The association of ACE I/D gene polymorphism with severe carotid atherosclerosis in patients undergoing carotid endarterectomy
2012
Authors
Kolaković, AnaŽivković, Maja
Radak, Đorđe J.
Đurić, Tamara
Končar, Igor
Davidović, Lazar
Dinčić, Dragan
Alavantić, Dragan
Stanković, Aleksandra
Article
Metadata
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Introduction: The ACE I/D polymorphism was mostly investigated in association with intima-media thickness, rarely with severe atherosclerotic phenotype. Materials and methods: We investigated the association of I/D polymorphism with severe carotid atherosclerosis (CA) (stenosis GT 70%) in asymptomatic and symptomatic patients undergoing carotid endarterectomy. The 504 patients subjected to endarterectomy and 492 healthy controls from a population in Serbia were investigated as a case-control study. Results: The univariate logistic regression analysis revealed ACE DD as a significant risk factor for severe CA (odds ratio [OR] = 1.3, 95% confidence interval [CI] 1.0-1.7, p = 0.04). After adjustment for the common risk factors (age, hypertension, smoking, and HDL) ACE was no longer significant. However, we found a significant independent influence of DD genotype on plaque presence in a normotensive subgroup of patients (OR 1.8, CI 1.2-3.0, p = 0.01, corrected for multiple testing). In sym...ptomatic patients D allele carriers were significantly more frequent compared with asymptomatic patients (OR 1.6 CI 1.0-2.6, p = 0.05). Conclusions: Our data suggests that ACE I/D is not an independent risk factor for severe CA. On the other hand, a significant independent genetic influence of ACE I/D appeared in normotensive and symptomatic patients with severe CA. This should be considered in further research toward resolving the complex genetic background of severe CA phenotype.
Keywords:
ACE I / D / carotid plaque / endarterectomy / gene / polymorphismSource:
Journal of the Renin-Angiotensin-Aldosterone System, 2012, 13, 1, 141-147Funding / projects:
- Genetic basis of human vascular and inflammatory diseases (RS-MESTD-Basic Research (BR or ON)-175085)
- An integral study to identify the regional genetic and environmental risk factors for the common noncommunicable diseases in the human population of Serbia - INGEMA_S (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41028)
DOI: 10.1177/1470320311423271
ISSN: 1470-3203
PubMed: 21984781
WoS: 000300993400019
Scopus: 2-s2.0-84859969050
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VinčaTY - JOUR AU - Kolaković, Ana AU - Živković, Maja AU - Radak, Đorđe J. AU - Đurić, Tamara AU - Končar, Igor AU - Davidović, Lazar AU - Dinčić, Dragan AU - Alavantić, Dragan AU - Stanković, Aleksandra PY - 2012 UR - https://vinar.vin.bg.ac.rs/handle/123456789/4719 AB - Introduction: The ACE I/D polymorphism was mostly investigated in association with intima-media thickness, rarely with severe atherosclerotic phenotype. Materials and methods: We investigated the association of I/D polymorphism with severe carotid atherosclerosis (CA) (stenosis GT 70%) in asymptomatic and symptomatic patients undergoing carotid endarterectomy. The 504 patients subjected to endarterectomy and 492 healthy controls from a population in Serbia were investigated as a case-control study. Results: The univariate logistic regression analysis revealed ACE DD as a significant risk factor for severe CA (odds ratio [OR] = 1.3, 95% confidence interval [CI] 1.0-1.7, p = 0.04). After adjustment for the common risk factors (age, hypertension, smoking, and HDL) ACE was no longer significant. However, we found a significant independent influence of DD genotype on plaque presence in a normotensive subgroup of patients (OR 1.8, CI 1.2-3.0, p = 0.01, corrected for multiple testing). In symptomatic patients D allele carriers were significantly more frequent compared with asymptomatic patients (OR 1.6 CI 1.0-2.6, p = 0.05). Conclusions: Our data suggests that ACE I/D is not an independent risk factor for severe CA. On the other hand, a significant independent genetic influence of ACE I/D appeared in normotensive and symptomatic patients with severe CA. This should be considered in further research toward resolving the complex genetic background of severe CA phenotype. T2 - Journal of the Renin-Angiotensin-Aldosterone System T1 - The association of ACE I/D gene polymorphism with severe carotid atherosclerosis in patients undergoing carotid endarterectomy VL - 13 IS - 1 SP - 141 EP - 147 DO - 10.1177/1470320311423271 ER -
@article{ author = "Kolaković, Ana and Živković, Maja and Radak, Đorđe J. and Đurić, Tamara and Končar, Igor and Davidović, Lazar and Dinčić, Dragan and Alavantić, Dragan and Stanković, Aleksandra", year = "2012", abstract = "Introduction: The ACE I/D polymorphism was mostly investigated in association with intima-media thickness, rarely with severe atherosclerotic phenotype. Materials and methods: We investigated the association of I/D polymorphism with severe carotid atherosclerosis (CA) (stenosis GT 70%) in asymptomatic and symptomatic patients undergoing carotid endarterectomy. The 504 patients subjected to endarterectomy and 492 healthy controls from a population in Serbia were investigated as a case-control study. Results: The univariate logistic regression analysis revealed ACE DD as a significant risk factor for severe CA (odds ratio [OR] = 1.3, 95% confidence interval [CI] 1.0-1.7, p = 0.04). After adjustment for the common risk factors (age, hypertension, smoking, and HDL) ACE was no longer significant. However, we found a significant independent influence of DD genotype on plaque presence in a normotensive subgroup of patients (OR 1.8, CI 1.2-3.0, p = 0.01, corrected for multiple testing). In symptomatic patients D allele carriers were significantly more frequent compared with asymptomatic patients (OR 1.6 CI 1.0-2.6, p = 0.05). Conclusions: Our data suggests that ACE I/D is not an independent risk factor for severe CA. On the other hand, a significant independent genetic influence of ACE I/D appeared in normotensive and symptomatic patients with severe CA. This should be considered in further research toward resolving the complex genetic background of severe CA phenotype.", journal = "Journal of the Renin-Angiotensin-Aldosterone System", title = "The association of ACE I/D gene polymorphism with severe carotid atherosclerosis in patients undergoing carotid endarterectomy", volume = "13", number = "1", pages = "141-147", doi = "10.1177/1470320311423271" }
Kolaković, A., Živković, M., Radak, Đ. J., Đurić, T., Končar, I., Davidović, L., Dinčić, D., Alavantić, D.,& Stanković, A.. (2012). The association of ACE I/D gene polymorphism with severe carotid atherosclerosis in patients undergoing carotid endarterectomy. in Journal of the Renin-Angiotensin-Aldosterone System, 13(1), 141-147. https://doi.org/10.1177/1470320311423271
Kolaković A, Živković M, Radak ĐJ, Đurić T, Končar I, Davidović L, Dinčić D, Alavantić D, Stanković A. The association of ACE I/D gene polymorphism with severe carotid atherosclerosis in patients undergoing carotid endarterectomy. in Journal of the Renin-Angiotensin-Aldosterone System. 2012;13(1):141-147. doi:10.1177/1470320311423271 .
Kolaković, Ana, Živković, Maja, Radak, Đorđe J., Đurić, Tamara, Končar, Igor, Davidović, Lazar, Dinčić, Dragan, Alavantić, Dragan, Stanković, Aleksandra, "The association of ACE I/D gene polymorphism with severe carotid atherosclerosis in patients undergoing carotid endarterectomy" in Journal of the Renin-Angiotensin-Aldosterone System, 13, no. 1 (2012):141-147, https://doi.org/10.1177/1470320311423271 . .