The association of V249I and T280M fractalkine receptor haplotypes with disease course of multiple sclerosis
Nema prikaza
Autori
Stojković, Ljiljana S.Đurić, Tamara
Stanković, Aleksandra
Dinčić, Evica
Stančić, Olja
Veljković, Nevena V.
Alavantić, Dragan
Živković, Maja
Članak u časopisu
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
We investigated the association of CX3CR1 genotypes/haplotypes with MS and performed the prediction analysis of protein sequence variants effects on CX3CL1/CX3CR1 interaction. We found no association of CX3CR1 with MS susceptibility. Frequency of I249T280 haplotype was significantly lower in SP compared to RR patients (RR GT 10 years, OR=0.30, 95%CI=0.11-0.79, p=0.01: OR=0.53, 95%CI=0.18-1.56, p=0.2, in sP LT 10 years vs. RR GT 10 years). Prediction analysis showed that I249 T280 protein variant would significantly affect CX3CL1/CX3CR1 interaction. Our results suggest that CX3CR1 I249T280 haplotype could have protective effect for switch to SP MS. Further research is warranted to validate and replicate currently observed results. (C) 2012 Elsevier B.V. All rights reserved.
Ključne reči:
CX3CR1 / Polymorphism / V249I / T280M / Haplotypes / Multiple sclerosis / Clinical courseIzvor:
Journal of Neuroimmunology, 2012, 245, 1-2, 87-92Finansiranje / projekti:
- Genetska osnova humanih vaskularnih i inflamatornih bolesti (RS-MESTD-Basic Research (BR or ON)-175085)
- Primena EIIP/ISM bioinformatičke platforme u otkrivanju novih terapeutskih targeta i potencijalnih terapeutskih molekula (RS-MESTD-Basic Research (BR or ON)-173001)
DOI: 10.1016/j.jneuroim.2011.12.028
ISSN: 0165-5728; 1872-8421
PubMed: 22261545
WoS: 000303908100012
Scopus: 2-s2.0-84859637639
Kolekcije
Institucija/grupa
VinčaTY - JOUR AU - Stojković, Ljiljana S. AU - Đurić, Tamara AU - Stanković, Aleksandra AU - Dinčić, Evica AU - Stančić, Olja AU - Veljković, Nevena V. AU - Alavantić, Dragan AU - Živković, Maja PY - 2012 UR - https://vinar.vin.bg.ac.rs/handle/123456789/4841 AB - We investigated the association of CX3CR1 genotypes/haplotypes with MS and performed the prediction analysis of protein sequence variants effects on CX3CL1/CX3CR1 interaction. We found no association of CX3CR1 with MS susceptibility. Frequency of I249T280 haplotype was significantly lower in SP compared to RR patients (RR GT 10 years, OR=0.30, 95%CI=0.11-0.79, p=0.01: OR=0.53, 95%CI=0.18-1.56, p=0.2, in sP LT 10 years vs. RR GT 10 years). Prediction analysis showed that I249 T280 protein variant would significantly affect CX3CL1/CX3CR1 interaction. Our results suggest that CX3CR1 I249T280 haplotype could have protective effect for switch to SP MS. Further research is warranted to validate and replicate currently observed results. (C) 2012 Elsevier B.V. All rights reserved. T2 - Journal of Neuroimmunology T1 - The association of V249I and T280M fractalkine receptor haplotypes with disease course of multiple sclerosis VL - 245 IS - 1-2 SP - 87 EP - 92 DO - 10.1016/j.jneuroim.2011.12.028 ER -
@article{ author = "Stojković, Ljiljana S. and Đurić, Tamara and Stanković, Aleksandra and Dinčić, Evica and Stančić, Olja and Veljković, Nevena V. and Alavantić, Dragan and Živković, Maja", year = "2012", abstract = "We investigated the association of CX3CR1 genotypes/haplotypes with MS and performed the prediction analysis of protein sequence variants effects on CX3CL1/CX3CR1 interaction. We found no association of CX3CR1 with MS susceptibility. Frequency of I249T280 haplotype was significantly lower in SP compared to RR patients (RR GT 10 years, OR=0.30, 95%CI=0.11-0.79, p=0.01: OR=0.53, 95%CI=0.18-1.56, p=0.2, in sP LT 10 years vs. RR GT 10 years). Prediction analysis showed that I249 T280 protein variant would significantly affect CX3CL1/CX3CR1 interaction. Our results suggest that CX3CR1 I249T280 haplotype could have protective effect for switch to SP MS. Further research is warranted to validate and replicate currently observed results. (C) 2012 Elsevier B.V. All rights reserved.", journal = "Journal of Neuroimmunology", title = "The association of V249I and T280M fractalkine receptor haplotypes with disease course of multiple sclerosis", volume = "245", number = "1-2", pages = "87-92", doi = "10.1016/j.jneuroim.2011.12.028" }
Stojković, L. S., Đurić, T., Stanković, A., Dinčić, E., Stančić, O., Veljković, N. V., Alavantić, D.,& Živković, M.. (2012). The association of V249I and T280M fractalkine receptor haplotypes with disease course of multiple sclerosis. in Journal of Neuroimmunology, 245(1-2), 87-92. https://doi.org/10.1016/j.jneuroim.2011.12.028
Stojković LS, Đurić T, Stanković A, Dinčić E, Stančić O, Veljković NV, Alavantić D, Živković M. The association of V249I and T280M fractalkine receptor haplotypes with disease course of multiple sclerosis. in Journal of Neuroimmunology. 2012;245(1-2):87-92. doi:10.1016/j.jneuroim.2011.12.028 .
Stojković, Ljiljana S., Đurić, Tamara, Stanković, Aleksandra, Dinčić, Evica, Stančić, Olja, Veljković, Nevena V., Alavantić, Dragan, Živković, Maja, "The association of V249I and T280M fractalkine receptor haplotypes with disease course of multiple sclerosis" in Journal of Neuroimmunology, 245, no. 1-2 (2012):87-92, https://doi.org/10.1016/j.jneuroim.2011.12.028 . .