Fluoxetine Decreases Glutathione Reductase in Erythrocytes of Chronically Isolated Wistar Rats
Само за регистроване кориснике
2011
Аутори
Adžić, MiroslavĐorđević, Jelena D.
Mitić, Miloš
Simić, Iva
Rackov, Gorjana
Đorđević, Ana D.
Elaković, Ivana
Matić, Gordana
Radojčić, Marija
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Alterations in the antioxidative defense parameters upon chronic stress are considered critical for pathophysiology of stress related psychiatric disorders, and their status in blood serves as biomarker for effects of pharmacological treatments. The present study was designed to investigate the modulation of erythrocyte antioxidant enzymes (AOEs): CuZn superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GLR) activities and their protein expression in Wistar male rats subjected to chronic psychosocial isolation and/or to pharmacological treatment with fluoxetine. Chronically isolated animals exhibited decreased levels of serum corticosterone, as opposed to other chronic stress paradigms. In addition to that, SOD, CAT and GPx status was not altered either by chronic psychosocial isolation or by fluoxetine treatment. In contrast, GLR activity and its protein level were both markedly reduced by fluoxetine. Since, GLR is crucial for overal...l oxido-reductive balance through maintaining optimal ratio of reduced/oxidized glutathione level (GSH/GSSG) in erythrocytes, these results could indicate that in spite of numerous beneficial effects of fluoxetine, it may compromise both haemoglobin function and oxygen transport.
Кључне речи:
Fluoxetine / glutathione reductase / erythrocytes / chronic isolation / Wistar ratИзвор:
Acta Chimica Slovenica, 2011, 58, 4, 785-791Финансирање / пројекти:
- Ministry of Science of the Republic of Serbia [143042B, 43003]
ISSN: 1318-0207; 1580-3155
PubMed: 24061129
WoS: 000298811900020
Scopus: 2-s2.0-84255201627
Колекције
Институција/група
VinčaTY - JOUR AU - Adžić, Miroslav AU - Đorđević, Jelena D. AU - Mitić, Miloš AU - Simić, Iva AU - Rackov, Gorjana AU - Đorđević, Ana D. AU - Elaković, Ivana AU - Matić, Gordana AU - Radojčić, Marija PY - 2011 UR - https://vinar.vin.bg.ac.rs/handle/123456789/4640 AB - Alterations in the antioxidative defense parameters upon chronic stress are considered critical for pathophysiology of stress related psychiatric disorders, and their status in blood serves as biomarker for effects of pharmacological treatments. The present study was designed to investigate the modulation of erythrocyte antioxidant enzymes (AOEs): CuZn superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GLR) activities and their protein expression in Wistar male rats subjected to chronic psychosocial isolation and/or to pharmacological treatment with fluoxetine. Chronically isolated animals exhibited decreased levels of serum corticosterone, as opposed to other chronic stress paradigms. In addition to that, SOD, CAT and GPx status was not altered either by chronic psychosocial isolation or by fluoxetine treatment. In contrast, GLR activity and its protein level were both markedly reduced by fluoxetine. Since, GLR is crucial for overall oxido-reductive balance through maintaining optimal ratio of reduced/oxidized glutathione level (GSH/GSSG) in erythrocytes, these results could indicate that in spite of numerous beneficial effects of fluoxetine, it may compromise both haemoglobin function and oxygen transport. T2 - Acta Chimica Slovenica T1 - Fluoxetine Decreases Glutathione Reductase in Erythrocytes of Chronically Isolated Wistar Rats VL - 58 IS - 4 SP - 785 EP - 791 UR - https://hdl.handle.net/21.15107/rcub_vinar_4640 ER -
@article{ author = "Adžić, Miroslav and Đorđević, Jelena D. and Mitić, Miloš and Simić, Iva and Rackov, Gorjana and Đorđević, Ana D. and Elaković, Ivana and Matić, Gordana and Radojčić, Marija", year = "2011", abstract = "Alterations in the antioxidative defense parameters upon chronic stress are considered critical for pathophysiology of stress related psychiatric disorders, and their status in blood serves as biomarker for effects of pharmacological treatments. The present study was designed to investigate the modulation of erythrocyte antioxidant enzymes (AOEs): CuZn superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GLR) activities and their protein expression in Wistar male rats subjected to chronic psychosocial isolation and/or to pharmacological treatment with fluoxetine. Chronically isolated animals exhibited decreased levels of serum corticosterone, as opposed to other chronic stress paradigms. In addition to that, SOD, CAT and GPx status was not altered either by chronic psychosocial isolation or by fluoxetine treatment. In contrast, GLR activity and its protein level were both markedly reduced by fluoxetine. Since, GLR is crucial for overall oxido-reductive balance through maintaining optimal ratio of reduced/oxidized glutathione level (GSH/GSSG) in erythrocytes, these results could indicate that in spite of numerous beneficial effects of fluoxetine, it may compromise both haemoglobin function and oxygen transport.", journal = "Acta Chimica Slovenica", title = "Fluoxetine Decreases Glutathione Reductase in Erythrocytes of Chronically Isolated Wistar Rats", volume = "58", number = "4", pages = "785-791", url = "https://hdl.handle.net/21.15107/rcub_vinar_4640" }
Adžić, M., Đorđević, J. D., Mitić, M., Simić, I., Rackov, G., Đorđević, A. D., Elaković, I., Matić, G.,& Radojčić, M.. (2011). Fluoxetine Decreases Glutathione Reductase in Erythrocytes of Chronically Isolated Wistar Rats. in Acta Chimica Slovenica, 58(4), 785-791. https://hdl.handle.net/21.15107/rcub_vinar_4640
Adžić M, Đorđević JD, Mitić M, Simić I, Rackov G, Đorđević AD, Elaković I, Matić G, Radojčić M. Fluoxetine Decreases Glutathione Reductase in Erythrocytes of Chronically Isolated Wistar Rats. in Acta Chimica Slovenica. 2011;58(4):785-791. https://hdl.handle.net/21.15107/rcub_vinar_4640 .
Adžić, Miroslav, Đorđević, Jelena D., Mitić, Miloš, Simić, Iva, Rackov, Gorjana, Đorđević, Ana D., Elaković, Ivana, Matić, Gordana, Radojčić, Marija, "Fluoxetine Decreases Glutathione Reductase in Erythrocytes of Chronically Isolated Wistar Rats" in Acta Chimica Slovenica, 58, no. 4 (2011):785-791, https://hdl.handle.net/21.15107/rcub_vinar_4640 .