Changes in Hypothalamus-Pituitary-Adrenal Axis Following Transient Ischemic Attack
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2014
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Acute brain ischemia caused by transient ischemic attack initiates a complex sequence of events in the central nervous system and hypothalamic-pituitary-adrenal (HPA) axis which may ultimately culminate in neuronal and cell damage. The brain is highly susceptible to ischemia and in response to stress shows changes in morphology and chemistry that are largely reversible. These responses are known to modify the function of the HPA axis, but their mechanisms are not yet clear. Duration and size of the HPA axis activation are regulated by corticotropin-releasing hormone, vasopressin (AVP), and glucocorticoids, including cortisol. Numerous studies suggest that activation of these hormones following brain ischemia can result in neurohormonal dysfunction that can exacerbate long-term prognosis following stroke. These studies represent evidence that changes in the HPA axis play an important role in brain ischemia.
Ključne reči:
hypothalamic-pituitary-adrenal axis / acute brain ischemia / transient ischemic attack / strokeIzvor:
Angiology, 2014, 65, 8, 723-732Finansiranje / projekti:
- Karotidna bolest u Srbiji - patološka dinamika, prevencija, dijagnostika i inovativni terapijski postupci (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41002)
- Hormonska regulacija ekspresije i aktivnosti azot oksid sintaze i natrijum-kalijumove pumpe u eksperimentalnim modelima insulinske rezistencije, dijabetesa i kardiovaskularnih poremećaja (RS-MESTD-Basic Research (BR or ON)-173033)
DOI: 10.1177/0003319713503487
ISSN: 0003-3197; 1940-1574
PubMed: 24065626
WoS: 000340715700011
Scopus: 2-s2.0-84905898967
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Institucija/grupa
VinčaTY - JOUR AU - Radak, Đorđe J. AU - Resanović, Ivana AU - Isenović, Esma R. PY - 2014 UR - https://vinar.vin.bg.ac.rs/handle/123456789/54 AB - Acute brain ischemia caused by transient ischemic attack initiates a complex sequence of events in the central nervous system and hypothalamic-pituitary-adrenal (HPA) axis which may ultimately culminate in neuronal and cell damage. The brain is highly susceptible to ischemia and in response to stress shows changes in morphology and chemistry that are largely reversible. These responses are known to modify the function of the HPA axis, but their mechanisms are not yet clear. Duration and size of the HPA axis activation are regulated by corticotropin-releasing hormone, vasopressin (AVP), and glucocorticoids, including cortisol. Numerous studies suggest that activation of these hormones following brain ischemia can result in neurohormonal dysfunction that can exacerbate long-term prognosis following stroke. These studies represent evidence that changes in the HPA axis play an important role in brain ischemia. T2 - Angiology T1 - Changes in Hypothalamus-Pituitary-Adrenal Axis Following Transient Ischemic Attack VL - 65 IS - 8 SP - 723 EP - 732 DO - 10.1177/0003319713503487 ER -
@article{ author = "Radak, Đorđe J. and Resanović, Ivana and Isenović, Esma R.", year = "2014", abstract = "Acute brain ischemia caused by transient ischemic attack initiates a complex sequence of events in the central nervous system and hypothalamic-pituitary-adrenal (HPA) axis which may ultimately culminate in neuronal and cell damage. The brain is highly susceptible to ischemia and in response to stress shows changes in morphology and chemistry that are largely reversible. These responses are known to modify the function of the HPA axis, but their mechanisms are not yet clear. Duration and size of the HPA axis activation are regulated by corticotropin-releasing hormone, vasopressin (AVP), and glucocorticoids, including cortisol. Numerous studies suggest that activation of these hormones following brain ischemia can result in neurohormonal dysfunction that can exacerbate long-term prognosis following stroke. These studies represent evidence that changes in the HPA axis play an important role in brain ischemia.", journal = "Angiology", title = "Changes in Hypothalamus-Pituitary-Adrenal Axis Following Transient Ischemic Attack", volume = "65", number = "8", pages = "723-732", doi = "10.1177/0003319713503487" }
Radak, Đ. J., Resanović, I.,& Isenović, E. R.. (2014). Changes in Hypothalamus-Pituitary-Adrenal Axis Following Transient Ischemic Attack. in Angiology, 65(8), 723-732. https://doi.org/10.1177/0003319713503487
Radak ĐJ, Resanović I, Isenović ER. Changes in Hypothalamus-Pituitary-Adrenal Axis Following Transient Ischemic Attack. in Angiology. 2014;65(8):723-732. doi:10.1177/0003319713503487 .
Radak, Đorđe J., Resanović, Ivana, Isenović, Esma R., "Changes in Hypothalamus-Pituitary-Adrenal Axis Following Transient Ischemic Attack" in Angiology, 65, no. 8 (2014):723-732, https://doi.org/10.1177/0003319713503487 . .