Antioxidant Protection against Curative and Palliative Doses of Ionizing Irradiation in Human Blood Decreases with Aging
![](/themes/MirageVinar//images/openAccess.png)
2012
Authors
Kasapović, Jelena![](/themes/MirageVinar/images/orcid.png)
Stojiljković, Vesna
![](/themes/MirageVinar/images/orcid.png)
Gavrilović, Ljubica
![](/themes/MirageVinar/images/orcid.png)
Popović, Nataša M.
![](/themes/MirageVinar/images/orcid.png)
Milićević, Zorka T.
Article
Metadata
Show full item recordAbstract
Reactive oxygen species (ROS) are independently recognized to play a significant role in radiation-induced damage on healthy tissue and in aging process. However, an age-related alteration of antioxidant (AO) system in radiation response in humans is poorly investigated. The aim of this paper was to evaluate the irradiation effects on the activities and expression of AO system in the blood of healthy women during aging. Blood samples were irradiated with curative and palliative doses of 2Gy or 9Gy gamma-rays. AO capacity for detoxification of O-2 center dot(-) and H2O2 in response to 2Gy gamma-irradiation decreases in women above 58 years, while in response to 9Gy shows signs of weakening after 45 years of age. Due to reduction of AO capacity during aging, cytotoxic effects of curative and palliative doses of irradiation, mediated by ROS, may significantly increase in older subjects, while removal of H2O2 excess could reduce them.
Source:
Scientific World Journal, 2012Funding / projects:
- Cellular and molecular basis of malignant and cardiovascular diseases-clinical implications (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41027)
- Molecular and physiological biomonitoring of aerobic organisms based on the determination of biochemical biomarkers of oxidative stress (RS-MESTD-Basic Research (BR or ON)-173041)
DOI: 10.1100/2012/982594
ISSN: 1537-744X
WoS: 000306567300001
Scopus: 2-s2.0-84862337203
Collections
Institution/Community
VinčaTY - JOUR AU - Kasapović, Jelena AU - Stojiljković, Vesna AU - Gavrilović, Ljubica AU - Popović, Nataša M. AU - Milićević, Zorka T. PY - 2012 UR - https://vinar.vin.bg.ac.rs/handle/123456789/4959 AB - Reactive oxygen species (ROS) are independently recognized to play a significant role in radiation-induced damage on healthy tissue and in aging process. However, an age-related alteration of antioxidant (AO) system in radiation response in humans is poorly investigated. The aim of this paper was to evaluate the irradiation effects on the activities and expression of AO system in the blood of healthy women during aging. Blood samples were irradiated with curative and palliative doses of 2Gy or 9Gy gamma-rays. AO capacity for detoxification of O-2 center dot(-) and H2O2 in response to 2Gy gamma-irradiation decreases in women above 58 years, while in response to 9Gy shows signs of weakening after 45 years of age. Due to reduction of AO capacity during aging, cytotoxic effects of curative and palliative doses of irradiation, mediated by ROS, may significantly increase in older subjects, while removal of H2O2 excess could reduce them. T2 - Scientific World Journal T1 - Antioxidant Protection against Curative and Palliative Doses of Ionizing Irradiation in Human Blood Decreases with Aging DO - 10.1100/2012/982594 ER -
@article{ author = "Kasapović, Jelena and Stojiljković, Vesna and Gavrilović, Ljubica and Popović, Nataša M. and Milićević, Zorka T.", year = "2012", abstract = "Reactive oxygen species (ROS) are independently recognized to play a significant role in radiation-induced damage on healthy tissue and in aging process. However, an age-related alteration of antioxidant (AO) system in radiation response in humans is poorly investigated. The aim of this paper was to evaluate the irradiation effects on the activities and expression of AO system in the blood of healthy women during aging. Blood samples were irradiated with curative and palliative doses of 2Gy or 9Gy gamma-rays. AO capacity for detoxification of O-2 center dot(-) and H2O2 in response to 2Gy gamma-irradiation decreases in women above 58 years, while in response to 9Gy shows signs of weakening after 45 years of age. Due to reduction of AO capacity during aging, cytotoxic effects of curative and palliative doses of irradiation, mediated by ROS, may significantly increase in older subjects, while removal of H2O2 excess could reduce them.", journal = "Scientific World Journal", title = "Antioxidant Protection against Curative and Palliative Doses of Ionizing Irradiation in Human Blood Decreases with Aging", doi = "10.1100/2012/982594" }
Kasapović, J., Stojiljković, V., Gavrilović, L., Popović, N. M.,& Milićević, Z. T.. (2012). Antioxidant Protection against Curative and Palliative Doses of Ionizing Irradiation in Human Blood Decreases with Aging. in Scientific World Journal. https://doi.org/10.1100/2012/982594
Kasapović J, Stojiljković V, Gavrilović L, Popović NM, Milićević ZT. Antioxidant Protection against Curative and Palliative Doses of Ionizing Irradiation in Human Blood Decreases with Aging. in Scientific World Journal. 2012;. doi:10.1100/2012/982594 .
Kasapović, Jelena, Stojiljković, Vesna, Gavrilović, Ljubica, Popović, Nataša M., Milićević, Zorka T., "Antioxidant Protection against Curative and Palliative Doses of Ionizing Irradiation in Human Blood Decreases with Aging" in Scientific World Journal (2012), https://doi.org/10.1100/2012/982594 . .