Gender Modulates Development of the Metabolic Syndrome Phenotype in Fructose-Fed Rats
2013
Authors
Korićanac, GoranĐorđević, Ana D.
Žakula, Zorica
Vojnovic-Milutinovic, Danijela
Tepavčević, Snežana
Velikovic, Natasa
Milosavljević, Tijana
Stojiljković, Mojca D.
Romić, Snježana Đ.
Matić, Gordana
Article
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We analyzed the effects of a fructose-rich diet (FRD) to test the assumption that the expression of metabolic syndrome phenotype is different in male and female rats. Two-way ANOVA revealed a significant effect of FRD on feeding behavior and carbohydrate/lipid metabolism. The increased caloric intake in FRD rats of both sexes was followed by a cluster of gender-specific changes typical for the metabolic syndrome. Female rats were characterized by decreased glycemia, increased triglycerides, enlarged visceral adipose tissue and increased absolute mass of liver, without changes in systolic blood pressure and insulin sensitivity. In contrast, male rats developed less disturbances in physical and biochemical characteristics, but blood pressure and insulin sensitivity were impaired by FRD. The results emphasize the detrimental effects of fructose consumption on cardiovascular risk and insulin action in males, whereas females are affected by other metabolic disturbances. These results suppor...t the idea of gender-dependent differences in the expression of the metabolic syndrome phenotype.
Keywords:
Fructose rich diet / metabolic syndrome / gender / glucose tolerance test / blood pressure / lipid metabolismSource:
Archives of Biological Sciences, 2013, 65, 2, 455-464Funding / projects:
- Role of steroid hormones in neuroendocrine adaptation to stress and pathophysiology of metabolic syndrome - molecular mechanisms and clinical implications (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41009)
DOI: 10.2298/ABS1302455K
ISSN: 0354-4664
WoS: 000318826000006
Scopus: 2-s2.0-84876991872
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VinčaTY - JOUR AU - Korićanac, Goran AU - Đorđević, Ana D. AU - Žakula, Zorica AU - Vojnovic-Milutinovic, Danijela AU - Tepavčević, Snežana AU - Velikovic, Natasa AU - Milosavljević, Tijana AU - Stojiljković, Mojca D. AU - Romić, Snježana Đ. AU - Matić, Gordana PY - 2013 UR - https://vinar.vin.bg.ac.rs/handle/123456789/5507 AB - We analyzed the effects of a fructose-rich diet (FRD) to test the assumption that the expression of metabolic syndrome phenotype is different in male and female rats. Two-way ANOVA revealed a significant effect of FRD on feeding behavior and carbohydrate/lipid metabolism. The increased caloric intake in FRD rats of both sexes was followed by a cluster of gender-specific changes typical for the metabolic syndrome. Female rats were characterized by decreased glycemia, increased triglycerides, enlarged visceral adipose tissue and increased absolute mass of liver, without changes in systolic blood pressure and insulin sensitivity. In contrast, male rats developed less disturbances in physical and biochemical characteristics, but blood pressure and insulin sensitivity were impaired by FRD. The results emphasize the detrimental effects of fructose consumption on cardiovascular risk and insulin action in males, whereas females are affected by other metabolic disturbances. These results support the idea of gender-dependent differences in the expression of the metabolic syndrome phenotype. T2 - Archives of Biological Sciences T1 - Gender Modulates Development of the Metabolic Syndrome Phenotype in Fructose-Fed Rats VL - 65 IS - 2 SP - 455 EP - 464 DO - 10.2298/ABS1302455K ER -
@article{ author = "Korićanac, Goran and Đorđević, Ana D. and Žakula, Zorica and Vojnovic-Milutinovic, Danijela and Tepavčević, Snežana and Velikovic, Natasa and Milosavljević, Tijana and Stojiljković, Mojca D. and Romić, Snježana Đ. and Matić, Gordana", year = "2013", abstract = "We analyzed the effects of a fructose-rich diet (FRD) to test the assumption that the expression of metabolic syndrome phenotype is different in male and female rats. Two-way ANOVA revealed a significant effect of FRD on feeding behavior and carbohydrate/lipid metabolism. The increased caloric intake in FRD rats of both sexes was followed by a cluster of gender-specific changes typical for the metabolic syndrome. Female rats were characterized by decreased glycemia, increased triglycerides, enlarged visceral adipose tissue and increased absolute mass of liver, without changes in systolic blood pressure and insulin sensitivity. In contrast, male rats developed less disturbances in physical and biochemical characteristics, but blood pressure and insulin sensitivity were impaired by FRD. The results emphasize the detrimental effects of fructose consumption on cardiovascular risk and insulin action in males, whereas females are affected by other metabolic disturbances. These results support the idea of gender-dependent differences in the expression of the metabolic syndrome phenotype.", journal = "Archives of Biological Sciences", title = "Gender Modulates Development of the Metabolic Syndrome Phenotype in Fructose-Fed Rats", volume = "65", number = "2", pages = "455-464", doi = "10.2298/ABS1302455K" }
Korićanac, G., Đorđević, A. D., Žakula, Z., Vojnovic-Milutinovic, D., Tepavčević, S., Velikovic, N., Milosavljević, T., Stojiljković, M. D., Romić, S. Đ.,& Matić, G.. (2013). Gender Modulates Development of the Metabolic Syndrome Phenotype in Fructose-Fed Rats. in Archives of Biological Sciences, 65(2), 455-464. https://doi.org/10.2298/ABS1302455K
Korićanac G, Đorđević AD, Žakula Z, Vojnovic-Milutinovic D, Tepavčević S, Velikovic N, Milosavljević T, Stojiljković MD, Romić SĐ, Matić G. Gender Modulates Development of the Metabolic Syndrome Phenotype in Fructose-Fed Rats. in Archives of Biological Sciences. 2013;65(2):455-464. doi:10.2298/ABS1302455K .
Korićanac, Goran, Đorđević, Ana D., Žakula, Zorica, Vojnovic-Milutinovic, Danijela, Tepavčević, Snežana, Velikovic, Natasa, Milosavljević, Tijana, Stojiljković, Mojca D., Romić, Snježana Đ., Matić, Gordana, "Gender Modulates Development of the Metabolic Syndrome Phenotype in Fructose-Fed Rats" in Archives of Biological Sciences, 65, no. 2 (2013):455-464, https://doi.org/10.2298/ABS1302455K . .