Assessment of Hepatitis C Virus Protein Sequences with Regard to Interferon/Ribavirin Combination Therapy Response in Patients with HCV Genotype 1b
Samo za registrovane korisnike
2012
Autori
Glišić, SanjaVeljković, Nevena V.
Jovanović-Ćupić, Snežana P.
Vasiljevic, Nada
Prljić, Jelena
Gemović, Branislava S.
Perović, Vladimir R.
Veljković, Veljko
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Hepatitis C virus (HCV) infection is a major and rising global health problem, affecting about 170 million people worldwide. The current standard of care treatment with interferon alpha and ribavirin in patients with the genotype 1 infection, the most frequent genotype in the USA and Western Europe, leads to a successful outcome in only about 50% of individuals. Accurate prediction of hepatitis C treatment response is of great benefit to patients and clinicians. The informational spectrum method, a virtual spectroscopy method for structure/function analysis of nucleotide and protein sequences, is applied here for the identification of the conserved information of the HCV proteins that correlate with the combination therapy outcome. Among the HCV proteins that we have analyzed the informational property of the p7 of HCV genotype 1b was best related to the therapy outcome. On the basis of these results, a simple bioinformatics criterion that could be useful in assessment of the response ...of HCV-infected patients to the combination therapy has been proposed.
Ključne reči:
Hepatitis C virus / Bioinformatics / Informational spectrum method / Protein sequence / In silico HCV treatment response assessmentIzvor:
Protein Journal, 2012, 31, 2, 129-136Finansiranje / projekti:
- Primena EIIP/ISM bioinformatičke platforme u otkrivanju novih terapeutskih targeta i potencijalnih terapeutskih molekula (RS-MESTD-Basic Research (BR or ON)-173001)
DOI: 10.1007/s10930-011-9381-6
ISSN: 1572-3887; 1573-4943
PubMed: 22170451
WoS: 000301881200003
Scopus: 2-s2.0-84861094396
Kolekcije
Institucija/grupa
VinčaTY - JOUR AU - Glišić, Sanja AU - Veljković, Nevena V. AU - Jovanović-Ćupić, Snežana P. AU - Vasiljevic, Nada AU - Prljić, Jelena AU - Gemović, Branislava S. AU - Perović, Vladimir R. AU - Veljković, Veljko PY - 2012 UR - https://vinar.vin.bg.ac.rs/handle/123456789/4755 AB - Hepatitis C virus (HCV) infection is a major and rising global health problem, affecting about 170 million people worldwide. The current standard of care treatment with interferon alpha and ribavirin in patients with the genotype 1 infection, the most frequent genotype in the USA and Western Europe, leads to a successful outcome in only about 50% of individuals. Accurate prediction of hepatitis C treatment response is of great benefit to patients and clinicians. The informational spectrum method, a virtual spectroscopy method for structure/function analysis of nucleotide and protein sequences, is applied here for the identification of the conserved information of the HCV proteins that correlate with the combination therapy outcome. Among the HCV proteins that we have analyzed the informational property of the p7 of HCV genotype 1b was best related to the therapy outcome. On the basis of these results, a simple bioinformatics criterion that could be useful in assessment of the response of HCV-infected patients to the combination therapy has been proposed. T2 - Protein Journal T1 - Assessment of Hepatitis C Virus Protein Sequences with Regard to Interferon/Ribavirin Combination Therapy Response in Patients with HCV Genotype 1b VL - 31 IS - 2 SP - 129 EP - 136 DO - 10.1007/s10930-011-9381-6 ER -
@article{ author = "Glišić, Sanja and Veljković, Nevena V. and Jovanović-Ćupić, Snežana P. and Vasiljevic, Nada and Prljić, Jelena and Gemović, Branislava S. and Perović, Vladimir R. and Veljković, Veljko", year = "2012", abstract = "Hepatitis C virus (HCV) infection is a major and rising global health problem, affecting about 170 million people worldwide. The current standard of care treatment with interferon alpha and ribavirin in patients with the genotype 1 infection, the most frequent genotype in the USA and Western Europe, leads to a successful outcome in only about 50% of individuals. Accurate prediction of hepatitis C treatment response is of great benefit to patients and clinicians. The informational spectrum method, a virtual spectroscopy method for structure/function analysis of nucleotide and protein sequences, is applied here for the identification of the conserved information of the HCV proteins that correlate with the combination therapy outcome. Among the HCV proteins that we have analyzed the informational property of the p7 of HCV genotype 1b was best related to the therapy outcome. On the basis of these results, a simple bioinformatics criterion that could be useful in assessment of the response of HCV-infected patients to the combination therapy has been proposed.", journal = "Protein Journal", title = "Assessment of Hepatitis C Virus Protein Sequences with Regard to Interferon/Ribavirin Combination Therapy Response in Patients with HCV Genotype 1b", volume = "31", number = "2", pages = "129-136", doi = "10.1007/s10930-011-9381-6" }
Glišić, S., Veljković, N. V., Jovanović-Ćupić, S. P., Vasiljevic, N., Prljić, J., Gemović, B. S., Perović, V. R.,& Veljković, V.. (2012). Assessment of Hepatitis C Virus Protein Sequences with Regard to Interferon/Ribavirin Combination Therapy Response in Patients with HCV Genotype 1b. in Protein Journal, 31(2), 129-136. https://doi.org/10.1007/s10930-011-9381-6
Glišić S, Veljković NV, Jovanović-Ćupić SP, Vasiljevic N, Prljić J, Gemović BS, Perović VR, Veljković V. Assessment of Hepatitis C Virus Protein Sequences with Regard to Interferon/Ribavirin Combination Therapy Response in Patients with HCV Genotype 1b. in Protein Journal. 2012;31(2):129-136. doi:10.1007/s10930-011-9381-6 .
Glišić, Sanja, Veljković, Nevena V., Jovanović-Ćupić, Snežana P., Vasiljevic, Nada, Prljić, Jelena, Gemović, Branislava S., Perović, Vladimir R., Veljković, Veljko, "Assessment of Hepatitis C Virus Protein Sequences with Regard to Interferon/Ribavirin Combination Therapy Response in Patients with HCV Genotype 1b" in Protein Journal, 31, no. 2 (2012):129-136, https://doi.org/10.1007/s10930-011-9381-6 . .