not associated significantly with tumour aggressiveness in either PMC or PTC cases. Abnormal/high DDR type of 53BP1 expression was associated closely with both BRAF(V600E) mutation and papillary and/or trabecular architecture of PMC. ConclusionsAbnormal/high DDR type of 53BP1 expression might be associated with GIN and papillary/trabecular morphology at an early stage of PTC carcinogenesis through BRAF(V600E) mutation. T2 - Histopathology T1 - Significance of p53-binding protein 1 (53BP1) expression in thyroid papillary microcarcinoma: association with BRAF(V600E) mutation status VL - 63 IS - 5 SP - 726 EP - 734 DO - 10.1111/his.12233 ER -
@article{ author = "Mussazhanova, Zhanna and Matsuda, Katsuya and Naruke, Yuki and Mitsutake, Norisato and Stanojević, Boban and Rougounovitch, Tatiana and Saenko, Vladimir and Suzuki, Keiji and Nishihara, Eijyun and Hirokawa, Mitsuyoshi and Ito, Masahiro and Nakashima, Masahiro", year = "2013", abstract = "AimsIn a previous report, we proposed that analysis of 53BP1 expression by immunofluorescence could be a useful tool in estimating the level of genomic instability (GIN), as well as the malignant potential, of thyroid tumours. In an attempt to clarify the value of 53BP1 expression as a new molecular marker for the aggressiveness of thyroid papillary microcarcinoma (PMC), we assessed the association between the type of 53BP1 expression and clinicopathological features such as tumour size, extrathyroidal invasion, lymph node metastasis and BRAF(V600E) mutation of PMC. Methods and resultsA total of 36 surgically resected thyroid tumours, including 13 PMC and 23 conventional papillary thyroid carcinomas (PTC), were available for this study. Analysis using immunofluorescence revealed that the incidence of an abnormal or high DNA damage response (DDR) type of 53BP1 expression was significantly higher in PTC than PMC. BRAF(V600E) mutation was not associated significantly with tumour aggressiveness in either PMC or PTC cases. Abnormal/high DDR type of 53BP1 expression was associated closely with both BRAF(V600E) mutation and papillary and/or trabecular architecture of PMC. ConclusionsAbnormal/high DDR type of 53BP1 expression might be associated with GIN and papillary/trabecular morphology at an early stage of PTC carcinogenesis through BRAF(V600E) mutation.", journal = "Histopathology", title = "Significance of p53-binding protein 1 (53BP1) expression in thyroid papillary microcarcinoma: association with BRAF(V600E) mutation status", volume = "63", number = "5", pages = "726-734", doi = "10.1111/his.12233" }
Mussazhanova, Z., Matsuda, K., Naruke, Y., Mitsutake, N., Stanojević, B., Rougounovitch, T., Saenko, V., Suzuki, K., Nishihara, E., Hirokawa, M., Ito, M.,& Nakashima, M.. (2013). Significance of p53-binding protein 1 (53BP1) expression in thyroid papillary microcarcinoma: association with BRAF(V600E) mutation status. in Histopathology, 63(5), 726-734. https://doi.org/10.1111/his.12233
Mussazhanova Z, Matsuda K, Naruke Y, Mitsutake N, Stanojević B, Rougounovitch T, Saenko V, Suzuki K, Nishihara E, Hirokawa M, Ito M, Nakashima M. Significance of p53-binding protein 1 (53BP1) expression in thyroid papillary microcarcinoma: association with BRAF(V600E) mutation status. in Histopathology. 2013;63(5):726-734. doi:10.1111/his.12233 .
Mussazhanova, Zhanna, Matsuda, Katsuya, Naruke, Yuki, Mitsutake, Norisato, Stanojević, Boban, Rougounovitch, Tatiana, Saenko, Vladimir, Suzuki, Keiji, Nishihara, Eijyun, Hirokawa, Mitsuyoshi, Ito, Masahiro, Nakashima, Masahiro, "Significance of p53-binding protein 1 (53BP1) expression in thyroid papillary microcarcinoma: association with BRAF(V600E) mutation status" in Histopathology, 63, no. 5 (2013):726-734, https://doi.org/10.1111/his.12233 . .