ENOS Glu298Asp Polymorphism Is Associated with Development of Complicated Plaques in Patients from Serbia with Advanced Carotid Atherosclerosis
2013
Authors
Đurić, TamaraĐorđević, Ana
Lukić, Nikola
Anđelevski, Magdalena
Živković, Maja
Stanković, Aleksandra
Article (Published version)
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Nitric oxide inhibits adhesion of thrombocytes, proliferation and migration of smooth muscle cells and restricts oxidation of atherogenic low-density lipoproteins. Therefore, decreased production or activity of NO may play a role in the initiation, progression or complications of atherosclerosis. The aim of this study was to estimate the effect of Glu298Asp eNOS gene polymorphism on the individual risk for development of complicated carotid atherosclerotic plaque in patients from Serbia with advanced carotid atherosclerosis (CA) who had undergone endarterectomy. The study population included 233 patients. eNOS G894T gene polymorphism was identified by PCR and RFLP methods. Multivariate logistic regression analysis showed that Asp298Asp is an independent risk factor for the presence of complicated plaques in CA patients. Patients who were homozygous for the Asp298 allele had an adjusted OR of 4.36 for the development of complicated plaques compared to those that carry the Glu298 allele.... Further validation and replication studies are needed.
Keywords:
Carotid atherosclerosis / polymorphism / eNOS / oxidative stressSource:
Archives of Biological Sciences, 2013, 65, 1, 143-149Funding / projects:
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VinčaTY - JOUR AU - Đurić, Tamara AU - Đorđević, Ana AU - Lukić, Nikola AU - Anđelevski, Magdalena AU - Živković, Maja AU - Stanković, Aleksandra PY - 2013 UR - https://vinar.vin.bg.ac.rs/handle/123456789/5188 AB - Nitric oxide inhibits adhesion of thrombocytes, proliferation and migration of smooth muscle cells and restricts oxidation of atherogenic low-density lipoproteins. Therefore, decreased production or activity of NO may play a role in the initiation, progression or complications of atherosclerosis. The aim of this study was to estimate the effect of Glu298Asp eNOS gene polymorphism on the individual risk for development of complicated carotid atherosclerotic plaque in patients from Serbia with advanced carotid atherosclerosis (CA) who had undergone endarterectomy. The study population included 233 patients. eNOS G894T gene polymorphism was identified by PCR and RFLP methods. Multivariate logistic regression analysis showed that Asp298Asp is an independent risk factor for the presence of complicated plaques in CA patients. Patients who were homozygous for the Asp298 allele had an adjusted OR of 4.36 for the development of complicated plaques compared to those that carry the Glu298 allele. Further validation and replication studies are needed. T2 - Archives of Biological Sciences T1 - ENOS Glu298Asp Polymorphism Is Associated with Development of Complicated Plaques in Patients from Serbia with Advanced Carotid Atherosclerosis VL - 65 IS - 1 SP - 143 EP - 149 DO - 10.2298/ABS1301143D ER -
@article{ author = "Đurić, Tamara and Đorđević, Ana and Lukić, Nikola and Anđelevski, Magdalena and Živković, Maja and Stanković, Aleksandra", year = "2013", abstract = "Nitric oxide inhibits adhesion of thrombocytes, proliferation and migration of smooth muscle cells and restricts oxidation of atherogenic low-density lipoproteins. Therefore, decreased production or activity of NO may play a role in the initiation, progression or complications of atherosclerosis. The aim of this study was to estimate the effect of Glu298Asp eNOS gene polymorphism on the individual risk for development of complicated carotid atherosclerotic plaque in patients from Serbia with advanced carotid atherosclerosis (CA) who had undergone endarterectomy. The study population included 233 patients. eNOS G894T gene polymorphism was identified by PCR and RFLP methods. Multivariate logistic regression analysis showed that Asp298Asp is an independent risk factor for the presence of complicated plaques in CA patients. Patients who were homozygous for the Asp298 allele had an adjusted OR of 4.36 for the development of complicated plaques compared to those that carry the Glu298 allele. Further validation and replication studies are needed.", journal = "Archives of Biological Sciences", title = "ENOS Glu298Asp Polymorphism Is Associated with Development of Complicated Plaques in Patients from Serbia with Advanced Carotid Atherosclerosis", volume = "65", number = "1", pages = "143-149", doi = "10.2298/ABS1301143D" }
Đurić, T., Đorđević, A., Lukić, N., Anđelevski, M., Živković, M.,& Stanković, A.. (2013). ENOS Glu298Asp Polymorphism Is Associated with Development of Complicated Plaques in Patients from Serbia with Advanced Carotid Atherosclerosis. in Archives of Biological Sciences, 65(1), 143-149. https://doi.org/10.2298/ABS1301143D
Đurić T, Đorđević A, Lukić N, Anđelevski M, Živković M, Stanković A. ENOS Glu298Asp Polymorphism Is Associated with Development of Complicated Plaques in Patients from Serbia with Advanced Carotid Atherosclerosis. in Archives of Biological Sciences. 2013;65(1):143-149. doi:10.2298/ABS1301143D .
Đurić, Tamara, Đorđević, Ana, Lukić, Nikola, Anđelevski, Magdalena, Živković, Maja, Stanković, Aleksandra, "ENOS Glu298Asp Polymorphism Is Associated with Development of Complicated Plaques in Patients from Serbia with Advanced Carotid Atherosclerosis" in Archives of Biological Sciences, 65, no. 1 (2013):143-149, https://doi.org/10.2298/ABS1301143D . .