Hypothalamic noradrenaline synthesis, uptake and storage in rats during adaptation to long-term individual housing
Апстракт
The brain monoamine systems play a crucial role in mediating social behaviors. In order to assess the effect of socially isolated rats on neurochemical substrates in hypothalamus we measured levels of tyrosine hydroxylase (TH), noradrenaline transporter (NET) and vesicular monoamine transporter 2 (VMAT 2). Our results show that 12 weeks of social isolation produced no significant changes in noradrenaline content in hypothalamus. The levels of TH and NET were elevated in these animals, whereas level of VMAT 2 was unchanged. The data suggests that both enhanced synthesis and reuptake may aid in the recovery of noradrenaline content in the hypothalamus. The adaptation of the hypothalamic noradrenaline to long period of stress may have great physiological importance and may represent mechanism designed to help the organism adapt to the deleterious effects of chronic indiviual housing.
Кључне речи:
hypothalamus / noradrenaline / tyrosine hydroxylase / noradrenaline transporters / isolation stress / ratsИзвор:
Neurochemical Journal, 2013, 7, 2, 139-143Финансирање / пројекти:
- Молекуларни механизми патофизиолошких промена у ћелијама централног нервног система и периферног ткива код сисара (RS-MESTD-Basic Research (BR or ON)-173044)
DOI: 10.1134/S1819712413020050
ISSN: 1819-7124; 1819-7132
WoS: 000320338500008
Scopus: 2-s2.0-84878787997
Колекције
Институција/група
VinčaTY - JOUR AU - Spasojević, Nataša AU - Jovanović, Predrag AU - Stanisavljevic, D. AU - Stefanović, Bojana AU - Dronjak, Slađana PY - 2013 UR - https://vinar.vin.bg.ac.rs/handle/123456789/5546 AB - The brain monoamine systems play a crucial role in mediating social behaviors. In order to assess the effect of socially isolated rats on neurochemical substrates in hypothalamus we measured levels of tyrosine hydroxylase (TH), noradrenaline transporter (NET) and vesicular monoamine transporter 2 (VMAT 2). Our results show that 12 weeks of social isolation produced no significant changes in noradrenaline content in hypothalamus. The levels of TH and NET were elevated in these animals, whereas level of VMAT 2 was unchanged. The data suggests that both enhanced synthesis and reuptake may aid in the recovery of noradrenaline content in the hypothalamus. The adaptation of the hypothalamic noradrenaline to long period of stress may have great physiological importance and may represent mechanism designed to help the organism adapt to the deleterious effects of chronic indiviual housing. T2 - Neurochemical Journal T1 - Hypothalamic noradrenaline synthesis, uptake and storage in rats during adaptation to long-term individual housing VL - 7 IS - 2 SP - 139 EP - 143 DO - 10.1134/S1819712413020050 ER -
@article{ author = "Spasojević, Nataša and Jovanović, Predrag and Stanisavljevic, D. and Stefanović, Bojana and Dronjak, Slađana", year = "2013", abstract = "The brain monoamine systems play a crucial role in mediating social behaviors. In order to assess the effect of socially isolated rats on neurochemical substrates in hypothalamus we measured levels of tyrosine hydroxylase (TH), noradrenaline transporter (NET) and vesicular monoamine transporter 2 (VMAT 2). Our results show that 12 weeks of social isolation produced no significant changes in noradrenaline content in hypothalamus. The levels of TH and NET were elevated in these animals, whereas level of VMAT 2 was unchanged. The data suggests that both enhanced synthesis and reuptake may aid in the recovery of noradrenaline content in the hypothalamus. The adaptation of the hypothalamic noradrenaline to long period of stress may have great physiological importance and may represent mechanism designed to help the organism adapt to the deleterious effects of chronic indiviual housing.", journal = "Neurochemical Journal", title = "Hypothalamic noradrenaline synthesis, uptake and storage in rats during adaptation to long-term individual housing", volume = "7", number = "2", pages = "139-143", doi = "10.1134/S1819712413020050" }
Spasojević, N., Jovanović, P., Stanisavljevic, D., Stefanović, B.,& Dronjak, S.. (2013). Hypothalamic noradrenaline synthesis, uptake and storage in rats during adaptation to long-term individual housing. in Neurochemical Journal, 7(2), 139-143. https://doi.org/10.1134/S1819712413020050
Spasojević N, Jovanović P, Stanisavljevic D, Stefanović B, Dronjak S. Hypothalamic noradrenaline synthesis, uptake and storage in rats during adaptation to long-term individual housing. in Neurochemical Journal. 2013;7(2):139-143. doi:10.1134/S1819712413020050 .
Spasojević, Nataša, Jovanović, Predrag, Stanisavljevic, D., Stefanović, Bojana, Dronjak, Slađana, "Hypothalamic noradrenaline synthesis, uptake and storage in rats during adaptation to long-term individual housing" in Neurochemical Journal, 7, no. 2 (2013):139-143, https://doi.org/10.1134/S1819712413020050 . .