90Y-labeled tin fluoride colloid as a promising therapeutic agent: Preparation, characterization, and biological study in rats
No Thumbnail
Authors
Janković, DrinaVranješ-Đurić, Sanja
Đokić, Divna Đ.
Marković, Mirjana
Ajdinovic, Boris
Jaukovic, Ljiljana
Nikolić, Nadežda S.
Article
Metadata
Show full item recordAbstract
In this study, tin fluoride colloid (SnF-c) was prepared, labeled with yttrium-90 (90Y), and characterized with respect to its physicochemical properties and biological behavior in an animal model. Particle size of SnF-c, at constant concentration of SnF2, was dependent on pH, concentration of sodium fluoride (NaF), temperature, and time. The particle size of SnF-c decreased with an increase in NaF concentration and a decrease in reaction mixture pH. Radiolabeling yield of 90YSnF-c at higher temperature increased and it was greater than 98% for the preparation at 95 degrees C. The 90YSnF-c demonstrated high in vitro stability both in human serum and human synovial fluid at 37 degrees C up to 7 days. In vivo distribution studies in healthy male Wistar rats of 90YSnF-c (particles LT 1 mu m), following intravenous administration, revealed that the localization takes place preferably in the liver. The 90YSnF-c (particles GT 1 mu m) was well retained in the synovial space for 96 h after int...ra-articular injection, whereas leakage of 90Y from the joint was 1.96% over this period. Because of high labeling yield and stability, 90YSnF-c might be a promising agent for radiosynovectomy or therapy of liver malignancies. (C) 2012 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 101:21942203, 2012
Keywords:
90Y / radiolabeling / tin(II) fluoride colloid / chromatography / particle size / stability / microscopy / light-scattering / radiotherapySource:
Journal of Pharmaceutical Sciences, 2012, 101, 6, 2194-2203Funding / projects:
- Magnetic and radionuclide labeled nanostructured materials for medical applications (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45015)
- Cost Action [BM607], IAEA, CRP [14827/R0]
DOI: 10.1002/jps.23114
ISSN: 0022-3549
PubMed: 22415405
WoS: 000302800300024
Scopus: 2-s2.0-84859767748
Collections
Institution/Community
VinčaTY - JOUR AU - Janković, Drina AU - Vranješ-Đurić, Sanja AU - Đokić, Divna Đ. AU - Marković, Mirjana AU - Ajdinovic, Boris AU - Jaukovic, Ljiljana AU - Nikolić, Nadežda S. PY - 2012 UR - https://vinar.vin.bg.ac.rs/handle/123456789/4800 AB - In this study, tin fluoride colloid (SnF-c) was prepared, labeled with yttrium-90 (90Y), and characterized with respect to its physicochemical properties and biological behavior in an animal model. Particle size of SnF-c, at constant concentration of SnF2, was dependent on pH, concentration of sodium fluoride (NaF), temperature, and time. The particle size of SnF-c decreased with an increase in NaF concentration and a decrease in reaction mixture pH. Radiolabeling yield of 90YSnF-c at higher temperature increased and it was greater than 98% for the preparation at 95 degrees C. The 90YSnF-c demonstrated high in vitro stability both in human serum and human synovial fluid at 37 degrees C up to 7 days. In vivo distribution studies in healthy male Wistar rats of 90YSnF-c (particles LT 1 mu m), following intravenous administration, revealed that the localization takes place preferably in the liver. The 90YSnF-c (particles GT 1 mu m) was well retained in the synovial space for 96 h after intra-articular injection, whereas leakage of 90Y from the joint was 1.96% over this period. Because of high labeling yield and stability, 90YSnF-c might be a promising agent for radiosynovectomy or therapy of liver malignancies. (C) 2012 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 101:21942203, 2012 T2 - Journal of Pharmaceutical Sciences T1 - 90Y-labeled tin fluoride colloid as a promising therapeutic agent: Preparation, characterization, and biological study in rats VL - 101 IS - 6 SP - 2194 EP - 2203 DO - 10.1002/jps.23114 ER -
@article{ author = "Janković, Drina and Vranješ-Đurić, Sanja and Đokić, Divna Đ. and Marković, Mirjana and Ajdinovic, Boris and Jaukovic, Ljiljana and Nikolić, Nadežda S.", year = "2012", abstract = "In this study, tin fluoride colloid (SnF-c) was prepared, labeled with yttrium-90 (90Y), and characterized with respect to its physicochemical properties and biological behavior in an animal model. Particle size of SnF-c, at constant concentration of SnF2, was dependent on pH, concentration of sodium fluoride (NaF), temperature, and time. The particle size of SnF-c decreased with an increase in NaF concentration and a decrease in reaction mixture pH. Radiolabeling yield of 90YSnF-c at higher temperature increased and it was greater than 98% for the preparation at 95 degrees C. The 90YSnF-c demonstrated high in vitro stability both in human serum and human synovial fluid at 37 degrees C up to 7 days. In vivo distribution studies in healthy male Wistar rats of 90YSnF-c (particles LT 1 mu m), following intravenous administration, revealed that the localization takes place preferably in the liver. The 90YSnF-c (particles GT 1 mu m) was well retained in the synovial space for 96 h after intra-articular injection, whereas leakage of 90Y from the joint was 1.96% over this period. Because of high labeling yield and stability, 90YSnF-c might be a promising agent for radiosynovectomy or therapy of liver malignancies. (C) 2012 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 101:21942203, 2012", journal = "Journal of Pharmaceutical Sciences", title = "90Y-labeled tin fluoride colloid as a promising therapeutic agent: Preparation, characterization, and biological study in rats", volume = "101", number = "6", pages = "2194-2203", doi = "10.1002/jps.23114" }
Janković, D., Vranješ-Đurić, S., Đokić, D. Đ., Marković, M., Ajdinovic, B., Jaukovic, L.,& Nikolić, N. S.. (2012). 90Y-labeled tin fluoride colloid as a promising therapeutic agent: Preparation, characterization, and biological study in rats. in Journal of Pharmaceutical Sciences, 101(6), 2194-2203. https://doi.org/10.1002/jps.23114
Janković D, Vranješ-Đurić S, Đokić DĐ, Marković M, Ajdinovic B, Jaukovic L, Nikolić NS. 90Y-labeled tin fluoride colloid as a promising therapeutic agent: Preparation, characterization, and biological study in rats. in Journal of Pharmaceutical Sciences. 2012;101(6):2194-2203. doi:10.1002/jps.23114 .
Janković, Drina, Vranješ-Đurić, Sanja, Đokić, Divna Đ., Marković, Mirjana, Ajdinovic, Boris, Jaukovic, Ljiljana, Nikolić, Nadežda S., "90Y-labeled tin fluoride colloid as a promising therapeutic agent: Preparation, characterization, and biological study in rats" in Journal of Pharmaceutical Sciences, 101, no. 6 (2012):2194-2203, https://doi.org/10.1002/jps.23114 . .