Antioxidant Protection against Curative and Palliative Doses of Ionizing Irradiation in Human Blood Decreases with Aging
2012
Аутори
Kasapović, JelenaStojiljković, Vesna
Gavrilović, Ljubica
Popović, Nataša M.
Milićević, Zorka T.
Чланак у часопису
Метаподаци
Приказ свих података о документуАпстракт
Reactive oxygen species (ROS) are independently recognized to play a significant role in radiation-induced damage on healthy tissue and in aging process. However, an age-related alteration of antioxidant (AO) system in radiation response in humans is poorly investigated. The aim of this paper was to evaluate the irradiation effects on the activities and expression of AO system in the blood of healthy women during aging. Blood samples were irradiated with curative and palliative doses of 2Gy or 9Gy gamma-rays. AO capacity for detoxification of O-2 center dot(-) and H2O2 in response to 2Gy gamma-irradiation decreases in women above 58 years, while in response to 9Gy shows signs of weakening after 45 years of age. Due to reduction of AO capacity during aging, cytotoxic effects of curative and palliative doses of irradiation, mediated by ROS, may significantly increase in older subjects, while removal of H2O2 excess could reduce them.
Извор:
Scientific World Journal, 2012Финансирање / пројекти:
- Ћелијске и молекулске основе малигних и кардиоваскуларних обољења-клиничке импликације (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41027)
- Молекуларно физиолошки биомониторинг аеробних организама заснован на одређивању биохемијских биомаркера оксидационог стреса (RS-MESTD-Basic Research (BR or ON)-173041)
DOI: 10.1100/2012/982594
ISSN: 1537-744X
WoS: 000306567300001
Scopus: 2-s2.0-84862337203
Колекције
Институција/група
VinčaTY - JOUR AU - Kasapović, Jelena AU - Stojiljković, Vesna AU - Gavrilović, Ljubica AU - Popović, Nataša M. AU - Milićević, Zorka T. PY - 2012 UR - https://vinar.vin.bg.ac.rs/handle/123456789/4959 AB - Reactive oxygen species (ROS) are independently recognized to play a significant role in radiation-induced damage on healthy tissue and in aging process. However, an age-related alteration of antioxidant (AO) system in radiation response in humans is poorly investigated. The aim of this paper was to evaluate the irradiation effects on the activities and expression of AO system in the blood of healthy women during aging. Blood samples were irradiated with curative and palliative doses of 2Gy or 9Gy gamma-rays. AO capacity for detoxification of O-2 center dot(-) and H2O2 in response to 2Gy gamma-irradiation decreases in women above 58 years, while in response to 9Gy shows signs of weakening after 45 years of age. Due to reduction of AO capacity during aging, cytotoxic effects of curative and palliative doses of irradiation, mediated by ROS, may significantly increase in older subjects, while removal of H2O2 excess could reduce them. T2 - Scientific World Journal T1 - Antioxidant Protection against Curative and Palliative Doses of Ionizing Irradiation in Human Blood Decreases with Aging DO - 10.1100/2012/982594 ER -
@article{ author = "Kasapović, Jelena and Stojiljković, Vesna and Gavrilović, Ljubica and Popović, Nataša M. and Milićević, Zorka T.", year = "2012", abstract = "Reactive oxygen species (ROS) are independently recognized to play a significant role in radiation-induced damage on healthy tissue and in aging process. However, an age-related alteration of antioxidant (AO) system in radiation response in humans is poorly investigated. The aim of this paper was to evaluate the irradiation effects on the activities and expression of AO system in the blood of healthy women during aging. Blood samples were irradiated with curative and palliative doses of 2Gy or 9Gy gamma-rays. AO capacity for detoxification of O-2 center dot(-) and H2O2 in response to 2Gy gamma-irradiation decreases in women above 58 years, while in response to 9Gy shows signs of weakening after 45 years of age. Due to reduction of AO capacity during aging, cytotoxic effects of curative and palliative doses of irradiation, mediated by ROS, may significantly increase in older subjects, while removal of H2O2 excess could reduce them.", journal = "Scientific World Journal", title = "Antioxidant Protection against Curative and Palliative Doses of Ionizing Irradiation in Human Blood Decreases with Aging", doi = "10.1100/2012/982594" }
Kasapović, J., Stojiljković, V., Gavrilović, L., Popović, N. M.,& Milićević, Z. T.. (2012). Antioxidant Protection against Curative and Palliative Doses of Ionizing Irradiation in Human Blood Decreases with Aging. in Scientific World Journal. https://doi.org/10.1100/2012/982594
Kasapović J, Stojiljković V, Gavrilović L, Popović NM, Milićević ZT. Antioxidant Protection against Curative and Palliative Doses of Ionizing Irradiation in Human Blood Decreases with Aging. in Scientific World Journal. 2012;. doi:10.1100/2012/982594 .
Kasapović, Jelena, Stojiljković, Vesna, Gavrilović, Ljubica, Popović, Nataša M., Milićević, Zorka T., "Antioxidant Protection against Curative and Palliative Doses of Ionizing Irradiation in Human Blood Decreases with Aging" in Scientific World Journal (2012), https://doi.org/10.1100/2012/982594 . .