Correlation of Carotid Artery Disease Severity and Vasomotor Response of Cerebral Blood Vessels
Само за регистроване кориснике
2015
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
We assessed reactivity of cerebral vessels on hypercapnia in patients with carotid occlusive disease. The effects of vascular risk factors on carotid atherosclerosis and vasomotor reactivity (VMR) of cerebral arterioles were also examined. Patients (n = 50) with carotid stenosis (30% in 1 or both sides) were included; 30 patients acted as controls. Hypertension, hyperlipidemia, diabetes, cardiac diseases, inflammation, and smoking were recorded. Vasomotor reactivity was assessed with the apnea test by transcranial Doppler ultrasonography and estimated by flow velocity changes in the middle cerebral artery before and after hypercapnia induction. Vasomotor reactivity was defined by the breath holding index, and values under 0.69 were considered critical for VMR impairment. Vasomotor reactivity reduction was significant (P = .004) in patients with severe carotid stenosis ( GT 70%) and with symptomatic carotid disease (P LT .05). The risk factors did not significantly influence VMR reducti...on. Severe carotid stenosis impairs VMR and may increase the risk of stroke, especially in symptomatic patients.
Кључне речи:
carotid artery stenosis / vasomotor reactivity / cerebral vessels / hypercapnia / vascular risk factorsИзвор:
Angiology, 2015, 66, 5, 481-487Финансирање / пројекти:
- Каротидна болест у Србији - патолошка динамика, превенција, дијагностика и иновативни терапијски поступци (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41002)
- Хормонска регулација експресије и активности азот оксид синтазе и натријум-калијумове пумпе у експерименталним моделима инсулинске резистенције, дијабетеса и кардиоваскуларних поремећаја (RS-MESTD-Basic Research (BR or ON)-173033)
DOI: 10.1177/0003319714538312
ISSN: 0003-3197; 1940-1574
PubMed: 24904181
WoS: 000353588600011
Scopus: 2-s2.0-84928013877
Колекције
Институција/група
VinčaTY - JOUR AU - Krdzic, Ivana AU - Covickovic-Sternic, Nadezda AU - Katsiki, Niki AU - Isenović, Esma R. AU - Radak, Đorđe J. PY - 2015 UR - https://vinar.vin.bg.ac.rs/handle/123456789/516 AB - We assessed reactivity of cerebral vessels on hypercapnia in patients with carotid occlusive disease. The effects of vascular risk factors on carotid atherosclerosis and vasomotor reactivity (VMR) of cerebral arterioles were also examined. Patients (n = 50) with carotid stenosis (30% in 1 or both sides) were included; 30 patients acted as controls. Hypertension, hyperlipidemia, diabetes, cardiac diseases, inflammation, and smoking were recorded. Vasomotor reactivity was assessed with the apnea test by transcranial Doppler ultrasonography and estimated by flow velocity changes in the middle cerebral artery before and after hypercapnia induction. Vasomotor reactivity was defined by the breath holding index, and values under 0.69 were considered critical for VMR impairment. Vasomotor reactivity reduction was significant (P = .004) in patients with severe carotid stenosis ( GT 70%) and with symptomatic carotid disease (P LT .05). The risk factors did not significantly influence VMR reduction. Severe carotid stenosis impairs VMR and may increase the risk of stroke, especially in symptomatic patients. T2 - Angiology T1 - Correlation of Carotid Artery Disease Severity and Vasomotor Response of Cerebral Blood Vessels VL - 66 IS - 5 SP - 481 EP - 487 DO - 10.1177/0003319714538312 ER -
@article{ author = "Krdzic, Ivana and Covickovic-Sternic, Nadezda and Katsiki, Niki and Isenović, Esma R. and Radak, Đorđe J.", year = "2015", abstract = "We assessed reactivity of cerebral vessels on hypercapnia in patients with carotid occlusive disease. The effects of vascular risk factors on carotid atherosclerosis and vasomotor reactivity (VMR) of cerebral arterioles were also examined. Patients (n = 50) with carotid stenosis (30% in 1 or both sides) were included; 30 patients acted as controls. Hypertension, hyperlipidemia, diabetes, cardiac diseases, inflammation, and smoking were recorded. Vasomotor reactivity was assessed with the apnea test by transcranial Doppler ultrasonography and estimated by flow velocity changes in the middle cerebral artery before and after hypercapnia induction. Vasomotor reactivity was defined by the breath holding index, and values under 0.69 were considered critical for VMR impairment. Vasomotor reactivity reduction was significant (P = .004) in patients with severe carotid stenosis ( GT 70%) and with symptomatic carotid disease (P LT .05). The risk factors did not significantly influence VMR reduction. Severe carotid stenosis impairs VMR and may increase the risk of stroke, especially in symptomatic patients.", journal = "Angiology", title = "Correlation of Carotid Artery Disease Severity and Vasomotor Response of Cerebral Blood Vessels", volume = "66", number = "5", pages = "481-487", doi = "10.1177/0003319714538312" }
Krdzic, I., Covickovic-Sternic, N., Katsiki, N., Isenović, E. R.,& Radak, Đ. J.. (2015). Correlation of Carotid Artery Disease Severity and Vasomotor Response of Cerebral Blood Vessels. in Angiology, 66(5), 481-487. https://doi.org/10.1177/0003319714538312
Krdzic I, Covickovic-Sternic N, Katsiki N, Isenović ER, Radak ĐJ. Correlation of Carotid Artery Disease Severity and Vasomotor Response of Cerebral Blood Vessels. in Angiology. 2015;66(5):481-487. doi:10.1177/0003319714538312 .
Krdzic, Ivana, Covickovic-Sternic, Nadezda, Katsiki, Niki, Isenović, Esma R., Radak, Đorđe J., "Correlation of Carotid Artery Disease Severity and Vasomotor Response of Cerebral Blood Vessels" in Angiology, 66, no. 5 (2015):481-487, https://doi.org/10.1177/0003319714538312 . .