Regulation of atrial catecholamine enzymes and adrenoceptor gene expression after chronic stress
Apstrakt
Chronic stress is a risk factor for the development of numerous psychopathological conditions in humans including depression. Changes in gene expression of tyrosine-hydroxylase (TH), dopamine-beta-hydroxylase (DBH) phenylethanolamine N-methyltransferase (PNMT), beta(1)-, beta(2)-and beta(3)-adrenoceptors in right and left rat atria upon chronic unpredictable mild stress (CMS) were investigated. CMS decreased TH and DBH gene expression levels both in right and left atria and increased PNMT mRNA in left atria. No changes in mRNA levels of beta(1)-and beta(2) adrenoceptors were recorded, whereas beta(3)-adrenoreceptor mRNA level was significantly elevated in right atria of CMS rats. At the same time, CMS produced a significant increase of beta(1)-and beta(2)-adrenoreceptor mRNA levels in left atria, but did not affect beta(3)-adrenoceptor mRNA level. The results presented here suggest that stress-induced depression expressed differential effects on catecholamine biosynthetic enzymes and b...eta-adrenoceptors at molecular level in right and left atria of adult rat males. Elevated gene expression of PNMT in left atria of rats exposed to CMS can lead to altered physiological esponse and may play a role in the pathophysiology of cardiovascular function.
Ključne reči:
atria / catecholamine enzymes / beta-adrenoceptors / gene expression / stress / gene expression / mRNA / stress-induced depressionIzvor:
Acta Physiologica Hungarica, 2011, 98, 4, 433-441Finansiranje / projekti:
- Molekularni mehanizmi patofizioloških promena u ćelijama centralnog nervnog sistema i perifernog tkiva kod sisara (RS-MESTD-Basic Research (BR or ON)-173044)
DOI: 10.1556/APhysiol.98.2011.4.6
ISSN: 0231-424X
PubMed: 22173024
WoS: 000298107500006
Scopus: 2-s2.0-84255201493
Kolekcije
Institucija/grupa
VinčaTY - JOUR AU - Spasojević, Nataša AU - Gavrilović, Ljubica AU - Dronjak, Slađana PY - 2011 UR - https://vinar.vin.bg.ac.rs/handle/123456789/4610 AB - Chronic stress is a risk factor for the development of numerous psychopathological conditions in humans including depression. Changes in gene expression of tyrosine-hydroxylase (TH), dopamine-beta-hydroxylase (DBH) phenylethanolamine N-methyltransferase (PNMT), beta(1)-, beta(2)-and beta(3)-adrenoceptors in right and left rat atria upon chronic unpredictable mild stress (CMS) were investigated. CMS decreased TH and DBH gene expression levels both in right and left atria and increased PNMT mRNA in left atria. No changes in mRNA levels of beta(1)-and beta(2) adrenoceptors were recorded, whereas beta(3)-adrenoreceptor mRNA level was significantly elevated in right atria of CMS rats. At the same time, CMS produced a significant increase of beta(1)-and beta(2)-adrenoreceptor mRNA levels in left atria, but did not affect beta(3)-adrenoceptor mRNA level. The results presented here suggest that stress-induced depression expressed differential effects on catecholamine biosynthetic enzymes and beta-adrenoceptors at molecular level in right and left atria of adult rat males. Elevated gene expression of PNMT in left atria of rats exposed to CMS can lead to altered physiological esponse and may play a role in the pathophysiology of cardiovascular function. T2 - Acta Physiologica Hungarica T1 - Regulation of atrial catecholamine enzymes and adrenoceptor gene expression after chronic stress VL - 98 IS - 4 SP - 433 EP - 441 DO - 10.1556/APhysiol.98.2011.4.6 ER -
@article{ author = "Spasojević, Nataša and Gavrilović, Ljubica and Dronjak, Slađana", year = "2011", abstract = "Chronic stress is a risk factor for the development of numerous psychopathological conditions in humans including depression. Changes in gene expression of tyrosine-hydroxylase (TH), dopamine-beta-hydroxylase (DBH) phenylethanolamine N-methyltransferase (PNMT), beta(1)-, beta(2)-and beta(3)-adrenoceptors in right and left rat atria upon chronic unpredictable mild stress (CMS) were investigated. CMS decreased TH and DBH gene expression levels both in right and left atria and increased PNMT mRNA in left atria. No changes in mRNA levels of beta(1)-and beta(2) adrenoceptors were recorded, whereas beta(3)-adrenoreceptor mRNA level was significantly elevated in right atria of CMS rats. At the same time, CMS produced a significant increase of beta(1)-and beta(2)-adrenoreceptor mRNA levels in left atria, but did not affect beta(3)-adrenoceptor mRNA level. The results presented here suggest that stress-induced depression expressed differential effects on catecholamine biosynthetic enzymes and beta-adrenoceptors at molecular level in right and left atria of adult rat males. Elevated gene expression of PNMT in left atria of rats exposed to CMS can lead to altered physiological esponse and may play a role in the pathophysiology of cardiovascular function.", journal = "Acta Physiologica Hungarica", title = "Regulation of atrial catecholamine enzymes and adrenoceptor gene expression after chronic stress", volume = "98", number = "4", pages = "433-441", doi = "10.1556/APhysiol.98.2011.4.6" }
Spasojević, N., Gavrilović, L.,& Dronjak, S.. (2011). Regulation of atrial catecholamine enzymes and adrenoceptor gene expression after chronic stress. in Acta Physiologica Hungarica, 98(4), 433-441. https://doi.org/10.1556/APhysiol.98.2011.4.6
Spasojević N, Gavrilović L, Dronjak S. Regulation of atrial catecholamine enzymes and adrenoceptor gene expression after chronic stress. in Acta Physiologica Hungarica. 2011;98(4):433-441. doi:10.1556/APhysiol.98.2011.4.6 .
Spasojević, Nataša, Gavrilović, Ljubica, Dronjak, Slađana, "Regulation of atrial catecholamine enzymes and adrenoceptor gene expression after chronic stress" in Acta Physiologica Hungarica, 98, no. 4 (2011):433-441, https://doi.org/10.1556/APhysiol.98.2011.4.6 . .