A new approach to the drug release kinetics of a discrete system: SiO2 system obtained by ultrasonic dry spraying
Апстракт
Mesoporous silica materials have already proved to be non-toxic and biocompatible, and also to have large pore volume and very high specific surface area suitable for loading of small molecules. Having this in mind and the fact that silicon dioxide (SiO2) powders can be so designed to obtain particle structures organized at multi levels, SiO2 was chosen as a potential carrier for metronidazole, an antibiotic drug. SiO2 powder was synthesized in two stages: first silica sol was prepared by hydrothermal synthesis and second the sol was converted into powder by dry spraying with simultaneous incorporation of the antibiotic into its structure. Scanning and transmission electron microscopy study revealed very complex structure and sub-structure of SiO2 particles. Cell viability tests were used for estimation of cytotoxicity of so synthesized SiO2. The drug release data showed that the system can provide drug release for a long time. Also, the device behavior is fully predictable, according ...to our theoretical model of multilevel structure design, and gives many opportunities for model investigations of drug release and its kinetics. The pore sizes and their distribution were observed as a limiting factor of drug release kinetics. Therefore, as the pore sizes are given as a set of discrete values, the kinetics of drug release might also be given as a set of corresponding discrete values. (c) 2012 Elsevier B.V. All rights reserved.
Кључне речи:
Drug release / Discrete kinetics / Substructure of SiO2 drug carrierИзвор:
Ultrasonics Sonochemistry, 2013, 20, 1, 535-545Финансирање / пројекти:
- Хемијско и структурно дизајнирање наноматеријала за примену у медицини и инжењерству ткива (RS-172026)
DOI: 10.1016/j.ultsonch.2012.08.015
ISSN: 1350-4177
PubMed: 23006998
WoS: 000311130000072
Scopus: 2-s2.0-84867742539
Колекције
Институција/група
VinčaTY - JOUR AU - Jokanović, Vukoman R. AU - Čolović, Božana M. AU - Sikirić, Dutour M. AU - Trajković, Vladimir S. PY - 2013 UR - https://vinar.vin.bg.ac.rs/handle/123456789/5166 AB - Mesoporous silica materials have already proved to be non-toxic and biocompatible, and also to have large pore volume and very high specific surface area suitable for loading of small molecules. Having this in mind and the fact that silicon dioxide (SiO2) powders can be so designed to obtain particle structures organized at multi levels, SiO2 was chosen as a potential carrier for metronidazole, an antibiotic drug. SiO2 powder was synthesized in two stages: first silica sol was prepared by hydrothermal synthesis and second the sol was converted into powder by dry spraying with simultaneous incorporation of the antibiotic into its structure. Scanning and transmission electron microscopy study revealed very complex structure and sub-structure of SiO2 particles. Cell viability tests were used for estimation of cytotoxicity of so synthesized SiO2. The drug release data showed that the system can provide drug release for a long time. Also, the device behavior is fully predictable, according to our theoretical model of multilevel structure design, and gives many opportunities for model investigations of drug release and its kinetics. The pore sizes and their distribution were observed as a limiting factor of drug release kinetics. Therefore, as the pore sizes are given as a set of discrete values, the kinetics of drug release might also be given as a set of corresponding discrete values. (c) 2012 Elsevier B.V. All rights reserved. T2 - Ultrasonics Sonochemistry T1 - A new approach to the drug release kinetics of a discrete system: SiO2 system obtained by ultrasonic dry spraying VL - 20 IS - 1 SP - 535 EP - 545 DO - 10.1016/j.ultsonch.2012.08.015 ER -
@article{ author = "Jokanović, Vukoman R. and Čolović, Božana M. and Sikirić, Dutour M. and Trajković, Vladimir S.", year = "2013", abstract = "Mesoporous silica materials have already proved to be non-toxic and biocompatible, and also to have large pore volume and very high specific surface area suitable for loading of small molecules. Having this in mind and the fact that silicon dioxide (SiO2) powders can be so designed to obtain particle structures organized at multi levels, SiO2 was chosen as a potential carrier for metronidazole, an antibiotic drug. SiO2 powder was synthesized in two stages: first silica sol was prepared by hydrothermal synthesis and second the sol was converted into powder by dry spraying with simultaneous incorporation of the antibiotic into its structure. Scanning and transmission electron microscopy study revealed very complex structure and sub-structure of SiO2 particles. Cell viability tests were used for estimation of cytotoxicity of so synthesized SiO2. The drug release data showed that the system can provide drug release for a long time. Also, the device behavior is fully predictable, according to our theoretical model of multilevel structure design, and gives many opportunities for model investigations of drug release and its kinetics. The pore sizes and their distribution were observed as a limiting factor of drug release kinetics. Therefore, as the pore sizes are given as a set of discrete values, the kinetics of drug release might also be given as a set of corresponding discrete values. (c) 2012 Elsevier B.V. All rights reserved.", journal = "Ultrasonics Sonochemistry", title = "A new approach to the drug release kinetics of a discrete system: SiO2 system obtained by ultrasonic dry spraying", volume = "20", number = "1", pages = "535-545", doi = "10.1016/j.ultsonch.2012.08.015" }
Jokanović, V. R., Čolović, B. M., Sikirić, D. M.,& Trajković, V. S.. (2013). A new approach to the drug release kinetics of a discrete system: SiO2 system obtained by ultrasonic dry spraying. in Ultrasonics Sonochemistry, 20(1), 535-545. https://doi.org/10.1016/j.ultsonch.2012.08.015
Jokanović VR, Čolović BM, Sikirić DM, Trajković VS. A new approach to the drug release kinetics of a discrete system: SiO2 system obtained by ultrasonic dry spraying. in Ultrasonics Sonochemistry. 2013;20(1):535-545. doi:10.1016/j.ultsonch.2012.08.015 .
Jokanović, Vukoman R., Čolović, Božana M., Sikirić, Dutour M., Trajković, Vladimir S., "A new approach to the drug release kinetics of a discrete system: SiO2 system obtained by ultrasonic dry spraying" in Ultrasonics Sonochemistry, 20, no. 1 (2013):535-545, https://doi.org/10.1016/j.ultsonch.2012.08.015 . .