Emulsion Templating of Poly(lactic acid) Particles: Droplet Formation Behavior
Abstract
Monodisperse poly(DL-lactic acid) (PLA) particles of diameters between 11 and 121 mu m were fabricated in flow focusing glass microcapillary devices by evaporation of dichloromethane (DCM) from emulsion droplets at room temperature. The dispersed phase was 5% (w/w) PLA in DCM containing 0.1-2 mM Nile Red and the continuous phase was 5% (w/w) poly(vinyl alcohol) in reverse osmosis water. Particle diameter was 2.7 times smaller than the diameter of the emulsion droplet template, indicating very low particle porosity. Monodisperse droplets have only been produced under dripping regime using a wide range of dispersed phase flow rates (0.002-7.2 cm(3).h(-1)), continuous phase flow rates (0.3-30 cm(3).h(-1)), and orifice diameters (50-237 mu m). In the dripping regime, the ratio of droplet diameter to orifice diameter was inversely proportional to the 0.39 power of the ratio of the continuous phase flow rate to dispersed phase flow rate. Highly uniform droplets with a coefficient of variatio...n (CV) below 2% and a ratio of the droplet diameter to orifice diameter of 0.5-1 were obtained at flow rate ratios of 4-25. Under jetting regime, polydisperse droplets (CV GT 6%) were formed by detachment from relatively long jets (between 4 and 10 times longer than droplet diameter) and a ratio of the droplet size to orifice size of 2-5.
Source:
Langmuir, 2012, 28, 36, 12948-12954Funding / projects:
- Engineering and Physical Sciences Research Council (EPSRC) of the United Kingdom [EP/HO29923/1]
DOI: 10.1021/la302092f
ISSN: 0743-7463
PubMed: 22860633
WoS: 000308839600003
Scopus: 2-s2.0-84866108686
Collections
Institution/Community
VinčaTY - JOUR AU - Vladisavljević, Goran T. AU - Duncanson, Wynter J. AU - Shum, Ho Cheung AU - Weitz, David A. PY - 2012 UR - https://vinar.vin.bg.ac.rs/handle/123456789/5039 AB - Monodisperse poly(DL-lactic acid) (PLA) particles of diameters between 11 and 121 mu m were fabricated in flow focusing glass microcapillary devices by evaporation of dichloromethane (DCM) from emulsion droplets at room temperature. The dispersed phase was 5% (w/w) PLA in DCM containing 0.1-2 mM Nile Red and the continuous phase was 5% (w/w) poly(vinyl alcohol) in reverse osmosis water. Particle diameter was 2.7 times smaller than the diameter of the emulsion droplet template, indicating very low particle porosity. Monodisperse droplets have only been produced under dripping regime using a wide range of dispersed phase flow rates (0.002-7.2 cm(3).h(-1)), continuous phase flow rates (0.3-30 cm(3).h(-1)), and orifice diameters (50-237 mu m). In the dripping regime, the ratio of droplet diameter to orifice diameter was inversely proportional to the 0.39 power of the ratio of the continuous phase flow rate to dispersed phase flow rate. Highly uniform droplets with a coefficient of variation (CV) below 2% and a ratio of the droplet diameter to orifice diameter of 0.5-1 were obtained at flow rate ratios of 4-25. Under jetting regime, polydisperse droplets (CV GT 6%) were formed by detachment from relatively long jets (between 4 and 10 times longer than droplet diameter) and a ratio of the droplet size to orifice size of 2-5. T2 - Langmuir T1 - Emulsion Templating of Poly(lactic acid) Particles: Droplet Formation Behavior VL - 28 IS - 36 SP - 12948 EP - 12954 DO - 10.1021/la302092f ER -
@article{ author = "Vladisavljević, Goran T. and Duncanson, Wynter J. and Shum, Ho Cheung and Weitz, David A.", year = "2012", abstract = "Monodisperse poly(DL-lactic acid) (PLA) particles of diameters between 11 and 121 mu m were fabricated in flow focusing glass microcapillary devices by evaporation of dichloromethane (DCM) from emulsion droplets at room temperature. The dispersed phase was 5% (w/w) PLA in DCM containing 0.1-2 mM Nile Red and the continuous phase was 5% (w/w) poly(vinyl alcohol) in reverse osmosis water. Particle diameter was 2.7 times smaller than the diameter of the emulsion droplet template, indicating very low particle porosity. Monodisperse droplets have only been produced under dripping regime using a wide range of dispersed phase flow rates (0.002-7.2 cm(3).h(-1)), continuous phase flow rates (0.3-30 cm(3).h(-1)), and orifice diameters (50-237 mu m). In the dripping regime, the ratio of droplet diameter to orifice diameter was inversely proportional to the 0.39 power of the ratio of the continuous phase flow rate to dispersed phase flow rate. Highly uniform droplets with a coefficient of variation (CV) below 2% and a ratio of the droplet diameter to orifice diameter of 0.5-1 were obtained at flow rate ratios of 4-25. Under jetting regime, polydisperse droplets (CV GT 6%) were formed by detachment from relatively long jets (between 4 and 10 times longer than droplet diameter) and a ratio of the droplet size to orifice size of 2-5.", journal = "Langmuir", title = "Emulsion Templating of Poly(lactic acid) Particles: Droplet Formation Behavior", volume = "28", number = "36", pages = "12948-12954", doi = "10.1021/la302092f" }
Vladisavljević, G. T., Duncanson, W. J., Shum, H. C.,& Weitz, D. A.. (2012). Emulsion Templating of Poly(lactic acid) Particles: Droplet Formation Behavior. in Langmuir, 28(36), 12948-12954. https://doi.org/10.1021/la302092f
Vladisavljević GT, Duncanson WJ, Shum HC, Weitz DA. Emulsion Templating of Poly(lactic acid) Particles: Droplet Formation Behavior. in Langmuir. 2012;28(36):12948-12954. doi:10.1021/la302092f .
Vladisavljević, Goran T., Duncanson, Wynter J., Shum, Ho Cheung, Weitz, David A., "Emulsion Templating of Poly(lactic acid) Particles: Droplet Formation Behavior" in Langmuir, 28, no. 36 (2012):12948-12954, https://doi.org/10.1021/la302092f . .