Effects of altered hepatic lipid metabolism on regulation of hepatic iNOS
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Stanimirović, JulijanaObradović, Milan M.
Zafirović, Sonja
Resanović, Ivana
Bogdanović, Nikola
Gluvić, Zoran
Mousa, Shaker A.
Isenović, Esma R.
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An altered hepatic lipid metabolism involves multifactorial pathologies such as hepatic inflammation, insulin resistance and oxidative stress. Immunity has an essential role in the regulation of glucose and lipid metabolism in the liver. Inducible nitric oxide (NO) synthase (iNOS) has been proposed as an important factor that interplays between immunity and energy metabolism and also in the pathogenesis of obesity-linked insulin resistance. In the liver, locally produced NO plays a protective role during inflammation, and the balance of NO protective and cytotoxic effects is very important. This review is focused on understanding the molecular mechanisms of iNOS regulation in the state of altered hepatic lipid metabolism, which is critical for developing new strategies for treatment of hepatic disorders.
Keywords:
inducible nitric oxide synthase / inflammation / lipid / liver / metabolism / nitric oxideSource:
Clinical Lipidology, 2015, 10, 2, 167-175Funding / projects:
- Hormonal regulation of expression and activity of the nitric oxide synthase and sodium-potassium pump in experimental models of insulin resistance, diabetes and cardiovascular disorders (RS-MESTD-Basic Research (BR or ON)-173033)
DOI: 10.2217/CLP.15.8
ISSN: 1758-4299; 1758-4302
WoS: 000353412100006
Scopus: 2-s2.0-84928576652
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VinčaTY - JOUR AU - Stanimirović, Julijana AU - Obradović, Milan M. AU - Zafirović, Sonja AU - Resanović, Ivana AU - Bogdanović, Nikola AU - Gluvić, Zoran AU - Mousa, Shaker A. AU - Isenović, Esma R. PY - 2015 UR - https://vinar.vin.bg.ac.rs/handle/123456789/511 AB - An altered hepatic lipid metabolism involves multifactorial pathologies such as hepatic inflammation, insulin resistance and oxidative stress. Immunity has an essential role in the regulation of glucose and lipid metabolism in the liver. Inducible nitric oxide (NO) synthase (iNOS) has been proposed as an important factor that interplays between immunity and energy metabolism and also in the pathogenesis of obesity-linked insulin resistance. In the liver, locally produced NO plays a protective role during inflammation, and the balance of NO protective and cytotoxic effects is very important. This review is focused on understanding the molecular mechanisms of iNOS regulation in the state of altered hepatic lipid metabolism, which is critical for developing new strategies for treatment of hepatic disorders. T2 - Clinical Lipidology T1 - Effects of altered hepatic lipid metabolism on regulation of hepatic iNOS VL - 10 IS - 2 SP - 167 EP - 175 DO - 10.2217/CLP.15.8 ER -
@article{ author = "Stanimirović, Julijana and Obradović, Milan M. and Zafirović, Sonja and Resanović, Ivana and Bogdanović, Nikola and Gluvić, Zoran and Mousa, Shaker A. and Isenović, Esma R.", year = "2015", abstract = "An altered hepatic lipid metabolism involves multifactorial pathologies such as hepatic inflammation, insulin resistance and oxidative stress. Immunity has an essential role in the regulation of glucose and lipid metabolism in the liver. Inducible nitric oxide (NO) synthase (iNOS) has been proposed as an important factor that interplays between immunity and energy metabolism and also in the pathogenesis of obesity-linked insulin resistance. In the liver, locally produced NO plays a protective role during inflammation, and the balance of NO protective and cytotoxic effects is very important. This review is focused on understanding the molecular mechanisms of iNOS regulation in the state of altered hepatic lipid metabolism, which is critical for developing new strategies for treatment of hepatic disorders.", journal = "Clinical Lipidology", title = "Effects of altered hepatic lipid metabolism on regulation of hepatic iNOS", volume = "10", number = "2", pages = "167-175", doi = "10.2217/CLP.15.8" }
Stanimirović, J., Obradović, M. M., Zafirović, S., Resanović, I., Bogdanović, N., Gluvić, Z., Mousa, S. A.,& Isenović, E. R.. (2015). Effects of altered hepatic lipid metabolism on regulation of hepatic iNOS. in Clinical Lipidology, 10(2), 167-175. https://doi.org/10.2217/CLP.15.8
Stanimirović J, Obradović MM, Zafirović S, Resanović I, Bogdanović N, Gluvić Z, Mousa SA, Isenović ER. Effects of altered hepatic lipid metabolism on regulation of hepatic iNOS. in Clinical Lipidology. 2015;10(2):167-175. doi:10.2217/CLP.15.8 .
Stanimirović, Julijana, Obradović, Milan M., Zafirović, Sonja, Resanović, Ivana, Bogdanović, Nikola, Gluvić, Zoran, Mousa, Shaker A., Isenović, Esma R., "Effects of altered hepatic lipid metabolism on regulation of hepatic iNOS" in Clinical Lipidology, 10, no. 2 (2015):167-175, https://doi.org/10.2217/CLP.15.8 . .